<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06721

Description Uncharacterized protein
SequenceMDNRPALGLQRPLPPQRALTGSYALQHALKRTPQPSRLNNVRSVSQPVNIVDLTADGARIDARNAAAFLNNADRLYASPHVINLDDDDKQRPAKRAKTAGRGFRAGGNISEAQRDAAHQAVPGSPLPSLPPRKSVIASRNTAQRSRRALVHRAARRANGLEPPSIATRLPAPKLVADFHPWNGHHAEDILTETVVKGGYFDKAPAPNSAETTSAKPTIWSNLSAKNNMGLQTLSYLFTSVMEKRQAMGRVTAPSTFKPPPRVTVTDTKREAWLRDLANPDVPLRKQSRTIPHGVRGKLLMEQCLGKDIPMPRAVWLAKCVGANELRAFRRKGVSGAAAATGEAKWVREWTVSVEQFLDGVIACCGQAEWQLKMDYAVKLATSFYTERLLERHHYLDWIVTSFAQAPLERLPIWIILAQLYWKDITAFGRRGRQLAEAILGNLHSMSQARLFVNDTLKARLHKLLMILAATNRGCLILPKTWQKYGYLLAPRTATPNDTPAHNILRRNARLVAPLLKTPQNTRCALLRLYSMLDSVALCLDVAKLSAACLAAVRDINRLVSALLNWSASVFRPGLCRIYLAGQVMSQLRKDGQDTDSAILGYLGSDPVNSVASEHVHRVLVELVRRDAFSAGRYMQWLISSGALSGGHGSSMATALLPMLPRGALSPHLLNTRHTLMNRLKMIPNGDEALASVEAAVLSSAESSQDIRSTVQQLSSFAKLELAERLVARVVVWAKDGGMSLPHFCCLRDTMETIGDLQALATILEASIHTDDTALLATICDTISMYGKAFAAIGCLQSMVDRVSERYRILRAQQALDRSFILALTVLLSRFPEKAQFIKYLDSDLAICDQQTSLAVCSPASDNLISMHASSLDSDSDIDSVFASGNTMDEHLMQRVFSRIVQRAGKASAQLDHGSTKICSWLNQLRAVDANNFDSMARSYAIAAIKNTGENTSMLTVICALVAGGCLRFDFIIDLAKETKSSAAASSAVRLLCSTTIINGALHPVEAYRYRVQQKRFRRESAEKVIPLLVLAIEDPRVAIDDDGFHNLVMEYAVYKYADCIQALRDAPSSSAFLANCGRLVTKMLNLGRSGTQPVSLDVKSIVALADPLSVVQCTGALAFLAKAGDDNDTELLPAVLEAIANGCEVWPQLLEVANQQTIAGIYKWAKEQVLNNASKQDGVESMSREEFSRVLDILDVAHHAAKGEDSSSIIGSVTEKLRALEPRLSGFTEAVVEERQRVMFTLQVLMHLTILYSSSASPDNDAGKQTRCNLLAAVCMILVHPGLQSHQEILEYIHDAASTLADTLPAEALASLGQSILRNGKSDPRLASILGTSPPPDAWLALVSQPQPQGSSQARALMKQAANQQQMAGRGNLPSPVQQTSSLQKAALRSDGRSLAETKTMPFALRRWEIMSDATPMVGDNDTSLSLSLFGARKV
Length1435
PositionKinase
OrganismPseudocercospora eumusae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Pseudocercospora.
Aromaticity0.06
Grand average of hydropathy-0.108
Instability index46.97
Isoelectric point9.18
Molecular weight156630.16
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06721
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.47|      28|      72|     662|     695|       1
---------------------------------------------------------------------------
  662-  695 (39.07/38.65)	GALS.PHLLNTRHTlmnrLKMIpnGD.EALASVEAA
  736-  765 (45.40/26.56)	GGMSlPHFCCLRDT....METI..GDlQALATILEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.20|      39|     430|     871|     921|       3
---------------------------------------------------------------------------
  126-  164 (68.04/36.88)	LPSLPPRKSVIASRNT.....AQRSRRALVHRAARRANGLEPPS
  871-  914 (61.16/59.44)	LDSDSDIDSVFASGNTmdehlMQRVFSRIVQRAGKASAQLDHGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     270.56|      85|     429|     539|     658|       4
---------------------------------------------------------------------------
  349-  448 (130.43/77.96)	WTVSVeqFLDGV..IACCGQAEWQLKMDyavklatSFYTERLLERHHYLDwIVTSFAQAPLERlpiwiILAQLYWKDITAFGRRGRQL.AEAILGNLHSMSQA
  565-  652 (140.13/107.86)	WSASV..FRPGLcrIYLAGQVMSQLRKD.......GQDTDSAILGYLGSD.PVNSVASEHVHR.....VLVELVRRDAFSAGRYMQWLiSSGALSGGHGSSMA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.80|      19|     430|     712|     735|       5
---------------------------------------------------------------------------
  712-  735 (26.23/23.90)	QLssfakLELA.ERLVARVVVWAKD
 1148- 1167 (29.57/15.40)	QL.....LEVAnQQTIAGIYKWAKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     153.40|      45|    1056|      38|      88|       6
---------------------------------------------------------------------------
   42-   88 (74.29/58.55)	RSVSQPV.....NIVDLTADGARIDARNAAAFLNNADRLYAspHVINLDDDD
 1065- 1086 (22.00/ 7.04)	........................DAPSSSAFLANCGRLVT..KMLNL....
 1088- 1128 (57.10/29.98)	RSGTQPVsldvkSIVALADPLSVVQCTGALAFLAKAG...........DDND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.67|      26|    1056|     304|     331|       7
---------------------------------------------------------------------------
  304-  331 (40.91/30.53)	LGKDiPMPRAvWLA.....KCVGANELRAFRRK
 1330- 1360 (43.75/24.02)	LGTS.PPPDA.WLAlvsqpQPQGSSQARALMKQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06721 with Med12 domain of Kingdom Fungi
Unable to open file!