<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06769

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPHSSAGVQPWGRSLRALNNGSGRVDASQALVQSDPQLEKLSMSMPQPLPRQPAVIDLTANTSDSQDREPPAKRLKLEAPPGSCPPEGSPAPGSGEARSTPGTASSKPNPLAWRGRPVWSFQALISETTGAVETKEDDTNSQGKTPASPPPLPLIPWKPAPQEASGSNSAKPADVASAKEVQTTPYRIVVPPVAPKLKGERVADFSPWTGNHPEDTLNDHTAKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFAAALEKRQSHSTIATPSSFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKVLLDQCLGKGIPVPRAIWLARCVGANEIRAFKRKGTSGTLALGLETKWVRDWTSTVQQFLESVIGTCGSSDWKIKMTYAVSLTSRLFFERLLDHDQYLSWFLVSLEAAPLNTVPVWLLMLGIYWNNIMRYRKRGRRLAEVLLEKLRLIKQPGQPTALEPLVDRLSRCIRRLVLEHTSSVILPASWDQYKDLIASCLNLKELPDKTTLQNLAERNVRVQLPTNRQGTSQQLPQQHVIHLFDSIRSAHDVLSTSSACLNAVEDKATLVAKLLEWAATPFRHGSRRVYTSVRLLRKWKMSGMDVESYILAFLADTQITSRVNMDNVYHIIAELVRSQTFSVGRYLQWLMAKGVANDPLPDQTKAISDDVRLLIQLPLARLPEYVRNLRNTLLSRAGITASHEESIVETVKASIAQRLPKIFGPQASDAMLTDQPLSSLTWAVKSEIGLWIRRGVSGHCRDPVRKYAHIPMLADSGVSALTPVEFYNIRDVLESFGDISMLADVLKQATNCDDNIVLASVADTINYHFDSLSVIGAATDLFKGLIESYARLKRLGAPGLDLIFSLIELGLRMPSEFNTVALLRQDLSRIENKSALAAPSPLSDNLSMAFNDADSSFQEKLDQILFSGGGMDESTMDSIFNSLTGALANENGHVKLSANDICRYLAYLRSFHPKRFDARLVRWVCGVLKSPSRFAMVRVLPPLIGVGCVTIHAFVMLVKKLLQSERIASVVPKVTDLQLDLLELLVPQEPSGSRYTDMVTYRYYLAQQEFIDKHPEECLNIIRAAVPLISTRQTENAGEANAADLTKCAMILLQTLLTQKPERMVQCCTQKLVGQDPASTMILQKALDALLGFNPQDPQAMSEAERVIGMNNDFSLPICQLKLQLLFNAEAGNGVDNGIVDVMFKAAMADARSKRSHWYGLVSLMNQDAVRQIRERAEKGFFSVPILEEPIGDPTVADKSNSIETARLYLAIIEKLAYSIPETGVPSVAPMLVEKMELLLQKFITMQPNPSTPAESCQIAQARSNFERSLAFWFSALLRLVVIHRSAFNTAALTPKPIGLQEQARMLVSIFCITLARLPDRVIRLYPSANYFPHPVQSESYRPCPGILLQTHALDVAAALIDTFPDEARQQCARFLKEKCPPFLQFQNDSRFLYLLGPVMDAPTLNSSQPASLPSPAAGGSTPTPTGNLAGGPPNSQSLSSASGLPAGLSEGVNCIASHLRLQYRGRVLGAYPVRPWELLEDAAPIVGMNDTAVSLKYFDARRVRA
Length1583
PositionKinase
OrganismAspergillus luchuensis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.167
Instability index48.75
Isoelectric point8.95
Molecular weight174604.76
Publications
PubMed=27651094

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP06769
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     589.24|     238|     317|     229|     496|       1
---------------------------------------------------------------------------
  229-  329 (75.53/66.91)	..................................................................................................................................................................................................................................DRTQVSQNESNTARPSLYAQLkhRSGLQMLSSVfAAALEKRQSHSTI........ATPssFKPPPRVTLTDNK.REAW.LRDLANPSVPLRRLSRTiphGIRGKVLLDQCL
  330-  646 (333.04/295.59)	GKGIPVPRAI.WL.ARCVgANEIRAFKRKGTSGTLALGLETKWVR..DWTSTVQQFLESVIGTCGSSDWKIKMTYAVSLTSRL..FFERLLDHDQYLSWFLVSLEAAPLNTVPVWLlmlgiywnnimR......YRKRGRRLAEVlleklRLIKQPGqPTALEPlVDRLSrcIRRlVLEhtssvilpaswdqykdliasclnlkelpdkttlqnlaernvrvqlptNRQGTSQQLPQQHVIHLFDSI..RSAHDVLSTS.SACLNAVEDKATLvakllewaATP..FRHGSRRVYTSVRlLRKWkMSGMDVESYILAFLADT...QITSRVNMDNVY
  655-  811 (180.67/121.48)	SQTFSVGRYLqWLmAKGV.ANDPLPDQTKAISDDVRLLIQLPLARlpEYVRNLRNTLLSRAGITASHEESIVETVKASIAQRLpkIFGPQASDAMLTDQPLSSLTWAVKSEIGLWI...........RrgvsghCRDPVRKYAHI.....PMLADSG.VSALTP.VEFYN..IRD.VLE..............................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     214.94|     102|     309|     876|     984|       2
---------------------------------------------------------------------------
  876-  920 (39.67/23.56)	.........................................................................................................................................................................................................................................................................GLDLIFSL..IELGLRMPseFNTVA..LLRQDLSRIENKSALA.APSPLS
  921-  984 (68.89/51.90)	DNLSMAFNDADSSFQEKLDQILFSGGGMDESTMDSIFNSLTGALanENGHVKLSandICRYLAY...........................................................................................................................................................................................................................................................
 1186- 1233 (31.49/12.37)	................................................................lrsfhpkrfdarlvrwvcgvlkspsrfamvrvlppligvgcvtihafvmlvkkllqseriasvvpkvtdlqldllellvpqepsgsrytdmvtyryylaqqefidkhpeeclniiraavplistrqtenageanaadltkcamillqtlltqkpermvqcctqklvgqdpastmilqkaldallgfnpqdpqamseaerviGMNNDFSLpiCQLKLQLL..FNAEAgnGVDNGIVDVMFKAAMAdARSKRS
 1237- 1295 (74.89/43.05)	GLVSLMNQDAVRQIRERAEKGFFSVPILEEPIGDPTVADKSNSI..ETARLYLA...IIEKLAY...........................................................................................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     173.67|      31|      34|      81|     111|       3
---------------------------------------------------------------------------
   47-   74 (40.89/20.22)	PQ...P..LPRQPAVIDLTANTSDSQDREPPAK
   81-  111 (58.10/32.37)	PPGSCP..PEGSPAPGSGEARSTPGTASSKPNP
  118-  147 (42.22/21.16)	PVWSFQ..ALISETTGAVETK.EDDTNSQGKTP
  149-  173 (32.46/14.27)	SPPPLPliP.WKPAP..QEA...SGSNSAKP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.41|      10|     869|     517|     526|       5
---------------------------------------------------------------------------
  517-  526 (19.14/11.40)	CLNLKELPDK
 1389- 1398 (19.27/11.53)	CITLARLPDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.48|      23|     252|    1048|    1070|       8
---------------------------------------------------------------------------
 1048- 1070 (38.72/22.54)	VPKVTDLQLDLLELLVPQ....EPSGS
 1302- 1328 (34.77/19.45)	VPSVAPMLVEKMELLLQKfitmQPNPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06769 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GERVADFSPWTGNHPEDTLNDHTAKQGHYDRTQVSQNESNTARPSLYAQL
2) MIPHSSAGVQPWGRSLRALNNGSGRVDASQALVQSDPQLEKLSMSMPQPLPRQPAVIDLTANTSDSQDREPPAKRLKLEAPPGSCPPEGSPAPGSGEARSTPGTASSKPNPLAWRGRPVWS
3) NSSQPASLPSPAAGGSTPTPTGNLAGGPPNSQSLSSAS
4) QALISETTGAVETKEDDTNSQGKTPASPPPLPLIPWKPAPQEASGSNSAKPADVASAKEVQTTPYRIVVPPVAPK
200
1
1483
123
249
121
1520
197










Molecular Recognition Features






MoRF SequenceStartStop




1) AKRLKL
73
78