<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06713

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMLSKGTYARFPTIVQEKIRLAQPKPPKDEERAATISLVEDTISSMLAFSELVPSRLRKGFRGIENGKAVFCVEGEFEVSLTVHPRDLPNTPIIGPSTTFPLSPPSEEDRDRVVWGWKVLDVIIFVGGTDVSKHWEDPHRKEELRLAAQARVDAAHALTQILEDAQTAENEANLLESDAASLVGSTTSSGVFRLPPIQQKQLQQLRQFQASHAAFRVTSNPALPRRKTKWPLVELYDYLHTWALLQQIEFLFSQRLSESRWLKEVEIERSVDDWGHPVLRGRFWRNPSVGLGGYGKDETSSFDKQLRRRNVLEVSIKIPNDEVSRPTGRVRPRSKRWSGEETETWDVEGDQPVATGPENLFGREKPTLVAEPKFLEEAEFELDAHVIRAMRPSIRTSLTGPRTELDQSHGPLATCYDSFLSLRAYLAADGAKQPFLPGEMLHDFIIPAVFSIDIRNLSLESMLNAAAGGASRLFLKRLQTLLEVVQFPVTVVGNMDALDVTYVQGKSVRVAVDGGTGRVLVTPKGESFTIATNGNNRLMSRMTALSKVMNESPINNIDNDVSAAAKNPMVVALRTLGCDIMVDALERFGSYIGLRPQRRIPLNTESLVFLNSQETSFGPNPIRADLFQDTWEQPSVDHPEHIVYLQFPSFPLWYLAIRVTPSSLSSNTSQLSPLAFSYSAWLLAITSSRGKQATSLEPRNVIEDEFALSFGERIDMHRVEQVLVGIRVQEGLEDSGAVPSPASSSVELPDISSKSGQIEADADKKRKRSTSEPENETPKRPRLSQQFTENAFQTSQLLDILTRTPELEISMPELATILQEMELSHQPSVETELFSYTPVGGSIPLHILSCIERLCRRRITIQELEDQLRDQGVQSKIHNPSRVAPNSGERPLAALGTWSVKVPVSELLKHPWNTDKVAELPADDHLLHVVSPSWSSIVNASQHPLSGSEASFSRKSDESHARCSLPFTVSSLYIHPYNETADLFSADEAQTKMRVVAAMRLRKENLPQISDSELKLSSDTLLWRHDRIDSCIPWIISNAGGVAFIATLAAQCKQRSEVLSRNGFVLSHYSVNELGLRYRGWSYDQEFTLVIRLNVEFEGTGIEGSARTGNPCQVQFGVVNGRDEDNPHLLVANHVSTTLARSCDIVQMAKFLRVTWKVFSSVGLSVSTPGEKLLTVYPLSERHLRLLSTSGDFGVDVMVLSDRVGMLCDTSFVTPWTKAYPVHPPTSRIPGFQMIEADVLQIALRDMESASASVLPLPFGIVVPLPLLSSAIDTFKKILRVLKAVYSMEHFGERRQSNETDVPHPNSRNQSTIPDSVEVIVKLDPVFIEFHGPIVKCELSVNWESNLTWSATFEVDDDRKVAHQNPAPVTSSADLDHHLNNLGSCMSQQLTSTPHLDLVPLFVSMANLVAVHTDVIVDIAMLLCPSKKV
Length1428
PositionTail
OrganismGonapodya prolifera (strain JEL478) (Monoblepharis prolifera)
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Chytridiomycota> Chytridiomycota incertae sedis> Monoblepharidomycetes> Monoblepharidales> Gonapodyaceae> Gonapodya.
Aromaticity0.07
Grand average of hydropathy-0.240
Instability index45.79
Isoelectric point5.72
Molecular weight158903.61
Publications
PubMed=25977457

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06713
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     196.33|      58|      63|     902|     961|       1
---------------------------------------------------------------------------
   86-  111 (20.73/ 7.84)	.........................................DLPNTPIIGPSTTFplSPPSEE...DRDR
  902-  961 (100.05/88.58)	P..VSELLKHPWNtdKVAEL.PADDHL..LHVVSPSWSSIVNASQHPLSGSEASF..SRKSDE...SHAR
  965- 1026 (75.55/58.51)	PftVSSLYIHPYN..ETADLfSADEAQtkMRVVAAMRLRKENLPQ..ISDSELKL..S..SDTllwRHDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.03|      34|     157|     618|     677|       2
---------------------------------------------------------------------------
  632-  670 (50.31/69.01)	QPSVDhPEHIVYLQ.fPSFPLWYLAI.......RVTPSSLssnTSQL
  825-  867 (50.71/14.89)	QPSVE.TELFSYTPvgGSIPLHILSCierlcrrRITIQEL...EDQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     272.58|      85|     112|     223|     311|       3
---------------------------------------------------------------------------
  223-  311 (138.06/113.08)	PRRKtKWP..LVELYDYLHTWALLQQIEFLFSQR....LSESRWLKEVEIErsVDDW....GHPVLRGRFwRNPSVGLGGYGKDETSSFDKQLRRRNVL
  331-  425 (134.52/93.22)	PRSK.RWSgeETETWDVEGDQPVATGPENLFGREkptlVAEPKFLEEAEFE..LDAHviraMRPSIRTSL.TGPRTELDQSHGPLATCYDSFLSLRAYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.00|      17|     153|    1186|    1202|       6
---------------------------------------------------------------------------
 1166- 1186 (24.02/12.78)	STPGEKLLTVYPLSERhlrlL
 1187- 1207 (25.98/14.41)	STSGDFGVDVMVLSDRvgmlC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.96|      42|     580|     140|     182|       7
---------------------------------------------------------------------------
  140-  182 (60.09/43.88)	KEELRLAAQARVDaAHALTQILEDAQTAE..NEANLLESDAASLV
  702-  745 (64.86/43.00)	EDEFALSFGERID.MHRVEQVLVGIRVQEglEDSGAVPSPASSSV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06713 with Med14 domain of Kingdom Fungi
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