<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06734

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFLKACITNIHAVENLVQTAYCVYDWAEGQVASAAAAERWEHAQNTLTTLRRENVLCTSIAHAVWIFGHFNADQKNTLDNTHSAFSLSQEGTLENPPTHAPSGRAVRDILLDAIQHALAFTLARDPAIVHVGPWLWLYHSVCHNEEDDDNEHALRQLRDTSIIHVYTKFTPSGGLYLIPNIMPSSVQPLPALPHCESKDVVLAPFGTLATVLPEFHDDSVLSDDAWKTGLAKALEPHGIDLHAGTSWIAIELAGDTETTACVWPASLCFTPYRPRRMQDHTANADRDWRRWFISTEEGTIFRNPLGMAEEWFKGAAERTRTGANVVEAQATVQSDEQILTEPIAASIAAHDATTMTSPPFSQRAVDQQAAMAGIYPTPPDGYVPMPNVSQLNSTTPSATQPEQIASTVDMAPTSDDVQYKHEESHHVEPNTFGNEDQDMLFGDEGEMEDIGDADFSFFDDPDNDPAMLSMRGGDLEDALKYEDDADDANLDTNINDAAIEDLQPPLDAGPSEDTTRSETIEHIPIEPAEHMQKASQSPTVVSVPQFGHSIVEPEKPLSPFGIRERLLPPPVPASFTQNGAPEHSESRRASTFAPINFREGLNLSRKYALVTAAPEKEPLRPGTISTSGIGLPSARKKNRIDDNDSSDSDTDDESEGTSYEPSSSDMDDADLPPRLPWESRKRKRHADLDNFHRLSGSLERMWSDDEADDRRAVLGMQTPIADVLAAYVSSTPAVELLTLFKADSEVAGADHPKSSAGPTDSMEALSGPLPRMDLLYGFAKEDLIYVSQIINEQSLSALQVDGTRVDVHEDGVAELPIGIANYIHTTIERGIQTVFPDIDQCDLGKVALTREPLRAPANPGKAPQGLPRPPPRIDSMLLGPDYFHLPPPYVRLQRSSEIWEMLPTCLTFWETLGLGPTNGAKNVRAFCVFPENEDLQRLVESFMTDLGAAYENCKLGSHSHHRNASETDENDTFEDGMAPVELNEDASLEGAMISYATTCADLGKALSNIAHQENDRAIVIYILNPFFGRQAQQHLCACFWILFKAYRDNLPKAQRNQAGSDIFLQCLPISLVASYDALVVPDARQMAILTREVYDRCPPCGPSFDNTSALPILSAPSVELASAAPKRIGFQLAAEPPNDLLHEGSILHIAFSVSKDGQWMSVCWIDNTGRHQSSTAFCLRGRSLAEVIEDVWECTRDILAARQVLWRIFIVTTDAIEKSVLQCWRSFSAKPRTQAICVTLLAIDTDPVLQLSPPMANVDSQIESRSDGGFLTPASTPQAGTFTSSPDVNGQGGNAPPTPAPSETAASAAENDPDAHLTDLTDETWGVLLSPRLNNVGSNVGLANGALFKRGDVAVPDGEGTAADKLPSIGVSIHWTIQVKPSGGVDEGSVKQAELTLREVLRMYRNLALLTKARAIANGKMDFVPIHVAAAVRGAEGLDGMLGSSEDM
Length1449
PositionKinase
OrganismPseudocercospora eumusae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Pseudocercospora.
Aromaticity0.07
Grand average of hydropathy-0.331
Instability index47.39
Isoelectric point4.65
Molecular weight158046.66
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06734
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.50|      25|      34|     534|     567|       1
---------------------------------------------------------------------------
  543-  567 (46.07/35.91)	SVPQFG...HSIVEPEKPLSPFGIRERL
  575-  602 (38.42/14.60)	SFTQNGapeHSESRRASTFAPINFREGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     144.40|      32|      32|     453|     484|       2
---------------------------------------------------------------------------
  452-  483 (59.46/29.46)	GDAD..FSFFDDPDN....DPAMLSMRGGDLE...DALKYE
  484-  513 (39.25/16.98)	DDAD..DANLDTNIN....DAAI.....EDLQpplDAGPSE
  642-  679 (45.69/20.96)	DDNDssDSDTDDESEgtsyEPSSSDMDDADLP...PRLPWE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.00|      18|      34|     113|     132|       3
---------------------------------------------------------------------------
  113-  132 (27.30/23.75)	DAIQHALafTLARDPAIVHV
  149-  166 (32.70/20.89)	DDNEHAL..RQLRDTSIIHV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.26|      27|      34|     817|     845|       5
---------------------------------------------------------------------------
  817-  845 (45.16/32.12)	PI.GIANyiHTTIERGIQTVFPDIDQCDLG
  853-  880 (47.10/26.89)	PLrAPAN..PGKAPQGLPRPPPRIDSMLLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     533.26|     175|     898|     213|     413|       6
---------------------------------------------------------------------------
  213-  413 (277.51/194.24)	LPEFHDDSV.LSDDAWK.TGLAKALEPHGIDLHAGTSW.IAIELAGDTETTACVW.......PASLCFTpYRPRRM...........QDHTANADRDWRRWFISTEegTIFRNPLgmaEEWfKGAAERTRTGANVVEAQAtVQSDEQIltepiaasiaahdattMTSPPFSQraVDQQ..AAMAGIY..P..TPPDG.YVPMPNVSQLNSTTPSATQP.EQIASTVDMAP
 1111- 1314 (255.75/134.75)	LPILSAPSVeLASAAPKrIGFQLAAEPPNDLLHEGSILhIAFSVSKDGQWMSVCWidntgrhQSSTAFC.LRGRSLaeviedvwectRDILAARQVLWRIFIVTTD..AIEKSVL...QCW.RSFSAKPRTQAICVTLLA.IDTDPVL................QLSPPMAN..VDSQieSRSDGGFltPasTPQAGtFTSSPDVNGQGGNAPPTPAPsETAASAAENDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.97|      31|      55|     932|     965|       7
---------------------------------------------------------------------------
  932-  965 (50.97/45.97)	ENEDLQRLVESFMT...DLGAAYENCklgSHSHHRNA
  985- 1018 (47.00/33.19)	EDASLEGAMISYATtcaDLGKALSNI...AHQENDRA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.52|      33|      36|      30|      64|      10
---------------------------------------------------------------------------
   30-   64 (45.69/33.63)	GQVaSAAAAERWEHAQNTLtTLRRENVLCTSIAHA
   69-  101 (56.83/33.03)	GHF.NADQKNTLDNTHSAF.SLSQEGTLENPPTHA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06734 with Med13 domain of Kingdom Fungi
Unable to open file!