<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06784

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMGAPPPSMADGGVMDGMDSMDELFGEAADGLGVAGVPLPQAPLPAKLTLRLAQMQRIGCCTRIAWSNTGSIACISDNGRMISFRTLVRDQQAAQYKLSEACKRGIEAPPGKEFVHLSFSGLGLDMAVVDRGGGVQVYSLGGAINRPHPAAGDFGGLAGNSDIDAVVGMHWLRVFPTEFSAPYFSPARKSGDIWSVSTKSPDQKAPRINHPSPRGNALLYITCSGRFTLLYQNEPGIWFHVSAELESSASSEELLSHAAFGEHQDHLYAVTYGAAKRFRVYRVSISWNPSQITRNAHNFIIVNPVLNISHLTALEHAAPQHAGNARLTLLRIVSPPPPHAENGVHVSSVLAVFTHASPPMDPASNQACYSTLCRWTIESMIPTLHPGFSKLKQSGPTPVQNPVTVLKRQNDIFSAKVVVSVDVQYHNTLLALLASDGTIEYRDTATWSVIEPLADMTTASSLPQAGFEHNAVDHLTDLAPSPDGAYIVYAKPDGSLTATGMTLRYGWQLLDDNLGDTRPFIETAIVCLARQYAILSTHTTSNDEILALLPPDLPQEMRLLFVKQIMRMLCRALDVALLDHTRQQKAALMEASLSRAMSAQLALGTKPNTRDRTFQGQFAYAYLNLRYIGLALLQSLTQRDTSSRAGEIGPSLAGPVKWSLNFIIYIVDSLAEMKRAAAAVKAPTSSSVFEHWTAQTGNPVLFLLLCSTTRVILRMHIYYIVNAYIRNFIQAPPPPTRSLPDRHAVDEVQRLAKSMPLVLSAYMEFILEVDNAVRSALADVSASRRLEIEMALMTDGTVPQELTSVVAGSLAEIAVPKLLDSGTAADGGRLYFWDTRWLGVEKAGGEGERQRRYDAIRKVPLLLGTKEEGGRRECRRCGAEMEEIAQERMRSLLPWLHHAQRLCYCQNYWWVK
Length911
PositionTail
OrganismAcidomyces richmondensis BFW
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Teratosphaeriaceae> Acidomyces> unclassified Acidomyces.
Aromaticity0.08
Grand average of hydropathy-0.095
Instability index45.36
Isoelectric point6.96
Molecular weight99859.17
Publications
PubMed=26973616

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06784
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.86|      20|      20|     320|     339|       1
---------------------------------------------------------------------------
  320-  339 (34.38/18.64)	HAGNARLTLLRIVSPPPPHA
  343-  362 (33.11/17.69)	VHVSSVLAVFTHASPPMDPA
  365-  381 (26.37/12.64)	QACYSTLCRWTIESMIP...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.78|      32|      41|     814|     850|       2
---------------------------------------------------------------------------
  814-  850 (50.73/44.27)	VPKLLdsGTAADGGRlyfWDTRWLGVEKAGGEGERQR
  858-  889 (60.05/36.45)	VPLLL..GTKEEGGR...RECRRCGAEMEEIAQERMR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.45|      24|      26|     762|     787|       3
---------------------------------------------------------------------------
  764-  787 (37.26/26.85)	FILEVDNAVRSALADVSASRRLEI
  789-  812 (39.19/21.28)	MALMTDGTVPQELTSVVAGSLAEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.47|      11|      26|     600|     610|       4
---------------------------------------------------------------------------
  600-  610 (19.47/11.74)	LALGTKPNTRD
  629-  639 (18.00/10.30)	LALLQSLTQRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.01|      25|     278|     199|     230|       7
---------------------------------------------------------------------------
  199-  230 (31.32/39.89)	SPDqkAPRINHPSPRGnALlyiTCSGrFTLLY
  480-  504 (47.69/28.38)	SPD..GAYIVYAKPDG.SL...TATG.MTLRY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.00|      18|      39|     537|     556|       9
---------------------------------------------------------------------------
  537-  556 (27.91/22.38)	HTTSNDEilALLPPDLPQEM
  579-  596 (30.09/17.66)	HTRQQKA..ALMEASLSRAM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.81|      25|     207|     237|     266|      10
---------------------------------------------------------------------------
  237-  266 (33.77/36.60)	WFHVS..AELeSSASSeelLSHAAFgEHQ..DHL
  446-  474 (39.04/23.18)	WSVIEplADM.TTASS...LPQAGF.EHNavDHL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06784 with Med16 domain of Kingdom Fungi
Unable to open file!