<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06760

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTSSEQWGTFLQQCLLHRIDAAEFKNLTRLLMQRYPIGEAQLLDVLLETRLATGIKWDPLPPLYIDCLCKMGLVRTSTMLNSLLKHSSIHDKLPSAGGSEATAAAAAAVQGKQKRKCYTLMTDIRVVQDAMLSVSTGTASKTFAEALSIFASIVDWIQAVVAWHNSHLDTSHQTGGLMSSPDAVSLFESLGILLAALSGTAKGLEVLSADSHEALKIKLGQALSAYLPLCVEVSLPLRNRLDSLQKEFNLFGEPSSKALDVSMMENVNVNALQFEDSVMDGPVINSRAGLYVYINAMGHYQVLIEELITASFDVLSNANYRNESSRTMFLFRSFLVNKLPTFIAAMLAASIVSLPLPMELCISHALSRLDPNTFPSFSQMFAMQSNTVLSDVRQEFLFACASHKLIPESSIERLLGENPMQTLPVGGPYNKDELVSQINANPERAEQLINEIESMEGNAGAIVGAITDVMHHLCNQKETMTLKNICNSLSRRPQALDVILLFRSLKQVLQPLCALLDAWHWDEDQGESQPVYDEFGSILLLVLTFKFRYDLRPQDMGIGGSNSFVLRLLENGFCSQKLDDLSEKQNKNLGSWINALFMAEGISEETMSACSPQEFYMLVTTLFNQSLSACEAGKLDFDTLKGGFEYLLEPFLLPSLILALNWLGNHIWESESDPSIPLKALHSLISPSSISGEAKEIHRTVLNITARSLEEQLKSIRARQPDDTIKPILEALEPHLSFQRSGSTRRSELESWTAHTPGGLLASIRSTFQSLILWSTSPDMSMAPQSYTHRQFIAGIHIQGSMRVLCALIDELKLQATTSPTNTTGSSDLALDIAATMICAPLADSFAVDQNTYSPHHHIDPTNTTKEIPPRNPILTPRGALYQLHDSVPKICEKDPLRAEIIVRLWRRVNAALTPPSQLDMNNIIQNMQLGVGVGGPGQMDLDTSGAGGHEEESTINQMLDNAVAAGMDGGGGAGGMGGMGSGGLDTSIDDVLNAADMAVGNPEFLDLDMEGLF
Length1014
PositionTail
OrganismAspergillus luchuensis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.06
Grand average of hydropathy-0.025
Instability index47.96
Isoelectric point5.01
Molecular weight110858.54
Publications
PubMed=27651094

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06760
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.17|      13|      64|     934|     946|       1
---------------------------------------------------------------------------
  934-  946 (28.32/13.94)	VGGPGQMDLDTSG
 1000- 1012 (23.85/10.70)	VGNPEFLDLDMEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     177.35|      56|     159|      38|      95|       2
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   38-   95 (88.53/71.84)	GEAQLLDVL.LETRLATGIKWDPLPPLYIDcLCKMGLVRTSTMLNSLLKHSSIHDKlPS
  199-  255 (88.81/61.44)	GTAKGLEVLsADSHEALKIKLGQALSAYLP.LCVEVSLPLRNRLDSLQKEFNLFGE.PS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.78|      30|      34|     788|     820|       4
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  788-  820 (44.70/41.95)	THRQF...IAgIHIQGSMrvLCA.LIDELKL.QATTSP
  821-  855 (38.08/24.13)	TNTTGssdLA.LDIAATM..ICApLADSFAVdQNTYSP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     381.98|     119|     300|     353|     494|       5
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  369-  494 (197.09/138.78)	LDPNTFPSFSQMFAMQSNTVLSDVRQEFLFACASHKLIPESSIERLLGENPMQTLPVGGPYNKDELVSQINANPERAEQLI..................NEIESMEGNA.GAIVGAITDVMHHLCnqketmtLKNICNSLSRRPQ
  648-  785 (184.90/95.85)	LEPFLLPSLILALNWLGNHIWESESDPSIPLKALHSLISPSSISGEAKEIHRTVLNITARSLEEQLKSIRARQPDDTIKPIlealephlsfqrsgstrrSELESWTAHTpGGLLASIRSTFQSLI.......LWSTSPDMSMAPQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.30|      14|      32|     948|     963|       6
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  948-  963 (20.79/16.43)	GGHeeESTINQMLDNA
  983-  996 (23.51/12.25)	GGL..DTSIDDVLNAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.33|      20|      35|     860|     881|       7
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  860-  881 (34.30/26.78)	DPTNTtkEIPPR.....NPILTPRGAL
  895-  919 (30.04/16.87)	DPLRA..EIIVRlwrrvNAALTPPSQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.28|      16|     302|     182|     197|       8
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  145-  160 (26.80/16.40)	EALSIFASIVDWIQAV
  182-  197 (24.47/14.35)	DAVSLFESLGILLAAL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06760 with Med5 domain of Kingdom Fungi
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