<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06706

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMRARKDEKKLPIYESQPPKWLPKSHATADLGYPGFFPPRPGQDEDVLSEARVRTGFVLGHQVSAETFSAQAIINENLNAGDTLNKLEDLINEVFKRRADRVPTIPPSSFRMPTRVTLSETKKQAWFADLAKPDVPLAKLGKSVPHERKDHGLLDLLYQHNVAIPRAVWFLRVSGANETVGYRSKNPSNPAQHSIEWANVMTGYMKKQLNEIALPSAPRPGLNIKQTFKGVLADAEGREKWISRFSYCLKLLRTFYTEGLVDHRSFLIWFVNQMGACNLAQVGFLSRLADDYLAPIMTSRALAKPFVEACLNKLSEIRETAQEYLFDIEKQLRTTLQRICLALPDAFVCPRMWLTHSSLIMNVMDTDIINIPSGSERFTDRAVQEIRRSISDNLYDIQKRNEAILFHDPPTKGIGRLGTAVIDVKLLNSISATTDMTSVAFFQNELDNTPAFKEKLDMLLTWSVTPLQYGDHRPFAAVTLIWLWRDRACERATRRDIETPNDFLQDQLFDWLDTSESAGDAKIIRDIALLYGKLVKQELFSYPKYIQRLIARGETGLSFTESVESRHRQFLRWIPLHNSTLSELNQRRVTLYGVRARETPEDVAEREIRKEIRLILPELFGEQDDSTVPNFIALLDRCRTLVDSTRFEQTRIFRQWFLPRLRQQVTNPESSITSSALLRIYCISVELMFYSKCFDCILDLTLHMLTNTKYPELLVAIIDTLHRFATIWSCMNVRQEIVLALDTAHQARKTQGAQSRGLLSLLVEFDRDQLYLSPASRERIDSDLAHFTLALRPSTKRPDTVPDVLPEILMMAADTATEAPLLLADGLWIKYRTSLDWAWKVWDNAIASLRQFPVMNPNVAERKACALRYGIFLRQVDQHLPDGLDGDVQRWFSGPGQNEIAALNSEAWDVVTVVLLYLCVHGALKTTTILTGVVYPAWQLGASESGAEVQTFLTAANNLFRQLLLQENPNPSGIPPVDLFDVQCLQTRRRTVYEEPHFSTLVMNIPLLIFLENKPDVPEDIKTELTSLRYRLCHDTQFRQGAYRNLDVIRAAFEDSAYLSETSSAANLGQHTIAGLRTILGENVDEKDMYDWPEVTCLLSPWKIVATTIQMQFSVKQLGKALAQESTHDAASVNLNKLSIMLFHQSMTSEEAYYVGEMAQGADNTVASKFIANGLKCINELLQELKSEQMTSVTDKLRRIGELLRALVYIAQPFRKEGPLVLNLDLAIQDEFVAILHDKLSTIKATLLKASASAQITGSGEDLSTTISQQLVLLVRLLQFDLGFRGAWTPKLKDLSASFINNLFHLALHYGTADHLNPVVYPLLIDTLLYLIDEIPQPAKPLSFDPFRHYPNTPISGLPGDLPLEYRNQVLSLLSTLSTNSAVTNLVNSHIDATGNLVYDQPVVNRPWEWIENLGEPSAIDSSAAKDAAKDEDRDREEKARLKSRYLVKNSGSLSLEYFGARMTGDGVVENIAKEYDTQVQNDIRAFEDGLSAEGILVRDWRESRVDAEQEPSPTSVSSGRAIQSVGGTSGSGDGDLDSGSASGQVKSERRSTPMKASPTPSVVSRSSAKGSVASLKQSPSTRSMLEGVDIEGVASHSAATKRKVDDDDEIEILEGSVPLQAAPPSKRAKASAGKTAGKTAGKTAAKTKAKKR
Length1652
PositionKinase
OrganismLeucoagaricus sp. SymC.cos
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Agaricaceae> Leucoagaricus.
Aromaticity0.08
Grand average of hydropathy-0.262
Instability index42.26
Isoelectric point6.14
Molecular weight185081.82
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06706
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     215.52|      58|      97|     442|     501|       1
---------------------------------------------------------------------------
  248-  279 (35.51/13.11)	..............LKLLRTFYT..............................................EGL..VD.....HRSF....LIW..........FVNQMgACNLA..........
  442-  501 (103.91/54.11)	QNELDNT.PAFKEKLDMLLTWSV..............................................TPLQYGD.....HRPFAAvtLIW..........LWRDR.ACERATRRDIETPND
  504-  601 (31.45/10.93)	QDQL...................fdwldtsesagdakiirdiallygklvkqelfsypkyiqrliargeTGLSFTEsvesrHRQF....LRWiplhnstlseL.NQR.RVTLYGVRARETPED
  620-  655 (44.65/18.02)	GEQDDSTvPNFIALLDRCRTL.V..............................................DSTRFEQ.....TRIFRQ....W...............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.06|      15|      45|    1511|    1525|       2
---------------------------------------------------------------------------
 1511- 1525 (26.62/18.12)	PSPTSVSSGRAIQSV
 1558- 1572 (23.65/15.14)	PTPSVVSRSSAKGSV
 1579- 1593 (23.79/15.28)	PSTRSMLEGVDIEGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     162.07|      44|      93|    1167|    1210|       6
---------------------------------------------------------------------------
 1134- 1159 (30.58/16.23)	................LNKLSIMLFHQSMTS..EEAYYV.GEMAQ
 1161- 1204 (70.30/47.19)	ADNTVASKFIANGLKCINELLQELKSEQMTSVTDKLRRI.GELLR
 1205- 1248 (61.20/40.10)	ALVYIAQPFRKEGPLVLN.LDLAIQDEFVAILHDKLSTIkATLLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.82|      16|      67|     315|     330|       9
---------------------------------------------------------------------------
  315-  330 (27.88/20.89)	EIRETAQEYLFDIEKQ
  384-  399 (27.94/20.96)	EIRRSISDNLYDIQKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.29|      21|     101|    1530|    1550|      10
---------------------------------------------------------------------------
 1464- 1484 (20.60/11.41)	..GDGVVENIAKEydT.QVQNDIR
 1485- 1502 (25.52/16.29)	AFEDG.L...SAE..GiLVRDWRE
 1530- 1550 (36.17/26.84)	GSGDGDLDSGSAS..G.QVKSERR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06706 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) VRDWRESRVDAEQEPSPTSVSSGRAIQSVGGTSGSGDGDLDSGSASGQVKSERRSTPMKASPTPSVVSRSSAKGSVASLKQSPSTRSMLEGVDIEGVASHSAATKRKVDDDDEIEILEGSVPLQAAPPSKRAKASAGKTAGKTAGKTAAKTKAKKR
1497
1652










Molecular Recognition Features






MoRF SequenceStartStop




1) DDEIEILEGSVPLQAAPPSKRAKASAGKTAGKTAGKTAAKTKAKKR
2) KDEKKLPIYES
3) LGYPGFF
1607
5
30
1652
15
36