<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06725

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSNSDSERSPKRQRLNSYSPASTGCPSPKRQRTEQPFIQTPPPSVRMSPSWQSQSQQILHHSGGSNFPSPPSTAGYQNRMAEGGGDSGRQTPASQDDSELRRDVDGDAVMRDQREGTDADIHMADPEHRRSDHERLGGSGEVEPLPRFKVFAAPVPPSRPHPSQDLIELYGLKRIQANVRRRDPVTGAKINTMRKSYANKLKTLGLEGRNKAVPNQGELSGLLDPGWSQEMQPGSGVTLWDNNWSERGKLGDSNAEADLLSKLDAALKMGPGQLPGKERESWNNVLGLDDPSVPSKGATATAKAPLASNPALAKTSAAHAMSSSAPASPRNQIRPDRKGKKRSYDDSSFEGYNQGYDDDGYSTGGLDDTGRRRDASKRQKRKVSSTPKHT
Length390
PositionHead
OrganismPseudocercospora eumusae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Pseudocercospora.
Aromaticity0.05
Grand average of hydropathy-1.107
Instability index69.95
Isoelectric point9.48
Molecular weight42456.27
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06725
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.12|      13|      16|     214|     229|       1
---------------------------------------------------------------------------
  217-  229 (23.88/15.57)	GELSGLLDPGWSQ
  234-  246 (25.23/ 8.62)	GSGVTLWDNNWSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.41|      17|      18|      48|      64|       3
---------------------------------------------------------------------------
   27-   43 (29.59/14.67)	SPKRQRTEQPFIQTPPP
   48-   64 (30.71/15.49)	SPSWQSQSQQILHHSGG
   69-   85 (29.11/14.31)	SPPSTAGYQNRMAEGGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.93|      21|      21|     135|     155|       4
---------------------------------------------------------------------------
  135-  155 (36.32/28.55)	RLGGSGEVEPLPRFKVFAAPV
  159-  179 (36.61/28.85)	RPHPSQDLIELYGLKRIQANV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.61|      23|      77|     287|     310|       6
---------------------------------------------------------------------------
  287-  310 (35.51/17.96)	GLDDPSvPSKGATATAKAPLASNP
  365-  387 (38.10/16.05)	GLDDTG.RRRDASKRQKRKVSSTP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06725 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LSKLDAALKMGPGQLPGKERESWNNVLGLDDPSVPSKGATATAKAPLASNPALAKTSAAHAMSSSAPASPRNQIRPDRKGKKRSYDDSSFEGYNQGYDDDGYSTGGLDDTGRRRDASKRQKRKVSSTPKHT
2) MSNSDSERSPKRQRLNSYSPASTGCPSPKRQRTEQPFIQTPPPSVRMSPSWQSQSQQILHHSGGSNFPSPPSTAGYQNRMAEGGGDSGRQTPASQDDSELRRDVDGDAVMRDQREGTDADIHMADPEHRRSDHERLGGSGEVEPLPRFKVFAAPVPPSRPHPSQDLIELYGLK
3) NKLKTLGLEGRNKAVPNQGELSGLLDPGWS
260
1
199
390
173
228










Molecular Recognition Features






MoRF SequenceStartStop




1) PKRQRTEQPFIQTP
2) PLPRFKVFAAP
3) QDLIELYGLKRIQANVR
28
144
164
41
154
180