<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06736

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHPNFQTNGASLEDCHTNFFALTELSGIKWRKLVYCELGGGGAASGHCSGGGGGGEPLEDPVLRSYARCLAADILCVWRRVSTPRSTDMFEPGPPPPPPLSLSTSKELWIFWYGEEPDLGVLIAPELNTPDSEQGSWESGLSYECRSLLFKALHNLIERCLLSRDFIRLGKWFVQPYEGPKKNDFTMTHLSFSLAFFVHGESSVCASVDVRQHPPVRRLTRLHLQQAQSSTSGLKVILAPYGLAGTLTGQSFKSSDQTSRLLEDWSHFYPLDKSSSLTDSSVVEVIVGGVKMKYPSCYVLVTDLDDNVNSAMNCTGVNPPNGLVKNGTSSPILTQTPPPSPIQINSRVPQPGPYSVSVEHLLSMSRDETAATVLPERAWQECIHGGPPGCTPQPTSNTPHEFTGQWDFVDPIKRANCTCSKCRKYVGSMTSNKWSTGATTKTTNSPRPSKAVRGRVPFHRRSPVPADSDRCSGSYTPQGGPPSYPRTQESVAIPSVGSPPSVAPSPLPNPHSQPASVPPGDQTMPMLSPHPPTLLPSPVEKTHTPDHPPKSVESTANSPSCPTDAKNEQVTNVTSVPVLKRPVLSVKEYESSLGDEEQTLEMLYDYSTLEAWLNHPVKRFKPDGKENKRNRLGKNDIYSMYNHNGVTVNNNDVTNNFNTKNQFIKQEIKQEMTESESTTPLGPMQGHGVKRPGDPYEFDEEGAGSACIDGFKRGQTVVKEEPKDSKKISTGNLFTSEGLQPSYKDLEQIFDNNSDDTSSDEAIQVQTPPGSTTLNHHEDNKRLSGHGGCPTMGCLRPEELSKMFPTPPSLEHNPIASPCGQMDLALPDYTDLGIVRTKQEIYPNMGSPPEEHIDDWTYVFKPPVLCKMVGSSKYAPLTNLPSQSLPVVTLPSYCVYKPSWIQHAEKPLQQLPPPSTTQPSIPNNLHQNSFPPSPLHGGFRQPPPPYELPSPATSTASSYLNKNLNSVEAVPTPSVQRTPEANSLALNILLTDTASNIFRDHNFDSCTLCVCNAGGRVVGNIRGADAGVYLISSSCDKTQSSVQQPSSPFPGACLGQPPPYGMLSPPHHHQQQLLVDEDGIRCSCGFSAVVNRRLAHGSGLFYEDEMEITGIAEDPGEKKKPSLLSFLIASNSIKLDPSIDRDQVDVLPHGLLELIREQCVVIPNTANALCRAAKYVCTKQTFNNIHVLEYSDSNEVTTIALEQSKSSYDLAVCKVEDKAKPAVGYAVHRWPFLRANGPQCNQDIVRVMRSLQPLLQEAIQKKCQTRLWEAPSAVKGPLTWRQFHRLAGRGTDDRCEPQPIPSVVVGHEKDWLSVSPYAIQHWESLLLEPYSFARDVAYIVVAPDNDAILPRVRTFFKELSTAYEMCKLGRHSPITKVLRDGILRVGKTAKAKLGNEPVEEWFTLLGEGEITDMLKLYAQVCKHHLAPHLQQVPMDKTLLDPPQESGDKPAPSPMPPPSTPDGGQAAEKAPSTPKSDQDGDGMKESTPQANTNAENSYDEDEREVPSVVVYLVEPFSLGSDQPELQRLACLALLRCFQSVLAAVPENIRNNISVQIISLESIVELGRARDRTRLSDHMRALSLNIFSQCRRLLVHTNNVKSLTGFGTAAMADLFLKSKDDKNRAAYKLYTPPYILAPMHEKIEAVESFGKGSGDQASVLYLSYCLSEDQSWLLAVATDERGEIFETVTINIDIPNRSRRKKASARRIGLEKLMNFILGVMSQSVRPWRLVVGRLGRIGHGELKGWSWLLSRKNLLNASKNLKEICNQCSLMYPTSVPCILSACLVSLEPDSVLRLMPDQFTPDERFSQVSVNSQLSTPQDVSCTHILVFPTSATTQSSQTTFQEQHITPELGDDELFSAFTAEDMPEGIDSMNDFSDIFNWTDTGPGGGQSPTGSPRREESGPGSPNCGVNNGRPGSPFHCGATNSKGNEQVEEVGTLLQQPLALGYYVSTAPTGRMPKWFWASCPHLEGICPAFLKNALHLHSPSIQQSSDDLFQQAAVTSHPLDSQYTTDVLRYVLEGYNALSWLALDSNTKDRLSCLPVHMQVLLQLYHTTAALL
Length2058
PositionMiddle
OrganismTribolium castaneum (Red flour beetle)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Coleoptera> Polyphaga> Cucujiformia> Tenebrionidae> Tenebrionidae incertae sedis> Tribolium.
Aromaticity0.07
Grand average of hydropathy-0.441
Instability index55.44
Isoelectric point5.90
Molecular weight226026.63
Publications
PubMed=18362917
PubMed=19820115

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP06736
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1615.22|     419|     427|      93|     519|       1
---------------------------------------------------------------------------
   44-  327 (352.79/139.42)	............................................................................................................................................................AASGHCSgggGGGEPLEDPvlRSYARclAADILCVwRRV......................................STPrstdmfePGP......PPPPPLSLSTSKELWIFWYGEE..PDLGVLIAPEL.NTPDSEQGSWES.GLSYEC.RSLLFKALHNLIERCLLSRDFIRLGKWFVQPYE...GPKKNDFTMTHLSFSL.AFFVHGESSVCaSVDVRQHppvRRLTRLHLQQAQS..STSGLKV....I.LAPYGL..AGTLTGQSFKS....SDQTSRLLEDWSH..FYP..LDKSSSLTDSSVVEVIVGGV.....KMKYPSCYVLVTDLDDNVNSAMN...CTGVNPPNGLVKN
  328-  749 (606.63/241.33)	GTSSPILTQ.TPPPSPI....QINSRVPQ..PGPYSVSVEHLLSMSRDETAATVLPErawQECIHGGPPGCTPQPTSNTPHEFT.GQWDFVDP.IKRAN...CTCSKCR..KYVGSMTSNKWSTGATTKTTNSPRPSKAVRGRV...PFHRRSPVPADSDRCS...GSYTPQGGP..PSYPR..TQESVAI.PSVG.................SPPSVA..PSPLPNPHSQpASVP.pgdqtmPML......SPHPPTLLPSPVE....................KT.HTPDHPPKSVEStANSPSCpTDAKNEQVTNVTSVPVLKRPVLS.....VKEYEsslGDEEQTLEMLYDYSTLeAWLNHPVKRF..KPDGKEN...KR.NRLGKNDIYSmyNHNGVTVnnndV.TNNFNT..KNQFIKQEIKQemteSESTTPLGPMQGHgvKRP..GD.PYEFDEEGAGSACIDG.......FKRGQTVVKEEPKDSKKISTGNlftSEGLQPSYKDLEQ
  759- 1150 (523.60/200.65)	SSDEAIQVQ.TPPGSTTlnhhEDNKRLSG..HGGCPT.....MGCLRPEELSKMFP..........TPPSLEHNPIA.SP...C.GQMDLALPdYTDLG...IVRTKQE..IYPNMGSPPEEHIDDWTYVFKPPVLCKMV.G....................S...SKYAPLTNL..PS..Q..SLPVVTL.PSYCvykpswiqhaekplqqlPPPSTT..QPSIPNNLHQ.NSFP.......PSPlhggfrQPPPPYELPSPATSTASSYLNKnlNSVEAVPTPSVqRTPEANSLALNI.LLT.DT.ASNIFRD.HNF.DSCTLC..VCNAGGRVVGNIR...GADAG...............VYLISSSC............DKTQSSVQQPSS..PFPGACL....GqPPPYGMlsPPHHHQQQLLV....DEDGIRCSCGFSA..VVNrrLAHGSGLFYEDEMEIT..GIaedpgEKKKPS...LLSFLIASNSIKLD...PSIDRDQVDVLPH
 1151- 1332 (132.19/44.36)	GLLELIREQcVVIPNTA....NALCRAAKyvCTKQTFNNIHVLEYSDSNEVTTIALE...QSKSSYDLAVCKVEDKAKPAVGYAvHRWPFL.....RANgpqCNQDIVRvmRSLQPLLQEAIQKKCQTRLWEAP...SAVKGPLtwrQFHRLAGRGTD.DRC.......EPQ..P.iPSVVV..GHEKDWL..SV..................SPYAIQhwESLLLEPYS................................................................................................................................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     247.44|      72|     342|    1384|    1475|       2
---------------------------------------------------------------------------
 1384- 1460 (118.87/66.21)	LRVGKTaKAKLGNEPVEEWFTLLGEGEITDMLKLYAQVCKHHLAPHLQQVP..MDKTLLDPPQESgdkpAPSPMPPPST
 1729- 1801 (115.25/52.64)	LVVGRL..GRIGHGELKGWSWLLSRKNLLNASKNLKEICNQCSLMYPTSVPciLSACLVSLEPDS....VLRLMPDQFT
 1919- 1939 (13.31/ 7.81)	FHCGAT.NSK.GNEQVEEVGTLL........................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.30|      11|     426|    1461|    1471|       5
---------------------------------------------------------------------------
 1461- 1471 (21.20/ 9.76)	PDGGQAAEKAP
 1886- 1896 (23.09/11.38)	PGGGQSPTGSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06736 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DGFKRGQTVVKEEPKDSKKISTGNLFTSEGLQPSYKDLEQIFDNNSDDTSSDEAIQVQTPPGSTTLNHHEDNKRLSGHGGCPTM
2) EKPLQQLPPPSTTQPSIPNNLHQNSFPPSPLHGGFRQPPPPYELPSPATS
3) HPVKRFKPDGKENKRNRLGKNDIYSMYNHNGVTVNNNDVTNNFNTKNQFIKQEIKQEMTESESTTPLGPMQGHGVKRPGDPYEFDEEGAGS
4) NSAMNCTGVNPPNGLVKNGTSSPILTQTPPPSPIQINSRVPQ
5) QVPMDKTLLDPPQESGDKPAPSPMPPPSTPDGGQAAEKAPSTPKSDQDGDGMKESTPQANTNAENSYDED
6) SMNDFSDIFNWTDTGPGGGQSPTGSPRREESGPGSPNCGVNNGRPGSPFHCGATNSKG
7) TSNKWSTGATTKTTNSPRPSKAVRGRVPFHRRSPVPADSDRCSGSYTPQGGPPSYPRTQESVAIPSVGSPPSVAPSPLPNPHSQPASVPPGDQTMPMLSPHPPTLLPSPVEKTHTPDHPPKSVESTANSPSCPTDAKNEQVTNVTSVPVLKRPVLSVKEYESSLGDEEQTLE
710
906
616
310
1432
1871
431
793
955
706
351
1501
1928
602










Molecular Recognition Features






MoRF SequenceStartStop




1) YKDLEQ
744
749