<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06779

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAQPAQNTLKGAQAMVDLQQLLGDVFDNVLSDFVQLSSQPAPGPADPEQRKQRLLAHLHGTRQQLLRALVLLNWKPWKVLAELVDHERVADIAAAHVRTMHEVVGQMRQQAVQRIMAGSYLNMFDVNTALEVLTTGTYQELPSIILHRPPLFQPPPASLARQKARLAHVTHLIRTRLVQVALPPGLKVVSVSNGTAVLRAEGLYEAKLTLVPSEALPGADEDAAGGSGPAAAAAPDADGPSWAAAAAAAAGTDPVAAAAAAQRWKWRLIHFVLCIGVPFYDPRQPGQILNTCNFHMVLAADNAAYLARQRRCAGAAAGPGAGAGAPSESAATPAPSGLTGTGGAAGAGPGGGGSLAAAVKRSEDDEVGAPLAVMHAILTDVAGRLLADELAAAARALAAPGSRWHGHIAVKPSSLLSPGVRIEYWVSAPPLLAQRALPTSGTSGEDFRAVKPGPPYLELGMSEGGCVEVLHSPSSLHKPVAVSKLRLDTFRVNVEEVLMRAANMSSQFQLLQIRAELKAHLLEAMGNRAGTLRLNNLARQLWCREGQALQQPGAEEQEEEQARQQPQPGDGGAAGPSGPEAMDVDGGAAAQKPVQPQQAPIPPPTTPVPEVSGLIARAAPPEEAAGALVLLNAPVLEYLVAGTTELKIGKHLFSGRLTLRPGQDERDEGSLDHAATIAAHEDHINAAAMAAYNAASAGGDAYPAWRALREACTALSHVLQRTHTSTDATHFIQAARRASLHVCRLPRGLLESFTAACPSLAIEPRPREKSATWALQSVPFPPNFPPLEAVPPETPPLRVPHCLAFFLQSRLSLNSPHVLVAVSCNKQLMPIKVLSCIPVPPSTYRLPEQLVAACMAVSSSGHNHSHAAGGALGGAAAGGGTAAQGRSSPRAFANGHDAGGRSPDASPIREASGAGAGRLSAAGTGVSGLASSDAVAGPGGSGSGCGAAPSGIPSLPSGTSPQQQANGRPSSFGGGGALPQQPAQAQSLAHPHHGHSRPTGQQVAVMLAQQQLSSVVRWCRRRMVWEVLLVQLQAVGAAFEELCFVGPAPPPTHGSHNGPSRAAGQGASAPGPGRLKVTCIAGTQLPCQLARRRGLTPARVGPTCLELELGPDALAGQVTARLYGRFLCATACAPVGTAGAGAAAGFVLEPSRGGGPSGDVCLRRQYCLERGDSALTLVQDVAAIIRMQTLLARLEMTVPAAGGLAGASRGAGGPLRRPQLKPQLEVLAQASMPAQAGGHAAQQLQGNQAGMGPEEQAAPGSHPPLVKPEAAAPGLPNGRPSWAEADANGYVVLPSAKRIKVEPGEPDGTGPSAYGNGAAGSGGAAGYTWQRHGGMANGAVGNGHGGATSCLHAPGSTAAPTPSQTAGPSAGDGGGGGGGGAAAAGGLTWHWPLVGTLSSGEPFGRLFSDVVLCTVTCGSGHALPPEYLHVLEDFAEAGEEGKLLDAAAVAAWPLAGFCASLAPPLLARYGLSPELDVRPVLHQPPFCHRIVCRRRAPGGGSSSGPIMIDLWCQAVGRSYLKVSSPSPLHPAQQAQALGAGAEAAGPDGGATAGAAGAACQPTLVLQGVQRLAPERLGGRVHVAVGGRGAVHTGLGQRPVAAPGPGAPLWLLVPNDCVRQAVEVVYSALQNATNV
Length1634
PositionTail
OrganismGonium pectorale (Green alga)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Chlorophyta> core chlorophytes> Chlorophyceae> CS clade> Chlamydomonadales> Volvocaceae> Gonium.
Aromaticity0.04
Grand average of hydropathy-0.063
Instability index51.23
Isoelectric point8.23
Molecular weight166822.47
Publications
PubMed=27102219

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06779
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|    1342.84|     180|     180|    1202|    1381|       1
---------------------------------------------------------------------------
  182-  328 (138.24/29.58)	...........................................LPPGL.....KVVSVS..NG...TAvlR...AEGlyEAKLTLV...PSEA..........L.PG.ADEDAAGG...S..G.P........AAA.A...APD.A....DG.....PS.......WAAAAAAA.................................................AGTDP........VAAAAAAQR..............W....KWrlihfvlcigvpfydpRQ.PGQILN..TCNFH....MVL.A...ADN..A.................AYLARQrrCAGAAAG....PGAGAGAPSE
  342-  479 (125.65/26.13)	GGAAG.....AGPGGGGSLAA...................AvKRSEDD.....EVGAPL..AV...MH..A...ILT..DVAGRLL...ADEL..........A.AA.ARALAAPG...SrwH.GHIaVK...PSSlL...SPGV..........RiEY.......WVSA.........................................................PPLL..AQRALPTSGTSG..............E....DF................RAvKPGPPYLELGMSEGGCVEVL.H...SPSSLH.................KP...........................
  519-  735 (151.61/33.25)	AHLLE.....AMGNRAGTLRL...................N.NLARQLwcregQALQQP..GA...EE..Q...EEE..QARQQPQpgdGGAA..........GpSG.PEAMDVDGgaaA..Q.KP..VQ...PQQ.ApipPPTTPvpevSGliaR.AA.......PPE.EAAGALVLLNAPvleylvagttelkigkhlfsgR...LT.LRPGQDerdegslDHAATIAA..HEDHINAAAMAA..............Y....NA................AS.AGGDAYPAWRALREACTALS.H...VLQRTH.................TSTDAT..HFIQAA...............
  736-  900 (167.16/37.51)	...........RRASLHVCRL...................P...RGLL.....ESFTAAcpSLaiePR..P...REK..SATWALQ...SVPF..........P.PNfPPLEAVPP...E..T.PPL.RV...PHC.L...AFFL.....QS...R.LS.......LNSPHV..LVAVSCNK.....................QlmpIK.VLSCIP.........VPPSTYrlPEQLVAACMAVS..............S....SG................HN.HSHAAGGALGGAAAG............GGTA.................AQGRS.....SPRAF....ANGHDAGG..
  901- 1004 (138.86/29.75)	...................RS...................P.DASPIR.....E...................................ASGA..........G.AG.RLSAAGTG...V....SGL.AS...SDA.V...A.G.P....GG...S.GS.......GCGAAPSGIPSLPS............................................GTSPQQQ..ANGRPSSFG............................................GG...GALPQQPAQAQSL......................................AHPHHG....HSRPTGQQVA
 1010- 1159 (146.99/31.98)	QQLSS.....VVRWCRRRMVW...................E.VLLVQL......................Q...AVG..AAFEEL.......C..........F.VG.PAPPPTHG...S..H...........................NG............................................................PSRA.......AGQGASAP..GPGRLKVTCIAG..............TqlpcQL................AR.RRGLTPARVG......PTCL.ElelGPDALAgqvtarlygrflcatacAPVGTA..GAGAAAGfvlePSRGGGPSGD
 1202- 1381 (323.24/80.31)	GGLAG.....ASRGAGGPLRR...................P.QLKPQL.....EVLAQA..SM...PA..Q...AGG..HAAQQLQ...GNQA..........G.MG.PEEQAAPG...S..H.PPL.VK...PEA.A...APGLP....NG...R.PS.......WAEADANGYVVLPSAK.....................R...IK.VEPGEP.......DGTGPSAY..GNGAAGSGGAAG..............Y....TW................QR.HGGMANGAVGNGHGGATSCL.H...APGSTA.................APTPSQ..TAGPSAG....DGGGGGGGGA
 1385- 1604 (151.08/33.10)	GGLTWhwplvGTLSSGEPFGRlfsdvvlctvtcgsghalpP.EYLHVL.....EDFAEA..GE...EG..KlldAAA..VAAWPLA...GFCAslappllaryG.LS.PELDVRPV...L..HqPPF.CHrivCRR.R...APG......GG...S.SSgpimidlWCQAVGRSYLKVSSPS.....................P...LHpAQQAQA.......LGAGAEAA..GPDGGATAGAAGaacqptlvlqgvqrL....AP................ER.LGGRVHVAVG.GRGAVHTGLgQ...RP..VA.................APGP.........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     185.58|      60|     109|       1|      62|       2
---------------------------------------------------------------------------
    1-   62 (101.25/59.75)	MAQPA.QNTLKGAQ.AMVD....LQQLLGDVFDNVLSdfVQLSSQP..APGPADPEQRKQRL..LAHLHGTR
  107-  176 (84.32/43.69)	MRQQAvQRIMAGSYlNMFDvntaLEVLTTGTYQELPS..IILHRPPlfQPPPASLARQKARLahVTHLIRTR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06779 with Med14 domain of Kingdom Viridiplantae
Unable to open file!