<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06738

Description Mediator of RNA polymerase II transcription subunit 12-like Protein
SequenceMFNSSLLYEKRPLKKPKIGPPDVYPQEPKQKEDELTSVNVKHGFLTMTHLSDEFGTARNCNISASKVGDYFNDIIKRKEELSMLPDSGRKRQQINPKDNFWPATIRTKNAIELWFKDLAGNKPLMHLSKKAPNFNKKEEIFIMLCEYQVPMMRAAWFIKLSSAYTVAVSEAKIKKRQMPDPTTEWTGTMLKFLKEQILKLQDYYSQGEKPPQTPSLTQAATTETEQKLAMRHWIYCTQLLKYMYEEGLMDRQEVLTWILELLEKMRSQPSDDGILRLLMPLCLQYLDEFVQSELLSRRLAHLCCKKLGYMLNNVAENNLITSPQSETKTEQKDNEKEKKDVPVTNPMQSTLMEYQNCPHHRDIVLQLSTVIQTITLECPTALVWCGTGVGSVWHGSPLDLLPMVPSSLPMAARCDMNTYRKQLQFAEHCIRERSKRAEGRWCTEKWQNSSAGTITNRVLAALDALDRHRFDKMDSTNSLDTLYTKVFGGNSDQENSVVKLLCEWAVSPERTGEHRALAVAALLDRRQSDSATNGDQETAPGDDKDSNCSVPGGPPMFQQLLMKFLDSDAPVPAPDDCPQKKTAFSNLVHLFAELIRRDVFSHDAYMCTLISRGDLLGPEETTDVSTSHQSHHTKLEDHSHNMDFDDATIDHDLDKILQNIKEDQQNSMDVPDSPKEHDHGHHPHQSSIGHVPMETDHNDHKVKPSRHLLYTTHFPLYQDDPFSQHDCNQRHVLLYGVGKVRDEARHTVKKMSKEICKLFSKKFSIDVAEGGKVKKHSRNEFNFEATTQKCQSLSYFDQHLVTWQCSVTVIEMLNSFATGNSNYLPVQEHVAFLFDLMELALNIYGLIDVCIQILKELPEVETQLYNKNSVLTRNYTTSLSLYVVGVLRRYHCCLLLSPEQTSAVFEGLCKVVKHVSNPGDCSSAERCILAHLYDLYSSCSLLKSKPHTGEPFGNAYPKIRQALYTALQPTPSSNYVYNSGYMQEVFTNPRRGGRIESSWARPLNESANNRYSFVSNAVIYVCRETDNERLNDLAIMCAEMTACCNSLASEWLGVLLALCCPIAHPGYYTDVLAQLDIQDVSIHNALAVFTCILIARHCFSLEDFVGRVALPSLLKVKTLDNGSGAAEGGMRLTCHLLLRLFRTAEGPQPGLYSVGSPPLTAPRPPLGVRLSCDRHLLAAAHRNIHVGPVLAVLKAVLIVGDATAREGTELSISHILGTSDLMSGGDGPSLDLAQSSTGNAESTASLSAFACHVLREICSQQWVLERCLSHPEELCDSDNLLDPLLSHSQAQRLLHMICYPDAGTSIEELDQKSMISRILENLEQWTLRMSWLDLQLMFRQFTPNSQELSQWLDTVAKAAIDVFQLNSSSSNSPKSDEKKPEIKNRAQNSIWLVAPLVSKLPSAVQGRVLKVAGQVLESGGWCKETKSKGRGGSDSQSLLSHQPFLTLVLTCLKGQEEGQREGLLSSLHQQLSQLVQLARDGNLQDICNNERTLDGLQLRFALVGGVFEAFQRNPSATTDWALLLVQLVTNGLIDLHTHSELFTTVIDMLATLIHSALATDSQDEGRKMYQNLMKKLKKEVGERHNASLQHVRQLLPLPRSVTEIIAVEPIGWVTDGKGNKISFDSLDKKHGFQVTDKQRVSSWDILEGMKNPAPLFWAWFGAVRLERKPLTGEDNHRLLKYHTHNLQRPPSHYLDPPPLPPEDLEPVPDKPLKDCDLKADTPSSVDQSPAAMGKGRGKGQRRPRKPKTVPGQLPVNPMGMNQPQMGQGQMPMQVPGPNPQMHNMGGYGQGPMPQQGQQYGNNQQQWYNQQQQQQGYYPPQMANVNRFERPQINQSKQALSNLLRSRHPLNMGPTAQTPQGPGPQANYGPMRSFPRQPMRQQHPGAIQQNQVKVRYSNIILVVPISVLLRWQLFVLKSSRHFNRVSNNFSPNKSNFCAKMDSNMFPQQYGSMQAGMNQLYGNYGGTPNTMMPNNMQASQQMMQGSQPNMFAGQQQGFGQPRPPQPDYRGMAQNPRAQYMQQAPNVTMNANMNTMGGMGGQGGPAPPYSRQTPQGMQQGVQQPNQFQQQRMRQQMMAMQQQQQQQGGPQGNTSSLVAHLQRQMNPNPYQHQPPPYNM
Length2115
PositionKinase
OrganismTribolium castaneum (Red flour beetle)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Coleoptera> Polyphaga> Cucujiformia> Tenebrionidae> Tenebrionidae incertae sedis> Tribolium.
Aromaticity0.07
Grand average of hydropathy-0.528
Instability index48.55
Isoelectric point7.65
Molecular weight237814.22
Publications
PubMed=18362917
PubMed=19820115

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coactivator activity	GO:0003713	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06738
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.10|      19|      19|    1753|    1771|       1
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 1753- 1771 (41.10/16.83)	LPVNP....MGMNQPQ.M.GQG.QMP
 2000- 2022 (22.81/ 6.07)	RPPQPdyrgMAQN.PR.AqYMQ.QAP
 2041- 2061 (25.18/ 7.46)	GPAPP....YSRQTPQgM.QQGvQQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     135.95|      19|      19|    1850|    1868|       2
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 1783- 1800 (30.58/12.61)	NMGGYG...QGPMPQqgQQYG
 1850- 1867 (33.00/14.29)	NMGPTAQTPQGPGPQ..ANY.
 1869- 1884 (21.86/ 6.53)	...PMRSFPRQPMRQ..QHPG
 1973- 1991 (28.78/11.35)	NMQASQQMMQGSQPN..MFAG
 2075- 2089 (21.73/ 6.44)	AM.QQQQQQQG.GPQ..GN..
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.56|      21|      23|     690|     710|       3
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  670-  684 (19.73/ 7.38)	.VPDSPK..EHDHGHHP..H....
  690-  710 (41.48/24.40)	HVPMETD..HNDHKVKPSRH.LLY
  713-  735 (28.34/14.12)	HFPLYQDdpFSQHDCN.QRHvLLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.02|      20|      23|     276|     295|       4
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  276-  295 (35.91/24.03)	RLLMPLC...LQY.LDEFVQSELL
  297-  320 (26.10/15.21)	RRLAHLCckkLGYmLNNVAENNLI
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.80|      20|      23|    1306|    1325|       5
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 1306- 1325 (34.70/20.33)	IEELDQKSMISRILEN...LEQW
 1329- 1351 (34.10/19.85)	MSWLDLQLMFRQFTPNsqeLSQW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.00|      18|      23|     338|     358|       6
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  338-  358 (27.83/29.18)	KKDV..PVTNPMQSTLMEyqnCP
  360-  379 (24.17/14.48)	HRDIvlQLSTVIQTITLE...CP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.05|      17|      17|    1256|    1272|       7
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 1256- 1272 (33.61/19.98)	EICSQQWVLERCLSHPE
 1273- 1289 (30.43/17.34)	ELCDSDNLLDPLLSHSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.01|      17|      17|    1686|    1702|       8
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 1665- 1681 (26.03/10.97)	LERKPLTGEDNHRLLKY
 1686- 1702 (32.44/15.68)	LQRPPSHYLDPPPLPPE
 1704- 1720 (26.54/11.34)	LEPVPDKPLKDCDLKAD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.54|      11|      17|     524|     534|       9
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  524-  534 (18.88/11.16)	DRRQSDSATNG
  542-  552 (20.66/13.02)	DDKDSNCSVPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.37|      16|      19|    1022|    1037|      11
---------------------------------------------------------------------------
 1022- 1037 (29.54/19.45)	CRETDNERLNDLAIMC
 1044- 1059 (28.83/18.79)	CNSLASEWLGVLLALC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.77|      32|     114|    1097|    1137|      12
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 1097- 1131 (50.33/43.50)	HCFSLEDFVGRVALPSLlkvKTLDNGSGAAEGGMR
 1214- 1245 (53.43/28.13)	HILGTSDLMSGGDGPSL...DLAQSSTGNAESTAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.82|      34|      55|    1564|    1597|      13
---------------------------------------------------------------------------
 1564- 1597 (58.08/34.46)	EGRKM.YQNLMKKLKKEVGERHNAS....LQHVRQLLPL
 1617- 1655 (48.74/27.71)	KGNKIsFDSLDKKHGFQVTDKQRVSswdiLEGMKNPAPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.02|      13|      40|    1135|    1147|      16
---------------------------------------------------------------------------
 1135- 1147 (23.63/17.30)	HLLLRLFRTAE.GP
 1175- 1188 (20.40/13.70)	HLLAAAHRNIHvGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.85|      15|      40|     839|     859|      17
---------------------------------------------------------------------------
  830-  844 (24.50/27.22)	VAFLFDLMELALNIY
  851-  865 (24.35/ 9.14)	IQILKELPEVETQLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.91|       9|      22|     233|     243|      18
---------------------------------------------------------------------------
  233-  243 (13.64/16.99)	WIycTQLLKYM
  257-  265 (17.27/ 9.81)	WI..LELLEKM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.76|      25|      28|     909|     933|      22
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  909-  933 (45.96/29.74)	CKVVKHVSNPGD.CSSAERCILAHLY
  939-  964 (40.79/25.45)	CSLLKSKPHTGEpFGNAYPKIRQALY
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06738 with Med12 domain of Kingdom Metazoa
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