<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06819

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceKSAAEAYRMLVEVYGDTAPTDKSCKEWFRRFKMIQKQGNWVPYELKPRDIVGPKESCLLKLLKSGDSITGDRYRLQLIRLSRALQGKRLEYEQRHDKVILLHDNARPHVAKVIKKYLETLKWNVLLHPHIMAFLDKQSLLFVDTADMLARMARDTLVHARLPNFHIPAAVEVLTTGTYGRLPACIRERIVPPDPITPTEKRSTLQRLNQVIQHRLVTGNLLPQMRNLKIEAGRVTFLIEQEFSVSLTVMGDGPTVPWRLLELEILVSDRETGDGKALVHPLQTRYVHQVVQSRLAESTNPLSEVYHILHYFCQSLQLEVLYSQTLRLIRDRLDDHIHVDEYTPGKCLSISYWRELTRKDPRSELGYRLTVQVDQHDPARPLAVVHIPSLGSKESEIAHRAIRSDQLSMECLLVHTIYVRTRNRLSELKQELQTMLKDVECTLAGSPAILSVPILQPCLRAELLLVTVDTHTGMLQCHVPQYDAPLVPELTMALNGDHSRLPTLISELRFWITQRRCEKTLQHLPATSHERLPVLHHPDHPMSKISRHRMFVQLHRHPTVILIVAFKEKESSPCEIECSFYLAVVKHSSIEDDPHDDSIETEIPKMYLKVQSLIEFDTFVITHGPFTSVDSGNNDQDGGCITEVVETSNNKRRSTGVGGRTDAAGTPQNRRPKHPAYFIPELAHVVALCDERIPFVTLAQELTRREIAHQGLQVEANATALVLKLVQLPAPSPSIATSSAWHALLKRLLSVSIRVQGKGMAKTWTVEFVFYGSPLSSSHPKEQGLRRPVYFQYEMGTADTVSRTVDVLLNDWGQIVHLYLIVHDLAEYFKMEKYNLRNMVSIKSYSYSKLVLAYGPNQGATVTIQWSTNDKAFKLVFGPTNTVTNAHSIMKEQLEAHLNRYTNLAQIIHILNETLQPLTSISKLPSIPQLCVHARPRVPVQTFTIMPQCVTLVRIAYQGMYCLELRLRGGGLVSLRDGAYSRFDRSNVVDEFTPTQGLKAFLSKYVDENAVYRRRSQSEDDNPPSPVTMDSDGAGGNVSFLGHHRSGPQSPAQQREGLRFHPPLTPPSGSNPHTPASPHTANISQANQHQSFGSSPATSFNLASPPSLPPNTPNMLPHPSPGSGLVANSPLNPMHVPSPAGLMPTSSPGPCSNVQVGHSPAGSFMQTGHIDGSPFPASQSMASPAASNWPGSPSVPRPSPARPGQSPSHAALHSPQASDHKTGSHISRVLPQRSWAGAVPTLLTHEALEMLCCPSSHPSALPGPDMSPLERFLGCVYMRRQLQRFIQTEDCLTGINAEPGVVHFKSESLQCRVGLNPTHFQSLHIKVLSLPEYKDQWSVEELQIIEKFFDTRVAAPPYKHNTLSGFGRMLNVRFKVLKDFVQIMKLDLVPSLVQQQQLKWSVQLCLRIPPSAGPIVPPGTEGVHVCRSKILFFLQITRLGISYQGETPSLVLPFVHDVNTNITQLADRRDLTPPPSAIAAASMQLKRFAEYGANQSECSLFPAVRDLLANFTLPSEPPVISQVVPSPAGTQVASAQQIQNTAMQMHSPMAAGQGPQGPGPYGIQGMQPMGMMGGPPQ
Length1576
PositionTail
OrganismAtta colombica
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Atta.
Aromaticity0.06
Grand average of hydropathy-0.272
Instability index56.48
Isoelectric point8.77
Molecular weight175429.40
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06819
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     339.79|      75|      76|    1062|    1136|       1
---------------------------------------------------------------------------
 1059- 1098 (69.28/30.47)	FH............................................pP..LTPP..SGSNP.......HTPASP..HTANI..SQANQHQSF.GSSP......ATS
 1099- 1186 (115.65/56.85)	FNLASPPSLPPNTPNMLPHPSP.GSGL.....VANSPLNPMHVP..sPagLMPT..SSPGPcsnvqvgHSPAGSfmQTGHIdgSPFPASQSM..ASP......AAS
 1187- 1248 (70.69/31.27)	.NWPGSPSV........PRPSP.A..............RPGQSPshaA..LHSP..QASD........HKTGS...H...I..SRVLPQRSWaGAVPtlltheALE
 1510- 1575 (84.17/38.94)	FTL...PSEPPVISQVVP..SPaGTQVasaqqIQNTAMQ.MHSP..........maAGQGP.......QGP.GP..Y..GI..QGMQPMGMM.GGPP.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.34|      25|      76|     423|     447|       2
---------------------------------------------------------------------------
  423-  447 (38.98/25.12)	RLSELKQEL....QTMLKDVEC..TLAGSPA
  470-  498 (33.06/19.99)	HTGMLQCHVpqydAPLVPELTM..ALNGDHS
  499-  525 (37.29/23.65)	RLPTLISEL....RFWITQRRCekTLQHLPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.29|      14|      20|     851|     870|       3
---------------------------------------------------------------------------
  851-  866 (23.05/31.03)	LAYGPNQgaTVTIQWS
  874-  887 (26.23/12.13)	LVFGPTN..TVTNAHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     198.17|      58|     459|     897|     974|       5
---------------------------------------------------------------------------
  673-  711 (57.89/22.90)	...................HP.AYFIPELAHVVALC...DERIP...FVTLAQELTRREIAHQGL
  897-  959 (93.64/81.89)	LN.RYTNLAQIIHILNETLQP.LTSISKLPSIPQLCVhaRPRVPvqtFTIMPQCVTLVRIAYQGM
 1369- 1408 (46.64/17.55)	LNvRFKVLKDFVQIMKLDLVPsLVQQQQLKWSVQLCL....RIP.....................
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06819 with Med14 domain of Kingdom Metazoa
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