<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06801

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDAAEYDTNTLLVVSLTDLAGPRMTLSRRADCANVYDPCLQSNIASVVFRIYESPSDLGQNFVPAALEIESSLRTSGHVVFYDPARRGIWHFQIVGKEGHDHITSERLDSSLDLCGYKLVLAEEGTLEPASLPRARTQPQQQAATSTPTSSISSASALDQSQRNTQTSPQSALGSNSQEEAKADDQVGADSKLASILTTYENFITALLLSISSTFCSFSGATPLNYRTVLLPPRPLGRPLGPDDDQDAGSEQVPVLATLGAYLTTTGALVVSFGLSQCTGLGLFTGSSTPLLGTSILAAPFGVVAKNQSPATGEAGTASLAQTPNTQALSHHGRTDLHDSLWKQACLKMLKLRGVATNTLSDCSWVNLVVSKPKLQGGQVDSKRARSVGSMLTIPWPKPLCFRKKAVEVCATSRVGETLLSGHEECHDPLANAKLWFSSAAERDEKMSKRVAERAATSKEASPTDTRAPKASASSPAAVRRPSTAAASAIYPTPPDGIQPPNGATPSFDGAVSSPGNPLSAALTTETDTLPSNTMATADEFDVAIDFDDSKRQRSDNNLLGVSDTVFGDMAGDMFGDNDITEADFNFFDEQPGELDHEAPMIRTGSDSRTREDAPRPGEPPLKPAGDAAPEPHDAVFAKPELKHARSSHIDGATQRGRDGAPGPRGATGGTKRQASPFDPHTVFKRVCASLEASVRGSDRSVPNTSRMRIFERMSFDPTLPMINRKYEQGGQFDYKKISSTEKPKLEPGTLPETDYLKRHGRQGRRWRDARLQPSSLMKCVTTIEPPTGQPSQAKDGSQSDDDDTSAGSVRDDSSCTTEEPTSPLKSSVKMATVEDDAVSQVPARDSDQLEEPDQQLAMELPRLTRPQKPEMPLSVLFSDPEPVRMDLPLADEDMIQVAQILTDQAAIGSLEICNAHNDMDSDSPTATDLGYEAISAGMRNAMGMFQDMVPSLLRGADAVSLKDFLDILDAPLVGQPGRLQPRQIPGRDPNAEPLRATNLYQIPGPHLEVCRADSKLSVLPTAVTFWESLGLGPSSGGKDVTSVCVFPGWSGMADNVETFLDRLKSVYETLKLGSLQKMPLSTDMEDGVIPYEVDKISTSPDATVTGHGSSLVDSMEILRGAINNLTVTDTNLVVYFVYSPGSPWTIVEVCAAFQRFFDSYRKSLASQKTVAANELVLQLVSADVLSSSRSKLVVTPPTELVKLCMQTYDRCTSFGGSMPAPAIRLEPSLPRALDFKLTVSPSVSLMRENSCIHVAYALSVDERWVTAAWTDDRGNQQETASYCLGRRGRPKSRSLNRVAREIWESTLDLISVCKIHWRIVITKCGPMDQQEIEVWLELARKETSASIGMMLMTVDTKPSLQLIPPAVKLPPPPSPFLTTPVSTPLPTPQPNTASPEQSGTPTTPTRDGSGAVGTPGADGQDLDGDAVLSDATEQTWGAVVGHRLNNSVSVLDLHPALVSGYLIKQTGTRIEDAPAVMEVNLVHTDASPRAYEPHFREMLHSFRALGTLARARGTVDSETDVRPWHVAAAEKGVRAMYLLM
Length1541
PositionKinase
OrganismDrechmeria coniospora
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Drechmeria.
Aromaticity0.05
Grand average of hydropathy-0.352
Instability index47.25
Isoelectric point5.15
Molecular weight165963.73
Publications
PubMed=26975455

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06801
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.64|      12|      16|     984|     997|       1
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  984-  997 (19.87/14.61)	QIPGrdPNAEPLRA
 1002- 1013 (25.76/12.46)	QIPG..PHLEVCRA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.95|      17|      18|     140|     156|       2
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  140-  156 (28.61/14.85)	QQQAATST.PTSSISSAS
  160-  177 (25.34/12.24)	QSQRNTQTsPQSALGSNS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1085.15|     336|     381|     222|     600|       3
---------------------------------------------------------------------------
  222-  528 (364.67/268.86)	.....................................................................................................TPLNYRTVL.LPPRPL.GRP..LGPDDDqdAG..............................SEQVP...VLATLGAYLTTTGALVVSFGLSQCTGLGLFTGSSTPLLGTSILAAPFG..VVAKN........QS.PATGEAG.TASLAQTPNTqaLShhGRTDLHDSLWKQACLKMLKLRGVATNTLSDCSwVNLVVSKPKLQGG.........QVDSKRARSVGSMLTIPWPKPlcfrkkAVEVCATSRVGETLLSGheechdplanaklwfssaaeRDEKMSKRVAERAATSKEaSPT..DTRAPKASAS.....SPAAVRRPSTAAASAiyPTPPdgIQPPNGATPSFDGAVSS.PGNPlSAALtTETD
  529-  854 (472.36/261.72)	TLPSNTMATADEFDVAIDFDDSKRQR.....SDNNLLGVSDtVFGDMAGdmFGDNDITEADFNFFDEQPGELDHEAP.....................mirTGSDSRTRE.DAPRPG.EPP..LKPAGD..AA..............................PE..PhdaVFAK..PELKHARSSHID.GATQ.RGRDGAPGPRGATGGTKRQASPFDphTVFK.........RV.CASLEASvRGSDRSVPNT......SRMRIFERMSFDPTLPM....................INRKYEQGG.........QFDYKKISSTEKPKLEPGTLP........ETDYLKRHGRQGRRW....................RDARLQPSSLMKCVTTIE.PPTgqPSQAKDGSQSddddtSAGSVRDDSSCTTEE..PTSP..LKSSVKMATVEDDAVSQvPARD.SDQL.EEPD
  860- 1152 (248.13/122.80)	ELPRLTRPQKPEMPLSVLFSDPEPVRmdlplADEDMIQVAQ.ILTDQAA..IGSLEICNAHNDMDSDSPTATDLGYEaisagmrnamgmfqdmvpsllrgaDAVSLKDFLdILDAPLvGQPgrLQPR......qipgrdpnaeplratnlyqipgphlevcraDSKLS...VLPTAVTFWESLG.LGPSSGGKDVTSVCVFPGWS....G............MADNvetfldrlKSvYETLKLG...SLQKMP....LS....TDMEDGVIP...YEVDKISTSPDATVTGHG.SSLVDSMEILRGAinnltvtdtNLVVYFVYSPGS....PWT........IVEVCA.............................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.21|      15|      20|    1415|    1429|       4
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 1415- 1429 (27.54/18.96)	TPGA.DGQDLDGD.AVL
 1436- 1452 (19.68/10.91)	TWGAvVGHRLNNSvSVL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06801 with Med13 domain of Kingdom Fungi
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