<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06805

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMASNDGPPLSLRPFPVADNKSKSIGEFVARVNAQPGGFRALTADKLREEIKISEENGVAGPDGDAMSDDDDQDGVDNDDDDEAAKDPLLARLEVLKNLDVAGNTAMLTLDTLSLLLSKQNPTHAGLTLSQQLRDMVGIGTLGADKLGEPTVNEARTKEQAEVAIGWTLMEIDKARNAAREATAFLDREVAAESKYWEDVLAVKQAGWSVCKVPKERNTLGVRFGFSEAAPEFKSNSLAPMRRGDDGAVELDLDRLGGVSEGLVVTYEKNGKVVGRSVPRRRRDDTSLEHRILEARNTIFTQELWHELTRESRALMAYDVRFEGRRLLFDVDKSTRITFELLSLDSCPADDSTLPESDTAEAISSSLHILLSYAHRYNELMRTRPLPPHVSRSRGQQTYTLLRPIIARAMYMLNVRACTRHAANLVKAIRKTGLPASFALHTTQACTADAGPGGPNQPSATQTLIRHMLQPLEFTIRLTILADTSLTIRGRTFLLPFTGSYYHVHLPADSPLKGSDAPLADGYSTLAALADYTHAAVARSLGRHAFARLVRSFPKVEWSRDMIGTSIRDGDADDPLVHLSVESRDAYPAIVLAGVVRAQGRRDLRTWTWTSSEQEASESQTLEESVDEIASRATS
Length634
PositionHead
OrganismDrechmeria coniospora
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Drechmeria.
Aromaticity0.06
Grand average of hydropathy-0.375
Instability index43.57
Isoelectric point5.53
Molecular weight69597.47
Publications
PubMed=26975455

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06805
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     223.65|      74|      97|     307|     382|       1
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  307-  382 (121.54/75.07)	LTRE..SRALMAYDVRFEGRR...LLFDVDKS.TRITFELLSLDSCPADDStlPESDTAEAISSSL..HIL..LSYAHRYNELMRT
  400-  483 (102.11/57.70)	LLRPiiARAMYMLNVRACTRHaanLVKAIRKTgLPASFALHTTQACTADAG..PGGPNQPSATQTLirHMLqpLEFTIRLTILADT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.80|      28|      38|     165|     201|       2
---------------------------------------------------------------------------
  165-  194 (42.83/42.77)	GWTLMEIDKARNAAREATAFldREVAAESK
  206-  233 (51.97/27.21)	GWSVCKVPKERNTLGVRFGF..SEAAPEFK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     186.86|      59|     501|       8|      69|       3
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    8-   69 (92.87/70.15)	PLSLRPFPVADNKS..KSIGEFVARVNAQPGGFRALtADKLREEIKISEENGVAGP...DGDAmsDD
  510-  573 (93.99/60.28)	PLKGSDAPLADGYStlAALADYTHAAVARSLGRHAF.ARLVRSFPKVEWSRDMIGTsirDGDA..DD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.70|      11|      36|     239|     249|       4
---------------------------------------------------------------------------
  239-  249 (21.74/10.66)	PMRRGDDGAVE
  278-  288 (20.97/10.05)	PRRRRDDTSLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.55|      18|      36|      85|     102|       5
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   85-  102 (28.97/17.13)	KDPLLARLEVLKNL.DVAG
  119-  137 (27.57/15.98)	QNPTHAGLTLSQQLrDMVG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06805 with Med17 domain of Kingdom Fungi
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