<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06810

Description Uncharacterized protein
SequenceMTSRPPLGVPSRQPQRALVSTSAQHPSHQQRSLPPPYLSTSTPPARKDSQPNADVTRDAVDLVQGRRVSTPRHGASKLRLELSSELDLGSAPSVTQSPRPLTPSRGEPMAEPTDSDNASSAPSDDSDDVDSPVPMPKRRVQASHQPRSVPRVSSASAPAQAKREVRPKPYTVEVPTNAPRFPATGKADDGSDVDPFCKGLFSGQADFFPWSGNHHEDLWAPEAIQKGTWDRGYANESASARLALIPALKQKSSMNALSSIFMGILSQRRFGGQITAPSTFKPPPRVTLTDTKREMWLKDLANPTISLRRLSRTIPHGIRGRTLLDQCLNKNVPTERAVWLAKCVGANEIRAFKRKGAGGAFIMGGESKWVRDWTMFVEQFLEAVVSSFSETNWKSRVTYAIRLATTLYSAHLLDRDHYLDWILSGLENSVNSRIPMWILIAQITWADLVRTRKHSRRLAFAFLGHLRTVGRPCEKQTLAKPEHADVEVKIENDVDGDILVQLSVQLSALLRRLLKHNPESFIAPTKWLQYRDALKASFSAADAPSQRAFLAINRRNMRLLVATTTSPPAGRQYLVKLLDSTVLGQHDDTLAAKCWSTMDDKWEIVKTLVEWATSLYRPGVTKAYVAARLIKSWTRLDTSVNATPVLLDVVGSVLPGQRLQSKVIFHLVAELVRQGLFSVPHYVQWLIGRGGLHDAADVDPDDAPCASRLLVELPLHCLPENQLVQRSNLLRRAGQYSTVDESQDIRNALGCVDDTLGLSPYLGGTDAQPKRFPLRKLLRRVLSSSKAVQTAIGAHLRDVLTPDLVAKLDSASALSVFGSVRTLTEATEDFSMLSHILDVFTGTAHVDVLAACADTVSFHLDIFLALDCADNLFDALLRQLRSAHREHGSVPRPLLVALSCLSHRMPRREELTKQLERELAQSDRSNAIDACSPLSDNMTMQTQSTDGEVSEQIDKLLASGNTIDHPTMNRLFRHIVPKLELGWTKADENRKVFARLLARLRIFDSQHFDRLMADWISHIRTVKTRPKLSELYPLLVSLGCLSMSIMIRTANAGPATVGDAPLDPGASPTGAEVYLQETLHLIVVPLAKSTYLDDGETYRYQIQQKSSLSEPQSKALVHLIRNALVEYAALRRRAPAYTFLLDEVSLQDQLLETLQYLVIADSTAVAHALNVGALPSNAMVLVHKIITKLLAPGDDGTQEISFDQILGLANELTMPFCQLKLNLDLSAPLPTAPGQVSQEEKGSRFESFTKAMDNAIEARSIMWTSLLPCLGHDIARNLSSQAHLRFLALIPSLKSNTFEQDATSEHRAHLSKNLLGVIETIISGRPAPRSAQLTASLVGKLSDLWAIVSCRDEQWQQARQKVVEHWLPAFLRFITLHSVSAPMPSPNLSQVASRLPMPSKHEARARIILILCGILLELDSHPQTARGPLSQEVFDMAIYLVDSLPDDIRIQCARTILHKPGGSSSTSTTSDPRIHYLFSVPRTAPMENLRLVHREKATSAFCAMARGMGAMFGIGPVVQERITPFTLRRWEILSEPTPNIGENDTSLSLGLFATIKMR
Length1558
PositionKinase
OrganismDrechmeria coniospora
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Drechmeria.
Aromaticity0.06
Grand average of hydropathy-0.209
Instability index46.91
Isoelectric point8.96
Molecular weight172260.32
Publications
PubMed=26975455

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP06810
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     390.31|     126|     137|     769|     902|       1
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  769-  902 (191.43/146.29)	PKRFPLRKLLRRVLSSSKAvQTAIGA..HLRDVLTPDlVAKLD...SASALSVFGSVRTLTEATEDfSMLSHILDVFT.GTAHVDVLAACADTVSFHLDIFlaldcADNLFDALLRQLRSAHREHGSVPR.....PLLVALSCLS
  906- 1042 (198.89/127.87)	PRREELTKQLERELAQSDR.SNAIDAcsPLSDNMTMQ.TQSTDgevSEQIDKLLASGNTIDHPTMN.RLFRHIVPKLElGWTKADENRKVFARLLARLRIF.....DSQHFDRLMADWISHIRTVKTRPKlselyPLLVSLGCLS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     273.50|      75|     135|      13|      96|       2
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   13-   96 (120.57/83.41)	QPQRALVSTSAQHPSHQQRSL.PPPY...LSTSTP..PARKD...SQPNADVTRDAVDL...VQGRRVSTPRHGasklrlelSSELDLGsAPSVTQ
   98-  143 (34.58/10.94)	.................PRPL.TPSR...GEPMAE..PTDSDnasSAPSDD..SDDVDSpvpMPKRRVQAS.........................
  145-  225 (118.35/65.71)	QPRSVPRVSSASAPAQAKREVrPKPYtveVPTNAPrfPATGK...ADDGSDVDPFCKGL...FSGQADFFPWSG........NHHEDLW.APEAIQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     468.92|     135|     219|     373|     512|       3
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  373-  512 (217.01/144.36)	WTMFVEQFLEAVVSSF.SETNWKSRVtYAIRLATTLYSAHLLDRDHYLDWILSG...LENSVNSRIPMWILIAQITW...ADLVRTRKH.................SRRlAFAFLGHLRTVGR.PCEKQTLAKPEHADVEVKIendVDGDILVQLS.........VQLSALLRR
  514-  592 (71.04/37.35)	........LKHNPESFiAPTKW...................................................................lqyrdalkasfsaadapSQR...AFLAINRRNMR.LLVATTTSPPAGRQYLVKL...LDSTVLGQHD.........DTLAA....
  595-  732 (180.87/106.99)	WSTMDDKW..EIVKTL.VE..WATSL.YRPGVTKAYVAARLIKSWTRLDTSVNAtpvLLDVVGSVLPGQRLQSKVIFhlvAELVRQGLF.................S...VPHYVQWL..IGRgGLHDAADVDPDDAPCASRL........LVELPlhclpenqlVQRSNLLRR
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.08|      22|     192|    1216|    1239|       4
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 1216- 1239 (33.90/26.39)	FCQLKLNLDlSAPlPTAPGQVSQE
 1411- 1432 (42.18/23.74)	LCGILLELD.SHP.QTARGPLSQE
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     187.09|      59|     363|    1073|    1136|       7
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 1073- 1136 (89.91/71.79)	VYLQETL.HLIVVPLAKSTYLDDGETyryqiQQKSSLSEPQSKALVHLIRNALVEYAALRRRAPA
 1438- 1497 (97.18/64.83)	IYLVDSLpDDIRIQCARTILHKPGGS.....SSTSTTSDPRIHYLFSVPRTAPMENLRLVHREKA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.07|      15|    1020|     235|     249|       8
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  235-  249 (26.12/14.93)	NESASAR...LALIPALK
 1277- 1294 (21.95/11.27)	NLSSQAHlrfLALIPSLK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06810 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MTSRPPLGVPSRQPQRALVSTSAQHPSHQQRSLPPPYLSTSTPPARKDSQPNADVTRDAVDLVQGRRVSTPRHGASKLRLELSSELDLGSAPSVTQSPRPLTPSRGEPMAEPTDSDNASSAPSDDSDDVDSPVPMPKRRVQASHQPRSVPRVSSASAPAQAKREVRPKPYTVEVPTNAPRFPATGKADDGSDVDPF
1
196










Molecular Recognition Features






MoRF SequenceStartStop




1) AKREVR
2) KLRLEL
161
77
166
82