<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06843

Description Mediator of RNA polymerase II transcription subunit 15 (Fragment)
SequenceVLQSLNQRPAQPINMPGMQNKMPGMGMMPSQTGGPMNHMGPIQSMQNNPMLTQMNQMGQGNIPPQMNQMVPGQMGQLGGQMQQNMQSQMQTQLPGQMTNQITGPIGNIQTSISQQMNQIGPGQLGPGQMQQQLNHIQRKPSEMMNTGFPGPRNVTPNQFLRQSPSPSAPSPAGLGAPSSNQMVASPALVPSPSPQHAIMTGPTRSVNSVGMAPSPSSSLNTPGGVGATPSPQQEDQAYRDKVRQLSKYIEPLRRMIAKMSSEGNVDKLSKMKKLLEILSNPSKRMPLDTLLKCEVVLEKLDFKRGDGSVGPPVTTLKEHQIFSPLLEAVSAHLQSPVINHTLQRTFGPCLDALFGPEIKNLPLPLKKQKIEESSSEIPDVLQGEIARLDQRFKVSLDPAQQSGSRCIQLICWLDDRHLPCVPPISVTVPADYPSTPPRCVMAPHEYEATTFLCAVQKALNIRIAKLPRRFSLSQLLDTWEMSVRQASAPKEMSITASTVLMGL
Length503
PositionTail
OrganismTrachymyrmex cornetzi
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Trachymyrmex.
Aromaticity0.03
Grand average of hydropathy-0.425
Instability index66.39
Isoelectric point9.38
Molecular weight54780.85
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06843
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     137.74|      22|      22|      53|      74|       1
---------------------------------------------------------------------------
   53-   74 (49.45/23.00)	QM.NQMG...QGNIPPQMNQMVPGQM
   76-   97 (24.46/ 7.21)	....QLGgqmQQNMQSQMQTQLPGQM
  100-  124 (28.95/10.05)	QItGPIG.niQTSISQQMNQIGPGQL
  132-  152 (34.88/13.80)	QL.NHI....QRKPSEMMNTGFPGPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     109.15|      22|      22|     156|     177|       2
---------------------------------------------------------------------------
  156-  171 (25.85/ 7.85)	..........PNQFLRQSPS..PSAPSP
  172-  194 (29.06/ 9.71)	AGLGAP...sSNQMV.ASPAlvPS.PSP
  197-  222 (30.85/10.75)	AIMTGPtrsvNSVGMAPSPS..SSLNTP
  223-  236 (23.39/ 6.42)	GGVGAT....P........S..PQQEDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.01|      17|      22|     322|     342|       3
---------------------------------------------------------------------------
  322-  342 (25.96/24.35)	FSPLLEAvsahLQSPVI.NHTL
  346-  363 (30.05/17.39)	FGPCLDA....LFGPEIkNLPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.33|      20|      24|     247|     270|       4
---------------------------------------------------------------------------
  247-  270 (28.01/27.62)	KYIEPLRRMIAKMSsegnVDKLSK
  273-  292 (32.32/20.17)	KLLEILSNPSKRMP....LDTLLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.40|      16|      20|       9|      28|       5
---------------------------------------------------------------------------
    9-   28 (26.15/23.49)	PAQ...PINMPG....MQNKmPgmgMM
   29-   51 (25.24/ 9.83)	PSQtggPMNHMGpiqsMQNN.P...ML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.36|      10|      30|     398|     407|       7
---------------------------------------------------------------------------
  398-  407 (19.62/10.38)	PAQQSGS..RCI
  429-  440 (15.74/ 6.96)	PADYPSTppRCV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.30|      17|      77|     381|     397|       8
---------------------------------------------------------------------------
  381-  397 (30.05/21.22)	LQGEIARLDQRFKVS..LD
  459-  477 (25.25/16.76)	LNIRIAKLPRRFSLSqlLD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06843 with Med15 domain of Kingdom Metazoa
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