Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MSQPPPLNAVPGPSSASQDVSSMSSILMGPLNELQALSHTLFLSLSPPQTKPPPPPPLDAFLCCDKTLADAINVAQTHQIKQRKIEGLESEILDLEAQWRNICEELAKGKKELEELIEEGEERLKAIEQAKKASIPYPELLAYAQSLSAFTSAPPNMPDLSLPGQPPPPLFFPPFPNEEKMRRGHLNAEAPLGTLGETHSVGRRATVSPNTDFNQHLGANPYRQDRRAPQPQFFDLDLDLNPDL |
Length | 244 |
Position | Middle |
Organism | Leucoagaricus sp. SymC.cos |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Agaricaceae> Leucoagaricus. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.522 |
Instability index | 73.85 |
Isoelectric point | 4.93 |
Molecular weight | 26806.08 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP06698 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 55.82| 14| 114| 43| 57| 1 --------------------------------------------------------------------------- 43- 57 (28.20/12.58) LSLsPPQTKPP...PPPP 160- 176 (27.62/ 8.71) LSL.PGQPPPPlffPPFP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 57.70| 17| 20| 203| 221| 2 --------------------------------------------------------------------------- 203- 221 (24.24/22.08) RRATvSPNTdFNQHLGANP 226- 242 (33.46/19.65) RRAP.QPQF.FDLDLDLNP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 56.71| 18| 22| 75| 96| 3 --------------------------------------------------------------------------- 75- 92 (30.08/22.95) AQTHQIKQRKIEG...LESEI 97- 117 (26.62/10.86) AQWRNICEELAKGkkeLEELI --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) QFFDLDLDLN 2) YRQDRR | 232 222 | 241 227 |
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