<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06744

Description Mediator of RNA polymerase II transcription subunit 25
SequenceMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEELRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTESLVQKIGERGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQQPADVSQDPRHMVLVRGLVLPVGGSSTSGSLQTKQAVPLPPAPASAATLSAAPPQALPPVPPQYQVPGNLSAAQVAAQNAVEAAKSQKAGLGPRFSPINPLQQAAPGVGPPFSQAPAPPLAPVPPGAPKPPPASQPSLVSTVAPGPVLAAPAQPGAPSLAGTVTPGGVNGPSAAQLGGPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGAQQAPPVLGPILEEQARPPQNLLQLRAPQPQPQGAVGASAATGQPQPQGATQAPTGAPQGPPGAAPGPPPSGPILRPQNPGANPQLRSLLLNPAPPQTGVPPPQASLHHLQPPGAPTLLPPHQSMGQPQLGPQLLHPPPAQSWPTQLPQRAPLPGKGAPGEDRGLEWESLKPLVRTLLPKGLP
Length742
PositionUnknown
OrganismMus musculus (Mouse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Mus> Mus.
Aromaticity0.05
Grand average of hydropathy-0.222
Instability index56.58
Isoelectric point8.98
Molecular weight77864.49
Publications
PubMed=19468303

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06744
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     482.55|      65|      67|     565|     629|       1
---------------------------------------------------------------------------
  193-  270 (61.52/13.01)	.....LLFEKAAPPALLEPLQQ....PADVSQDPrhmvlvrglvlpVGGSSTSGSL..QTKQAVP..LPP.APA..SaatlsaaP.PQALP..PVPP
  271-  320 (50.17/ 9.13)	.........QYQVPGNL...SA....AQVAAQNA............V..EAAKSQK..AGLG......PRFSPI..N.......PlQQAAPgvGPPF
  326-  381 (68.77/15.49)	PPLAPVPPG............A....PKPPPASQ.............PSLVSTVAP..GPVLAAP..AQPGAPSlaG.....tvT.PGGVN..GPSA
  459-  505 (52.13/ 9.80)	TTLGPLFRN.SR....MVQFHF....TNKDLESL............KGLYRIMGN...GFAGCVH..FPHTAP........................
  566-  629 (116.93/31.97)	.VLGPILEEQARPPQNLLQLRA....PQPQPQGA............VGASAATGQP..QPQGATQ..APTGAPQ..G.......P.PGAAP..GPPP
  632-  688 (73.42/17.08)	PILRP....Q.NPGAN.PQLRSlllnPAP.PQ....................TGVP..PPQASLHhlQPPGAPT.lL.......P.PHQSM..GQPQ
  692-  742 (59.60/12.35)	QLLHPP.PAQSWPTQ..LPQRA....PLP.GKGA............PGEDRGLEWEslKPLVRTL..LPKGLP........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.05|      30|     111|      39|      69|       2
---------------------------------------------------------------------------
   39-   69 (53.28/30.00)	YLLPAIEYFN.GGPPAETDFG..GDYgGTQYSLV
  151-  183 (44.77/20.77)	YLLPAVESTTySGCTTESLVQkiGER.GIHFSIV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06744 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GSLQTKQAVPLPPAPASAATLSAAPPQALPPVPPQYQVPGNLSA
2) HKQVQQQKLEQQRGMGAQQAPPVLGPILEEQARPPQNLLQLRAPQPQPQGAVGASAATGQPQPQGATQAPTGAPQGPPGAAPGPPPSGPILRPQNPGANPQLRSLLLNPAPPQTGVPPPQASLHHLQPPGAPTLLPPHQSMGQPQLGPQLLHPPPAQSWPTQLPQRAPLPGKGAPGEDRGLEWESLKPLVRTLLPKGLP
3) VAAQNAVEAAKSQKAGLGPRFSPINPLQQAAPGVGPPFSQAPAPPLAPVPPGAPKPPPASQPSLVSTVAPGPVLAAPAQPGAPSLAGTVTPGGVNGPSAAQLGGPALG
237
544
283
280
742
390










Molecular Recognition Features






MoRF SequenceStartStop




1) GEDRGLEWESLKPLVRTLLPKGL
719
741