<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06739

Description Mediator of RNA polymerase II transcription subunit 12-like Protein
SequenceMFNSSLLYEKRPLKKPKIGPPDVYPQEPKQKEDELTSVNVKHGFLTMTHLSDEFGTARNCNISASKVGDYFNDIIKRKEELSMLPDSGRKRQQINPKDNFWPATIRTKNAIELWFKDLAGNKPLMHLSKKAPNFNKKEEIFIMLCEYQVPMMRAAWFIKLSSAYTVAVSEAKIKKRQMPDPTTEWTGTMLKFLKEQILKLQDYYSQGEKPPQTPSLTQAATTETEQKLAMRHWIYCTQLLKYMYEEGLMDRQEVLTWILELLEKMRSQPSDDGILRLLMPLCLQYLDEFVQSELLSRRLAHLCCKKLGYMLNNVAENNLITSPQSETKTEQKDNEKEKKDVPVTNPMQSTLMEYQNCPHHRDIVLQLSTVIQTITLECPTALVWCGTGVGSVWHGSPLDLLPMVPSSLPMAARCDMNTYRKQLQFAEHCIRERSKRAEGRWCTEKWQNSSAGTITNRVLAALDALDRHRFDKMDSTNSLDTLYTKVFGGNSDQENSVVKLLCEWAVSPERTGEHRALAVAALLDRRQSDSATNGDQETAPGDDKDSNCSVPGGPPMFQQLLMKFLDSDAPVPAPDDCPQKKTAFSNLVHLFAELIRRDVFSHDAYMCTLISRGDLLGPEETTDVSTSHQSHHTKLEDHSHNMDFDDATIDHDLDKILQNIKEDQQNSMDVPDSPKEHDHGHHPHQSSIGHVPMETDHNDHKVKPSRHLLYTTHFPLYQDDPFSQHDCNQRHVLLYGVGKVRDEARHTVKKMSKEICKLFSKKFSIDVAEGGKVKKHSRNEFNFEATTQKCQSLSYFDQHLVTWQCSVTVIEMLNSFATGNSNYLPVQEHVAFLFDLMELALNIYGLIDVCIQILKELPEVETQLYNKNSVLTRNYTTSLSLYVVGVLRRYHCCLLLSPEQTSAVFEGLCKVVKHVSNPGDCSSAERCILAHLYDLYSSCSLLKSKPHTGEPFGNAYPKIRQALYTALQPTPSSNYVYNSGYMQEVFTNPRRGGRIESSWARPLNESANNRYSFVSNAVIYVCRETDNERLNDLAIMCAEMTACCNSLASEWLGVLLALCCPIAHPGYYTDVLAQLDIQDVSIHNALAVFTCILIARHCFSLEDFVGRVALPSLLKVKTLDNGSGAAEGGMRLTCHLLLRLFRTAEGPQPGLYSVGSPPLTAPRPPLGVRLSCDRHLLAAAHRNIHVGPVLAVLKAVLIVGDATAREGTELSISHILGTSDLMSGGDGPSLDLAQSSTGNAESTASLSAFACHVLREICSQQWVLERCLSHPEELCDSDNLLDPLLSHSQAQRLLHMICYPDAGTSIEELDQKSMISRILENLEQWTLRMSWLDLQLMFRQFTPNSQELSQWLDTVAKAAIDVFQLNSSSSNSPKSDEKKPEIKNRAQNSIWLVAPLVSKLPSAVQGRVLKVAGQVLESGGWCKETKSKGRGGSDSQSLLSHQPFLTLVLTCLKGQEEGQREGLLSSLHQQLSQLVQLARDGNLQDICNNERTLDGLQLRFALVGGVFEAFQRNPSATTDWALLLVQLVTNGLIDLHTHSELFTTVIDMLATLIHSALATDSQDEGRKMYQNLMKKLKKEVGERHNASLQHVRQLLPLPRSVTEIIAVEPIGWVTDGKGNKISFDSLDKKHGFQVTDKQRVSSWDILEGMKNPAPLFWAWFGAVRLERKPLTGEDNHRLLKYHTHNLQRPPSHYLDPPPLPPEDLEPVPDKPLKDCDLKADTPSSVDQSPAAMGKGRGKGQRRPRKPKTVPGQLPVNPMGMNQPQMGQGQMPMQVPGPNPQMHNMGGYGQGPMPQQGQQYGNNQQQWYNQQQQQQGYYPPQMANVNRFERPQINQSKQALSNLLRSRHPLNMGPTAQTPQGPGPQANYGPMRSFPRQPMRQQHPGAIQQNQVKNMFPQQYGSMQAGMNQLYGNYGGTPNTMMPNNMQASQQMMQGSQPNMFAGQQQGFGQPRPPQPDYRGMAQNPRAQYMQQAPNVTMNANMNTMGGMGGQGGPAPPYSRQTPQGMQQGVQQPNQFQQQRMRQQMMAMQQQQQQQGGPQGNTSSLVAHLQRQMNPNPYQHQPPPYNM
Length2066
PositionKinase
OrganismTribolium castaneum (Red flour beetle)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Coleoptera> Polyphaga> Cucujiformia> Tenebrionidae> Tenebrionidae incertae sedis> Tribolium.
Aromaticity0.07
Grand average of hydropathy-0.542
Instability index48.16
Isoelectric point7.08
Molecular weight232105.60
Publications
PubMed=18362917
PubMed=19820115

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06739
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     120.08|      19|      19|    1753|    1771|       1
---------------------------------------------------------------------------
 1753- 1771 (40.95/17.25)	LPVNPMGMNQPQMGQGQMP
 1899- 1917 (24.51/ 7.29)	YGSMQAGMNQLYGNYGGTP
 1920- 1937 (31.71/11.66)	MMPNNMQASQ.QMMQGSQP
 1960- 1973 (22.92/ 6.33)	MAQNP....RAQYMQ.QAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.56|      21|      23|     690|     710|       2
---------------------------------------------------------------------------
  670-  684 (19.73/ 7.73)	.VPDSPK..EHDHGHHP..H....
  690-  710 (41.48/25.25)	HVPMETD..HNDHKVKPSRH.LLY
  713-  735 (28.34/14.66)	HFPLYQDdpFSQHDCN.QRHvLLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     149.27|      20|      23|    1999|    2018|       3
---------------------------------------------------------------------------
 1795- 1810 (22.71/ 7.09)	....QGQQYGNNQQQWYNQQ
 1880- 1898 (32.40/13.43)	QQHPGAIQQN.QVKNMFPQQ
 1999- 2018 (42.18/19.84)	RQTPQGMQQGVQQPNQFQQQ
 2021- 2034 (26.86/ 9.81)	RQQMMAMQQ..QQ....QQQ
 2043- 2060 (25.11/ 8.66)	SLVAHLQRQ..MNPNPYQHQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.02|      20|      23|     276|     295|       4
---------------------------------------------------------------------------
  276-  295 (35.91/20.47)	RLLMPLC...LQY.LDEFVQSELL
  297-  320 (26.10/12.95)	RRLAHLCckkLGYmLNNVAENNLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.80|      20|      23|    1306|    1325|       5
---------------------------------------------------------------------------
 1306- 1325 (34.70/24.98)	IEELDQKSMISRILEN...LEQW
 1329- 1351 (34.10/24.40)	MSWLDLQLMFRQFTPNsqeLSQW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.00|      18|      23|     338|     358|       6
---------------------------------------------------------------------------
  338-  358 (27.83/28.11)	KKDV..PVTNPMQSTLMEyqnCP
  360-  379 (24.17/13.95)	HRDIvlQLSTVIQTITLE...CP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.42|      13|      23|     543|     555|       8
---------------------------------------------------------------------------
  543-  555 (26.15/13.78)	DKDSNCSVPGGPP
  566-  578 (26.26/13.87)	DSDAPVPAPDDCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.60|      22|      51|    1031|    1053|       9
---------------------------------------------------------------------------
 1031- 1053 (38.63/31.40)	NDLAIM.CAEMTACCNSLaSEWLG
 1084- 1106 (35.97/23.84)	NALAVFtCILIARHCFSL.EDFVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     124.96|      22|      22|    1648|    1669|      10
---------------------------------------------------------------------------
 1648- 1669 (42.68/22.33)	GMKNPAPLFWAWFGAVR.LERKP
 1672- 1690 (33.10/15.44)	GEDNHRLL...KYHTHN.LQRPP
 1695- 1711 (27.10/11.13)	...DPPPLPPEDLEPV...PDKP
 1861- 1877 (22.08/ 7.52)	......PGPQANYGPMRsFPRQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.91|       9|      22|     233|     243|      11
---------------------------------------------------------------------------
  233-  243 (13.64/18.66)	WIycTQLLKYM
  257-  265 (17.27/10.79)	WI..LELLEKM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.05|      17|      17|    1256|    1272|      13
---------------------------------------------------------------------------
 1256- 1272 (33.61/24.03)	EICSQQWVLERCLSHPE
 1273- 1289 (30.43/20.86)	ELCDSDNLLDPLLSHSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.69|      17|      17|    1611|    1627|      14
---------------------------------------------------------------------------
 1611- 1627 (30.69/24.23)	GWVTDGKGNKISFDSLD
 1631- 1647 (30.00/23.47)	GFQVTDKQRVSSWDILE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.32|      15|      17|    1823|    1838|      15
---------------------------------------------------------------------------
 1823- 1838 (21.96/19.16)	NVNRFERPqINQSKQA
 1841- 1855 (27.36/18.33)	NLLRSRHP.LNMGPTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.91|      16|      42|    1938|    1953|      16
---------------------------------------------------------------------------
 1779- 1793 (23.04/ 8.41)	PQM.HNMGGYGqGPMP.
 1938- 1953 (32.43/15.20)	NMFAGQQQGFG.QPRPP
 1982- 1996 (33.44/15.93)	NTMGG.MGGQG.GPAPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.59|      24|     115|    1111|    1137|      17
---------------------------------------------------------------------------
 1111- 1137 (38.83/33.12)	PSLlkvKTLDNGSGAAEGGMRLT...CHLL
 1228- 1254 (36.76/22.97)	PSL...DLAQSSTGNAESTASLSafaCHVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.52|      26|      55|     446|     471|      18
---------------------------------------------------------------------------
  446-  471 (46.06/33.80)	WQNSSAGTITNRVLAALDALDRHRFD
  504-  529 (45.47/33.26)	WAVSPERTGEHRALAVAALLDRRQSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.15|      11|     730|     244|     256|      19
---------------------------------------------------------------------------
  244-  256 (16.27/16.23)	YEEGLMdrQEVLT
  977-  987 (22.88/14.21)	YNSGYM..QEVFT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.76|      25|      28|     909|     933|      21
---------------------------------------------------------------------------
  909-  933 (45.96/25.00)	CKVVKHVSNPGD.CSSAERCILAHLY
  939-  964 (40.79/21.39)	CSLLKSKPHTGEpFGNAYPKIRQALY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.85|      15|      19|     830|     844|      29
---------------------------------------------------------------------------
  830-  844 (24.50/16.13)	VAFLFDLMELALNIY
  851-  865 (24.35/15.97)	IQILKELPEVETQLY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06739 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DKILQNIKEDQQNSMDVPDSPKEHDHGHHPHQSSIGHVPMETDHNDHKVKPS
2) GMNQLYGNYGGTPNTMMPNNMQASQQMMQGSQPNMFAGQQQGFGQPRPPQPDYRGMAQNPRAQYMQQAPNVTMNANMNTMGGMGGQGGPAPPYSRQTPQGMQQGVQQPNQFQQQRMRQQMMAMQQQQQQQGGPQGNTSSLVAHLQRQMNPNPYQHQPPPYNM
3) LGPEETTDVSTSHQSHHTKLEDHSHNMDFDDAT
4) TGEDNHRLLKYHTHNLQRPPSHYLDPPPLPPEDLEPVPDKPLKDCDLKADTPSSVDQSPAAMGKGRGKGQRRPRKPKTVPGQLPVNPMGMNQPQMGQGQMPMQVPGPNPQMHNMGGYGQGPMPQQGQQYGNNQQQWYNQQQQQQGYYPPQMANVNRFERPQINQSKQALSNLLRSRHPLNMGPTAQTPQGPGPQANYGPMRSFPRQPMRQQHPGAIQQNQVKNMFPQQYGSMQ
654
1905
616
1671
705
2066
648
1903










Molecular Recognition Features






MoRF SequenceStartStop




1) MFNSSLLYEKRPLKKPKI
1
18