<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06758

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGSITNIRAIDGFSHIYWRIYTDDPGESPSNGYAILKHLSRLKDLELQLRDRNCLVSSYPRRLCLWVFSATPGFESLSPLSPNDGRDDSGRLAIGSATLKVSSSGNVSAVDLVKNLSTETQNASGSAGSQRPNAMTPFATIYASFISAVSGAVSLQLVRQRNAIPLGSRTLFTVVEKDGCDNSHVSKNDLALAPSLTTLQIQLTSAGKLTVALQTVSQAGLTRLLTPEEVPASIHDTPPGTDLWLSPSGSIARLVAANPPQLNAGSPYPSNVGGSGNEKSSPATRKQWKVNVLWWLSNFGLPVDGIDDEAWVEVEVWEPFYSRLAGEVWRPSEEGASMLPLKRILWPAIYCFRRTKSASSEFYGEMEGVSSIAGDPLDFAEKWRVTEKLSFAEASPKPPSVHQEAPTKDQDASSPDLLNLPEGIESLSRASQYPDLQTASLVYPTPPDGAAATGLNPLVTSDTFTDDIEQNSNFMQQDRLNHHRQLSKERTGTDVISFGPSAGLVVGSGLYDTNDDDDLFGDMNEKDFGTKGITDADFSFFDDPDFDRGGVGEQAEAIQELSGFMDTDEPEIQATVDGQASPEQTPAMNIASAQLSPVVATADMQPEKTPQEAKAPVFTPQEDKPRTISPPLSPVEFGFNLRGIERNKGPDTVTNDIPTVGLPRHSGKMKSSTSKDPDNYGSPYSEEMQESSSDSDMSSSVSADSDESASESGLSPATFSTRKRKRTRSNSGTSLALSQDKSTVRTGQETAAQRPEDSVFLGNFLSTFSDWSMAGYFSLAQNQVSPVLIRKDIQVQVAQLLVDQVTQSSLDHKIDGTLGLLDYADEVCSPETLQGDAAFVRGMERLDLNSFVSLQDSNALSPSSSNGANPRQSSQRRETGKGTIVKIPPPHLRVRRGKDFLETLPPAISFWETFGLEPAHGRKDILAYCIHPHFAARAADTFLERLGLVYSGCNLGEHRRGESSNVFDRGLGSWNISSSADSRYSEVIQSLKTICGVLGKPYPTMLTLLILTETGSAFLSTPPSKDSNIVVYIVNPFTHATSLVDICAAFWSLFQQYIAEADKQQTRQLNELVLQIIPMDFVTSAESLVVPPQAEYLNLALEVYSRCPPKSSEVGPVNCAPPVLLAEPIPRSIGFKLSSEGSSPLQEGKHLHIACSRSLDQRWLSVAWSDNFGALQRNMSYCLRYRNSVAARPLPEVRGEIWKATRDIMDTIQTRWKVIIVSTDPVDQEEVDTWTNFADQYGKARSMTLDLVILGATTPPDLHLEPPYLPIPLSMFNQQPSSTPVATPNLGGGVSSPDQFGTAPTPPGGWGAPANASTPTDTFPEVESESLLTDIYDETWGVVLSHRLNSSLHQTEYRPALASGYLLRRKGSTDGDGLYTMSVNILFARRSPSSYDTLLREILGMYRDLATLARARGTRTVQQGTLPWHVATAIKAQTLLSYAL
Length1448
PositionKinase
OrganismAspergillus luchuensis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.08
Grand average of hydropathy-0.353
Instability index50.50
Isoelectric point4.96
Molecular weight157532.20
Publications
PubMed=27651094

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats
>MDP06758
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.93|      50|      50|     235|     284|       1
---------------------------------------------------------------------------
  201-  253 (74.19/40.03)	TTLQIQLTSAGKLTVALQTVSQAGLTRllTPEEvPASIHDTPPGTDLWLSPSG
  254-  304 (81.74/44.92)	SIARLVAANPPQLNAGSPYPSNVGGSG..NEKSsPATRKQWKVNVLWWLSNFG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     688.17|     247|     427|     714|     993|       2
---------------------------------------------------------------------------
  336-  532 (215.90/107.17)	SEEGASmlplkrilwPAIYCFRRTKSASSE..............FYGEMEGV.....SSIAGDPLDFAEKWRVTEKLSFAEASPKPPSVHQEAPTKDQDASSPDLL..NLPEGIESLSRASQYPDlQTASlvyPTPPDGAAA..TGLNPLvTSDTFTDdiEQNSNFMQQDRLN..HHRQLSKER.TGTDVISFGPSAGLVVGSGlydtnddddlfgdmneKDF..................................................................................................................
  714-  992 (375.83/256.63)	SESGLS.........PATFSTRKRKRTRSNsgtslalsqdkstvRTGQETAAqrpedSVFLGNFLSTFSDWSMAGYFSLAQNQVSPVLIRKDIQVQVAQLLVDQVTqsSLDHKIDGTLGLLDYAD.EVCS...PETLQGDAAfvRGMERL.DLNSFVS..LQDSNALSPSSSNgaNPRQSSQRReTGKGTIVKIPPPHLRVRRG................KDF...............lETLPPAIsFWETFGLEPAHgRkdiLAYCIH..PHFAARAADTFLERL......GLVYSGCNLGEHRRGESS..NVFDRGLGSW.NISSSADSRYSEVI
 1301- 1425 (96.44/40.42)	...........................................................................................................................PD.QFGT..aPTPPGGWGA.................................................................................panastptdtfpevesESLLTDI.YDETWGVVLSH.R...LNSSLHqtEYRPALASGYLLRRKgstdgdGLYTMSVNILFARRSPSSydTLLREILGMYrDLATLARARGTRTV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.26|      15|      24|       4|      20|       3
---------------------------------------------------------------------------
    4-   20 (23.46/19.43)	PGGSITNIRAIdgFSHI
   29-   43 (28.79/16.34)	PGESPSNGYAI..LKHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.60|      11|      24|     578|     590|       4
---------------------------------------------------------------------------
  578-  590 (17.92/17.14)	ATVDGQasPEQTP
  604-  614 (22.68/13.95)	ATADMQ..PEKTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.87|      20|      24|      69|      88|       5
---------------------------------------------------------------------------
   69-   88 (37.36/21.34)	LWVFSATPGFESLSPLSPND
   96-  115 (31.51/16.78)	LAIGSATLKVSSSGNVSAVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.96|      25|     544|     616|     651|       6
---------------------------------------------------------------------------
  620-  645 (43.28/38.65)	PVFTpQEDKPRTISPPL.....SPVEFGFNL
 1126- 1155 (39.68/11.22)	PVLL.AEPIPRSIGFKLssegsSPLQEGKHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.40|      27|     544|     130|     158|       7
---------------------------------------------------------------------------
  130-  158 (34.87/33.84)	SAGSQRpNAMtPFATIYASFISAVSGAVS
  160-  186 (44.53/31.25)	QLVRQR.NAI.PLGSRTLFTVVEKDGCDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.98|      16|      17|     665|     680|       8
---------------------------------------------------------------------------
  647-  660 (22.64/12.73)	GIERNKG..PDTVTND
  665-  680 (28.84/18.46)	GLPRHSGKMKSSTSKD
  685-  697 (17.51/ 7.98)	GSP.YSEEMQESSS..
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06758 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DLQTASLVYPTPPDGAAATGLNPLVTSDTFTDDIEQNSNFMQQDRLNHHRQLSKERTGTD
2) QPSSTPVATPNLGGGVSSPDQFGTAPTPPGGWGAPANASTPTDTFPEVES
3) SFFDDPDFDRGGVGEQAEAIQELSGFMDTDEPEIQATVDGQASPEQTPAMNIASAQLSPVVATADMQPEKTPQEAKAPVFTPQEDKPRTISPPLSPVEFGFNLRGIERNKGPDTVTNDIPTVGLPRHSGKMKSSTSKDPDNYGSPYSEEMQESSSDSDMSSSVSADSDESASESGLSPATFSTRKRKRTRSNSGTSLALSQDKSTVRTGQETAAQ
439
1283
543
498
1332
757










Molecular Recognition Features






MoRF SequenceStartStop




1) HIYWRIYT
19
26