<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06837

Description Mediator of RNA polymerase II transcription subunit 15 (Fragment)
SequenceDEAVQVSGMPTTKNSIEMENHVFQKAKSKEEYLGFVARLILHVREMNSKKGATDNAPGTAGTNNQGMPDPIGALQTLARQGTGNNQMMSIGGPGPNHQGMIPQSPANTATNLLQSLNQRPAQPMNMPGMQNKMPGMGMMPSQTGGPMNHMGPIQTIQNNPMLTQMNQMGQGNIPPQINQMVPGQMGQLGAGQMQQNMQSQMQTQLPGQMNNQITGPISNIQTSIPQQMNQIGSGQLGPGQIQQQLNHIQRKPGEIMNTGFPGPRNVTPNQFLRQSPSPSAPSPAGLGAPSSNQMVASPALVPSPSPQHAILTGPTRSVNSVGMAPSPSSSLNTPGGVGATPSPQQEDQAYRDKVRQLSKYIEPLRRMIAKMSSEGNVDKLSKMKKLLEILSNPSKRMPLDTLLKCEVVLEKLDFKRGDGSVGPPLKEHQIFSPLLEAVSAHLQSPVINHTLQRTFGPCLDALFGPEIKNLPPPLKKQKIEESPSEIPDVLQGEIARLDQRFKVSLDPAQQSGSRCIQLICWLDDRHLPCVPPISVTVPADYPSTPPRCVMAPHEYEATTFLCAVQKALNVRIAKLPRRFSLSQLLDTWEMSVRQASAPKEMSITASTVLMGL
Length612
PositionTail
OrganismCyphomyrmex costatus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Cyphomyrmex.
Aromaticity0.03
Grand average of hydropathy-0.474
Instability index60.41
Isoelectric point9.29
Molecular weight66213.47
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06837
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     340.14|      50|      50|     167|     216|       1
---------------------------------------------------------------------------
   64-  116 (47.53/13.12)	NQGM........PDP.IGAL..........QTLAR...Q..GT.GNNQmmsIGGP.....gPN.HQGMIPqspantatnllQSL
  117-  155 (50.24/14.25)	NQR.........PAQpM...........NMPG.MQNKMPgmGM.MPSQ...TGGP....mnHM.G....P...........IQT
  178-  228 (88.29/30.19)	NQMV........PGQ.MGQLGAGQMQ.QNMQSQMQTQLP..GQ.MNNQ...ITGP....isNI..QTSIP...........QQM
  229-  268 (56.25/16.77)	NQI..........GS..GQLGPGQIQ.QQL.NHIQRK.P..GEiMN.......TG......FP.GPRNVT...........P..
  269-  329 (53.32/15.54)	NQFLrqspspsaPSP.AG.LGAPSSN.QMVASPALVPSP..SP.QHAI...LTGP.trsvnSV.GMA..P..........sPSS
  330-  380 (44.50/11.85)	SLNT........PGG.VGATPSPQQEdQAYRDKVR.QLS.......KY...IE.PlrrmiaKMsSEGNV............DKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.92|      22|      47|     412|     455|       2
---------------------------------------------------------------------------
  412-  433 (42.36/53.93)	LD..FKRGDGSVGPPLKEHQIF.SP
  459-  483 (32.56/ 6.75)	LDalFGPEIKNLPPPLKKQKIEeSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06837 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) VREMNSKKGATDNAPGTAGTNNQGMPDPIGALQTLARQGTGNNQMMSIGGPGPNHQGMIPQSPANTATNLLQSLNQRPAQPMNMPGMQNKMPGMGMMPSQTGGPMNHMGPIQTIQNNPMLTQMNQMGQGNIPPQINQMVPGQMGQLGAGQMQQNMQSQMQTQLPGQMNNQITGPISNIQTSIPQQMNQIGSGQLGPGQIQQQLNHIQRKPGEIMNTGFPGPRNVTPNQFLRQSPSPSAPSPAGLGAPSSNQMVASPALVPSPSPQHAILTGPTRSVNSVGMAPSPSSSLNTPGGVGATPSPQQEDQAYRDKVRQ
43
356










Molecular Recognition Features






MoRF SequenceStartStop




NANANA