<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06772

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLMMDDSINVDDLFGEPTSLELGLPPSASSARGLAQRLDEMRLLGCCQKIAWSKLGCIAYISQDSLRVKVRHLQCRPSDGKWVLSDETPLMPITEAHGGHALTHLSWNEAGSDLAVVDVTGRVSVYHIPFALNSVNGLRQPAFSPDDGSQIVGMMWLNTQRSVHAFYQAAKVQGRWAYSPFRRRPIGPFHPANKAALLCITRSGSMKLLYQNPDGRWDDISVDLKSTSYSDRMLSHAALVATQNGILVATYSICQKIRFYRVQINWNPPQWDPAQQPKQTPPQFPVPSFRFTHSKVETSCTVPGMPRNDGEEPDMMQQSVSNPLYSLSRLDIFLPASDNAAGTTANPWIVAVFSTPPQATPDHPGPQGPASVIVRWQLDTATFTLHPKFDEMATKRNSTQMKPRPVLRRLEDIYSDRYVISVDQIEYGNVVAITYDDSSVSFYDPKTMALFNGVDDANTVTGLAQAGFHYAPDASGQGQHVSFSPSACAAVMLDNDGQTHLKVMEHSYGAENGLYDENAQITFINEVYRALPINCNFTVEQEKLMNHPYIPKCLSVQAALGFADKYKPRSFASSVSWSILQLRHAAILYPFFFQYNKGIQAEPHDPVKTTNSLALIILLSSMSRAFLRFICRGLRGIHAGYTNASLAGDSRLQYAEICQALDATPARIDVYEKFLSAVDSAVRHAYHGAGFGDTERPGPEKELLVNARIPPVLVAAVSTILRQTVPGLKSDVDRMAIYMHDYSWLGFGSDRRSELYRRTREVDIIKKTPIRMTIAQGSNGPQLGKQNSQGVLRRRCVRCCDVSEGTYPPRSVLAFRMIFKLGHLRSCICGGMWTLESGLNEVGK
Length845
PositionTail
OrganismAspergillus luchuensis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.09
Grand average of hydropathy-0.253
Instability index45.11
Isoelectric point8.32
Molecular weight93807.84
Publications
PubMed=27651094

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06772
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     410.70|     111|     199|     293|     407|       1
---------------------------------------------------------------------------
  212-  291 (63.40/28.83)	...................QNP.DGRWDD..ISVDLKSTSYSDRMLShaalvATQNgilVATYSIC...........QKIrfyrVQINWNPPQWD...PAQQPKQTPPQFPVpsfR...................................
  293-  407 (193.95/114.93)	THSKVETSCTVPGMPRNDGEEP.DMMQQS..VSNPLYSLSRLDIFLP.....ASDN...AAGTTAN...........PWI....VAVFSTPPQAT...PDHPGPQGPASVIV...RW...QLDTATFtLHPKFDEMatkRNSTQMKPR.PV
  480-  608 (153.35/82.01)	QHVSFSPSACAAVMLDNDGQTHlKVMEHSygAENGLYDENAQITFIN.....EVYR...ALPINCNftveqeklmnhPYI....PKCLSV..QAAlgfADKYKPRSFASS.V...SWsilQLRHAAI.LYPFFFQY...NKGIQAEPHdPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.81|      36|      91|      75|     113|       2
---------------------------------------------------------------------------
   75-  113 (63.66/55.19)	QCRPSDGKWVLSdetPL..MPITEAHGGHALTHLSWNEAGS
  169-  206 (62.16/44.84)	QAAKVQGRWAYS...PFrrRPIGPFHPANKAALLCITRSGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.65|      28|     428|       6|      37|       3
---------------------------------------------------------------------------
    6-   37 (36.59/35.66)	DDSiNVDdlFGEPTSLEL..GLpPSASSARGLAQ
  437-  466 (46.06/26.86)	DDS.SVS..FYDPKTMALfnGV.DDANTVTGLAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.71|      28|      42|     638|     679|       4
---------------------------------------------------------------------------
  638-  669 (34.29/44.45)	IHAGYTNASLaGDSRLQYAEicQALdATPARI
  683-  710 (50.42/22.64)	VRHAYHGAGF.GDTERPGPE..KEL.LVNARI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06772 with Med16 domain of Kingdom Fungi
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