<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06741

Description Mediator of RNA polymerase II transcription subunit 25
SequenceMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEELRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTESLVQKIGERGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQQPADVSQDPRHMVLVRGLVLPVGGSSTSGSLQTKQAVPLPPAPASAATLSAAPPQALPPVPPQYQVPGNLSAAQVAAQNAVEAAKSQKAGLGPRFSPINPLQQAAPGVGPPFSQAPAPPLAPVPPGAPKPPPASQPSLVSTVAPGPVLAAPAQPGAPSLAGTVTPGGVNGPSAAQLGGPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGAQQAPPVLGPILEEQARPPQNLLQLRAPQPQPQGAVGASAATGQPQPQGATQAPTGAPQGPPGAAPGPPPSGPILRPQNPGANPQLRSLLLNPAPPQTGVPPPQASLHHLQPPGAPTLLPPHQSMGQPQLGPQLLHPPPAQSWPTQLPQRAPLPVAKRKREGEGRVFREKWERDYFFVEVKSMPTCLICKKNVSVLKEYNLKRHYESQHSKSYDQYTAQSRDTLLQELKRALRASEALESQE
Length801
PositionUnknown
OrganismMus musculus (Mouse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Mus> Mus.
Aromaticity0.06
Grand average of hydropathy-0.301
Instability index58.99
Isoelectric point9.10
Molecular weight85324.77
Publications
PubMed=19468303

Function

Annotated function 
GO - Cellular Component
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06741
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     405.33|      65|      67|     565|     629|       1
---------------------------------------------------------------------------
  193-  270 (69.15/15.34)	.....LLFEKAAPPALLEPLQQ....PADVSQDPrhmvlvrglvlpVGGSSTSGSLQTKQAVP..LPP.APA..SaatlsaaP.PQALP..PVPP
  271-  320 (54.64/10.62)	.........QYQVPGNL...SA....AQVAAQNA............V..EAAKSQKAGLG......PRFSPI..N.......PlQQAAPgvGPPF
  326-  381 (75.80/17.50)	PPLAPVPPG............A....PKPPPASQ.............PSLVSTVAPGPVLAAP..AQPGAPSlaG.....tvT.PGGVN..GPSA
  565-  629 (126.79/34.10)	PVLGPILEEQARPPQNLLQLRA....PQPQPQGA............VGASAATGQPQPQGATQ..APTGAPQ..G.......P.PGAAP..GPPP
  632-  688 (78.94/18.53)	PILRP....Q.NPGAN.PQLRSlllnPAP.PQ....................TGVPPPQASLHhlQPPGAPT.lL.......P.PHQSM..GQPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     178.40|      47|      67|      76|     123|       2
---------------------------------------------------------------------------
   41-   69 (23.60/ 8.12)	......................LPAIEYFNGGPPAETDFGgdyGGTQYSLV
   76-  123 (77.94/50.83)	CAPESYVqCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIA...EGLSTALQ
  146-  192 (76.86/45.72)	CNSPPYL.LPAVESTTYSGCTTESLVQKIGERGIHFSIVS...PRKLPALR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.21|      44|      75|     428|     486|       3
---------------------------------------------------------------------------
  428-  486 (56.60/70.50)	PCQVYVNHGenLKTEQwpQKLIMQLIP..........QQLLTtlgplfrNSRMVQfhftNKDLESLKGL
  505-  558 (71.61/42.81)	PCEVRVLML..LYSSK..KKIFMGLIPydqsgfvngiRQVIT.......NHKQVQ....QQKLEQQRGM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06741 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GSLQTKQAVPLPPAPASAATLSAAPPQALPPVPPQYQVPGNLSA
2) HKQVQQQKLEQQRGMGAQQAPPVLGPILEEQARPPQNLLQLRAPQPQPQGAVGASAATGQPQPQGATQAPTGAPQGPPGAAPGPPPSGPILRPQNPGANPQLRSLLLNPAPPQTGVPPPQASLHHLQPPGAPTLLPPHQSMGQPQLGPQLLHPPPAQSWPTQLPQRAPLPVAKRKREGEG
3) VAAQNAVEAAKSQKAGLGPRFSPINPLQQAAPGVGPPFSQAPAPPLAPVPPGAPKPPPASQPSLVSTVAPGPVLAAPAQPGAPSLAGTVTPGGVNGPSAAQLGGPALG
237
544
283
280
723
390










Molecular Recognition Features






MoRF SequenceStartStop




NANANA