<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06781

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMQCSVYETIDKSKERNDTLQAIITRLRNEGVLCTSVKDQLWIFRNDGNASAVLPCGEDMELKVMERIRLDAEREVETEDGREIDDVLLESIEASVSFQLAKISNVIRFGPSVWILPNLEKPDGGAEGVLLRLNLRYSEDGSLYAITTTEPTHFTVMHDFGLETENDIILAPNGVIARRLLPEDSEARGASAGDAWQSRVIKSLATEGIELPEGTKWIPVRLNTTFGRAEFVTWPINLCFSSSRFTPNGSRHIVNREAWRSWFAPSNDPTGFKSSLTFAEGWYLGSESRQNAAIQELSRIPDGTNGITDLEMTEVDPMATSPSFVQRTTDQQAAMSGIYPTPEDNLFVHQAQQQLMSDVGTNSAQDSTHLISELISGNDENNLRGHTSTADPPALHTHSDDLFGDISGEMDFGGGEVGDADFDFFNEEEVASIPDDEDIAMIEPEEVASGDEDLVPGHDASKAKQFDDDENMGPPTSESQDLTDLQPLEIPFTFDQGPSNQMADDTPMQVLDETVKQPPQKPLSPFGIKERLLPPPVPASAKSGINESTDRAKRRISAFDPVKFKDGLDIGGKYSAAFGPSVNDWHSQVTQLPEADINLPPRSKKPRMRHPSDQDSEVPNDESESEEDSYESASSISDDNMPPKLPWENRKRKRSELDANMASGEFQIIWQQATVEERSLSLNEEETEALLEQLLSLDAAEDPAHTAQMTLIHEDPHEDDATATVAIEKLPSVGDLEDLKKLDLVYIAQLISAQAVSCLGNIIESLKLTCERHSTVGPTIFALQSFVEQLCGHLLPETISCDISRLALNREPNGRTQPSLAPARHGQPRPPQRTETSSAGPDITIVPPPFVRVQRGNDIYEMLPPALEFWETLSLAPSNGTKHIRAFCVCPFNYDLLRLVNGFMSELGAAYESCKLGVFAHSRNVNENNELDDYEDGLAPVELAVDSDRSIEAALQAYDAACADLGTFLSSIGHLENERDRTFVIFLVNPFAYEPRAGQHLCASFWKLYKAYCDNIPKASRNHPRSDIVLQMLPIELIASADTLVCLSAGQLGTLAKEIYDRCPPSSAREPDVNSALPNYAAPFVELAIPPPKRIGFQLTAEPSGDLLYEASPLHVAYATSEDGQWVTIAWTDSSGRYQSNVSLCMRGKSFAELAEDIWQRTRDIMAARDVSWRVFLITAQDFDIAISHCWRKIIERPRKHPYSVTLLSADLQPDLKLTLPAAAEGGNAVSTGGFLTPAGTPQASGSTASPETSSHNIPPTPAPSEPPITFTPEHEPDAHLVDLTDDTLVVLFSQSYSSVATSGEIIPLANGALIKRDDVGIGAAPVGLHLPCLALSLLWTVQVRPNGVVDEGNVKQGEMTLKDVLRMYRNLTVLTRAKGLHLDERNCAVMPVHLVSALKGAKSLNGYLS
Length1409
PositionKinase
OrganismAcidomyces richmondensis BFW
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Teratosphaeriaceae> Acidomyces> unclassified Acidomyces.
Aromaticity0.07
Grand average of hydropathy-0.360
Instability index48.74
Isoelectric point4.61
Molecular weight154661.20
Publications
PubMed=26973616

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP06781
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     690.17|     239|     259|     342|     600|       1
---------------------------------------------------------------------------
  246-  339 (40.41/10.93)	........................PNG.SRHIVNREAWRSWFAPSN.DPTGFKSSLTFAeGWYlgSESRQNAAiqelsriPDGTNGITDLEMTEVD...P...........................................maTSPSFVQRTtdQQAAMSGIYP....................................................................................................................................................................................
  342-  515 (204.42/150.77)	.................................................................................................................................................EDNLFVHQA..QQQLMSDVGTNSAQDSTHLISELISGN.DENN.LRGHTSTAD...PPALHTHS........DDLFGdiSGEMD..FGGGEVgdadfdffnEEEVASIPDDEDIAMIEPEEVASGDEDlvPGHDASKAKQFDD...DENMGPPTSES....QDLTDLQPLEIPFtFDQGPSNQmaddtPMQVLD...ETVK
  516-  766 (335.03/194.30)	QPPQKPLSPFgIKE...RLLPPPVPAS.AKSGINESTDRAKRRISAFDPVKFKDGLDIG.GKY..SAAFGPSV.......NDWHSQVTQLPEADINL.PP...........................................rsKKPRMRHPS..DQD..SEV.PNDESES............EEDS.YESASSISDdnmPPKLPWENrkrkrselDANMA..SGEFQiiWQQATV.........EERSLSLNEEETEALLEQLLSLDAAED..PAHTAQMTLIHEDpheDDATATVAIEKlpsvGDLEDLKKLDLVY.IAQLISAQ.....AVSCLGniiESLK
  776-  947 (110.31/52.62)	GPTIFALQSF.VEQlcgHLLPETISCDiSRLALNREPN..GRTQPSLAPARHGQPRPPQ.RTE..TSSAGP......................DITIvPPpfvrvqrgndiyemlppalefwetlslapsngtkhirafcvcpfnYDLL...RL..VNGFMSELG..AAYESCKLGVFAHSRNvNENNeLDDYEDGLA...PVELAVDS........D................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.18|      17|      98|    1045|    1061|       2
---------------------------------------------------------------------------
 1045- 1061 (29.32/21.88)	CLSAGQLGTLAKEIYDR
 1144- 1160 (31.86/24.52)	CMRGKSFAELAEDIWQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.32|      44|    1171|     171|     221|       3
---------------------------------------------------------------------------
  171-  221 (67.60/74.92)	PNGVIarrllPEDSEARG.ASAGDAWqsRVIKSLA....TEGIELPE.GTKWIPVRL
 1345- 1394 (64.71/51.06)	PNGVV.....DEGNVKQGeMTLKDVL..RMYRNLTvltrAKGLHLDErNCAVMPVHL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06781 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AIQELSRIPDGTNGITDLEMTEVDPMATSPSFVQRTTDQQAAMSGIYPTPEDNLFVHQAQQQLMSDVGTNSAQDSTHLISELISGNDENNLRGHTSTADPPALHTHSDDLFGDISGEMDFGGGEVGDADFDFFNEEEVASIPDDEDIAMIEPEEVASGDEDLVPGHDASKAKQFDDDENMGPPTSESQDLTDLQPLEIPFTFDQGPSNQMADDTPMQVLDETVKQPPQKPLSPFGIKERLLPPPVPASAKSGINESTDRAKRRISAFDPV
2) GPSVNDWHSQVTQLPEADINLPPRSKKPRMRHPSDQDSEVPNDESESEEDSYESASSISDDNMPPKLPWENRKRKRSELD
3) PNGRTQPSLAPARHGQPRPPQRTETSSAGP
4) STGGFLTPAGTPQASGSTASPETSSHNIPPTPAPSEPPITFTPEHEPD
292
578
811
1230
561
657
840
1277










Molecular Recognition Features






MoRF SequenceStartStop




1) FGIKERLL
525
532