<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06729

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMADLPDASMMDGAMDDLFGEAPVGLDGGIAMPPAPLPASLILRIAEMQSRGCCTVTRKLAWSNVGSIAQICPDGSQVTFRTMIRDKKTGTWTISDDSKYPFKAPDGRKFVHIQFSGIGVDLVVVDDAGHVHLPSMTGAMGKMSTTQGELARDDSKHELNAIVGLHWLALFPAEFRGPYIDAAHKNGDRWDATMKQRDQQGLRAHHPAESRHAFLHISRSTELTLCYQNEGQGWQSTSVMLDTPRTSDGLVTHAALGEDNSDLLAVTYDTASRLRLYRVSIVWNASQQSRGPGVNFLRVEPTLDVHHLTAVNNVRPQQIDAAKLTHLRIIPQVAEAAQQVPTLPNILAIFTHAAFPSHTSPDQSSTSVIARWSVETFAPTLHESFTKLKPGGNTNQVLHQITVLKRQPDVSTNGKVILTFESQMFDTILAFANSDGSLDLRDRITMEPLGPFGSTDTVSNLHQSGFDHVPGEHNLHVAMSVDGSALVYVRVDKKIDAQCMKLTRGWHVVDDGISDDRPYIEAAAVCIARQFAFLCYNNMATDETLALLPPDASPELRSLVVRMIFRMLNRSPDISMQESSRQQMIVLKEPLVPRCLSAQLALGTNPMTGERNFAAQYAFAVLNLRLAGTALASTCGRSDVKQISPEAVHFARGLVRWCMDLIVYIVNTIVTIQRDVKAGSTAKKVIDKLTSTSGSPALHLLLCSFSRTLVRFQTIWVVKYFQCLQHVVPRIRSVTERQEMEAVFSLAGQLPFKLQQFEGMVVEVDQVVRQAYTKSNLSADRRGELEINMMVDGTIPPELEPAVNSLLETTIPKLTENMDLGKLHFYDTSFLQLWTNKRENHGRIIDVLRKVQVPLDAALRTCRRCGSEMEDIPPEKLRQELFAGWFHHAQRYCVCMNYWFVA
Length901
PositionTail
OrganismPseudocercospora eumusae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Pseudocercospora.
Aromaticity0.07
Grand average of hydropathy-0.151
Instability index40.08
Isoelectric point6.51
Molecular weight100114.53
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06729
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.39|      48|      75|     300|     374|       1
---------------------------------------------------------------------------
  300-  354 (64.65/101.36)	PTLdvHHltAVNNVRP....QQIdAAKLTHLRIIPQVAEAAQQVPTLPNilAIF.THAAF
  378-  430 (72.75/41.59)	PTL..HE..SFTKLKPggntNQV.LHQITVLKRQPDVSTNGKVILTFES..QMFdTILAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.35|      15|     127|     738|     758|       3
---------------------------------------------------------------------------
  738-  758 (22.43/26.23)	EMEAVfslagqLPFKLQQ..FEG
  867-  883 (24.92/13.73)	EMEDI......PPEKLRQelFAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.21|      26|     548|     272|     297|       8
---------------------------------------------------------------------------
  272-  297 (45.87/32.94)	RLRLYRVSI..VWNASQQSRGPGVNFLR
  821-  848 (42.34/29.79)	KLHFYDTSFlqLWTNKRENHGRIIDVLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.53|      21|     308|     456|     482|       9
---------------------------------------------------------------------------
  456-  482 (26.59/35.61)	TVSNLHQsgfDHvPGEhnLHVAMSVDG
  772-  792 (38.94/24.20)	TKSNLSA...DR.RGE..LEINMMVDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.42|      25|     549|      58|      84|      16
---------------------------------------------------------------------------
   58-   84 (42.41/29.51)	KLAWSNVGS......IAQICPDGsqVTF.RTMIR
  624-  655 (32.01/16.28)	RLAGTALAStcgrsdVKQISPEA..VHFaRGLVR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06729 with Med16 domain of Kingdom Fungi
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