<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06818

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDLLYTVNRRSSSKFFSNQECLYNGQSLCSLSSRNIVAFTTMTELDDSNGKTRGCHVYVTDLNMPWHAHKVLSNKHNITALEWDLPGDKLVMADTAGNVQLWMFKDHILNDWVLIGSSYFPGEHILGAAWFHNGKKTGLVTEKKDSIHYSEKFNHLLFAPSVRQFGGRAAEGVLVVSTTGMVGAIMITKDLQNPICYSTESLGNTRHRITAVDLCYGKNGHFLVAVSSGSICLPIRCFRVLVRKNDDKCTITSQALPSFFLQDGAPKDNSCTVVTHLKFVVREDADSLVIAANSESGGFVEVWELREKSQPVHKLFQPKTLEPFKTVVWQYQSQYRCQSPVTAIATTKLSIVTTLPPPSYVIIALADSSVHCLNRLDCLKEVAFSSLNTSWRPDEPSNKYFKNSVSIAHMDLSWLGCVLLACDTQGNMYLYKLLPDGTSMSLSYACTLLEYCLVTGLDWLDILLCLRSSTIEALCERLDVSFNRQLQSTQQYHYILFLSIKTSLYRMLVTGQNKAADLSSLLMIHSVATAFKSLLRPSDLISHDKGPAESLAAVITDVITDVDKVLLHLDPKEFTVEPSTLQSLQQLIQWVADLALNLLARLPEQRMQVKTGGYELLKDHKALNTVRELLVIIRIWGLLRPSCLPVFLRSADNLDVLALLFCLLSKLVQPNGDTQQQVDDGLIGTIIHSKKNTTHAQKEILRIHEDIMTTKLAIKHKDSLVLKENRLHEKNYTIQQSNRLKRYEHLSLPWSTLSVFVAYWFILCPLIWAICYKFAYWPSYWSFLFWTVAFLIWIVIMCGLIIFWRRFQVEQSLEINAISKYGSDKERRPLSVHQISEGEEFLGTKKWNDFHESESKINRENLKRDLPLLVIHKQISGENIEDTDGMVCVEENEKTRSSIASDYTQKSPLQDYLKLVTVSPSEDEVKSPKTPMSPRDLFFIDLIREAERVERSLKTRTLHFFPSETAKSAKTMKSITNGTEHRKDIKDMKDENVKDKKDNKLRSKHECCLLPNQIMIPQLHQGNSITAIVSPILFYQNLPLQLEYGVEPEQLVFTPEMNPVEGCMHSGQIVDTIRHLYLGRQPLLVKQCTRCGGKAQVQNMTRTAAIRAWDQRWTRACRCGGIWRIHKASQ
Length1130
PositionTail
OrganismAtta colombica
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Atta.
Aromaticity0.08
Grand average of hydropathy-0.167
Instability index47.33
Isoelectric point8.36
Molecular weight128467.81
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06818
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.13|      23|      27|     756|     780|       1
---------------------------------------------------------------------------
  756-  780 (41.82/29.18)	FVaYWFIlCPLIWAI..CYKFAYWPSY
  783-  807 (41.32/20.98)	FL.FWTV.AFLIWIVimCGLIIFWRRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.84|      24|      27|     398|     422|       2
---------------------------------------------------------------------------
  398-  422 (42.31/28.61)	NKY.FKNSVSIAHMDLSWlGCVLLA.C
  427-  452 (37.53/20.73)	NMYlYKLLPDGTSMSLSY.ACTLLEyC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.09|      10|      15|     964|     973|       3
---------------------------------------------------------------------------
  964-  973 (16.61/12.56)	ETAKSAKTMK
  980-  989 (18.48/14.89)	EHRKDIKDMK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     242.33|      77|     196|      24|     107|       5
---------------------------------------------------------------------------
   24-  107 (129.50/118.64)	NGQSLCSLSSRNIV....AFTTMTELDDSNgktrgChvYVTDLNMPWHAHKVLSNKHN....ITALEWDL..PGDKLVMA...DTAGNVQLWMFKDH
  219-  308 (112.83/84.65)	NGHFLVAVSSGSIClpirCFRVLVRKNDDK.....C..TITSQALPSFFLQDGAPKDNsctvVTHLKFVVreDADSLVIAansESGGFVEVWELREK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.93|      13|      15|     811|     824|       6
---------------------------------------------------------------------------
  811-  824 (16.48/14.39)	QSLEINAISKyGSD
  828-  840 (22.46/13.47)	RPLSVHQISE.GEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.18|      12|     196|     457|     468|       9
---------------------------------------------------------------------------
  457-  468 (23.77/15.80)	LDWLDILLCLRS
  654-  665 (21.41/13.42)	LDVLALLFCLLS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06818 with Med16 domain of Kingdom Metazoa
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