<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06696

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMNTAGLLAAAISLAPDTAVAVHSLVPDTGSISPPDVLHSARRHLVSSRQIQDALLPSVQLGHRPALYVFSIVPAVRMQATVSAMDALRFDGLVAPSTASYFPFQKIYEQPRHILSHFLSAVRTRLIDNIVSSGSGVQRCKDGFLISHQQLTPETDWGAGWEYKALSRPLIFCHIQLQPTSSAILIRPTLLPTPYLPLPSCLPLLPRSPILLLPYGTPAYFLTTYSGPTSVLVRQFTDALQGHGQPPLDSSFIIGWISVENRRGEDKGITFIYPTRLCLAFVPALNRSLLDYTPDLPGPLQPSPKLLSASTPLSECPPITYPYRPSLLGSPTTELKAFRTLTLSKSKNIRTVAAQVSSYVDHVAKDRERERERLKREREGGTAHSPSLLARTTPSTSSNPQNAAPPPPLAVHTPTPTTTAAMPTQNFYPSPPQADTTAVPIPGNTSPVLPVAPQPPVTQTPAPSTTQVQAPPLTASSSSSYDPFGYLGMNMVDMDMDFGMDMGMNFGMGMGMNLGGNSGTTSAGPANRSTYSDGASREMGLGGSSGMDFEDFTDDDFNFFDQPSTHAPAPPPPPPPPQHQPTTSGISAIPNSLQVTSPPLFGDVHLSGPGPPHPTPHSQPTPASHGGPWSSNFPEGFTPRSVEHMDSVIPPELATASPSATPLINNNNVDGACPLTPNVHLDPHPHSLQPPPDITVLDDSRKIFNFDPIPFSKYHRVCDGKYAPAGKFGLPIVNYNKKPAENTTGTTSWKPRYDAITDPRVGVMRKLIGVKRKLTVQGGRTGKDVRTSPWTTEHEEWKVHRSAGDPKDIDSEPSEDEMSQSEDGVSEEEETPATSRPSTPPPSYLPLGPTLIHTQFHHTYLLPLSKPLRPPGSSISGPGAHGGLAVTPMPIANVPTPVSPAAGLGLTAEKWRALEVVINVLAKEAVENVVWRDTWTTSNAFGLSNKALVTEGKKLTEIWVSDIKFVERVFGNLEGVQTGLTVNDVFGLDSPAIPSTRSQALQVLTSPKVSVGKGEAIVTVLPPALRFWEKLGLGPKNGEKDGTVYVLFADDGEQRRAAEVANWLTGVCTVYETKHLGKLSPGTSTYCVKDGLVPLRFDLSFRKLFATFATGLSTVSTPIVLFLVVPITFMSLSSSVFRQILSTMQKALKTLPENRVIVQLIPEHTINHIESDPASTNQLESFCINLYNRILVPVAQPLARIFSPDNTPIPVKSYLQKPIFTLARPIYNKVTYTRSVHASLDVLDRYTLLHVGYRVSSCGKWVMAACVDQRGEAWDQAVWLVKTDQQDSDGEASAGGSHEESFAAKKVWEFVTGFAKRADVEWRIVISKLGIMDEAELTAWTTFLSTVIPTSGPGSVHVSLICADPDSSWLFTKLSPDLPHHQPGTNTSKSPPPKHSIFSDASSMTYALFPTTVLPIATPPTQSDLGLIPHPVGLVPRSTTCLVRVPRSAPLTSISMLHIHVLSTRCSPPLLAKKTSAVELKTIHADVTKNFYELSVLAHSRWKISAPEPGSSTGSTSSSNLGLGIGSRTGVNPILPIHLAMVDIMGQVTDGADGVEIDS
Length1558
PositionKinase
OrganismLeucoagaricus sp. SymC.cos
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Agaricaceae> Leucoagaricus.
Aromaticity0.07
Grand average of hydropathy-0.186
Instability index46.93
Isoelectric point6.60
Molecular weight168023.25
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06696
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     324.71|      40|      40|     565|     604|       1
---------------------------------------------------------------------------
  399-  437 (51.39/15.23)	...PQNAAPPP..PlAVHT.P...TPTT...................TAAMPTQNFYPS..P...P...Q..........ADTTA
  444-  487 (39.37/ 9.96)	T.SPVLPVAPQ..P.PVTQtP............................A.PSTTQVQA..P...P...LtasssssydpFGYLG
  565-  604 (79.72/27.66)	H.APAPPPPPP..P.PQHQ.P...TTSG...................ISAIPNSLQVTS..P...P...L..........FGDVH
  606-  667 (48.58/14.00)	S.GPGPPHPTP..H.SQPT.P...ASHGgpwssnfpegftprsvehmDSVIPPELATAS..PsatP...L..........INNNN
  679-  714 (39.02/ 9.81)	HlDPHPHSLQP..P.PD..............................ITVLDDSRKIFNfdP...I...P..........FSKYH
  721-  758 (33.25/ 7.28)	Y.APAGKFGLPivN.YNKK.PaenTTGT...................TSWKPRYDAITD..P.......................
 1375- 1401 (33.39/ 7.34)	...PDLPH.........HQ.P...GTN....................TSKSP.........P...PkhsI..........FSDAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     366.13|      89|     259|      26|     114|       2
---------------------------------------------------------------------------
   26-  103 (118.36/57.38)	......................PD.TGSISPPDVLHSARRHLVSS...................RQIQDALLPSVQLG...H.RPALYV...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FSIVPAVRMQATVSAM....DALRFDGLVAP...S..TASYFPF
  104-  206 (124.86/60.98)	QKIYEQPRHILshflsavrtrlID.NIVSSGSGVQRCKDGFLISH...................QQ....LTPETDWGagwE.YKALSR...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PLIFCHIQLQPTSSAIlirpTLLPTPYLPLP...S..CLPLLPR
  207-  282 (65.87/28.28)	SPILLLP......................................ygtpayflttysgptsvlvRQFTDAL....Q.G...HgQPPLDS...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SFIIGWISVENRRGED....KGITF...IYP...TrlCLAFVP.
  283-  325 (29.82/ 8.29)	....ALNRSLL........dytPDlPGPLQPSPKLLSASTPLSEC...................PPITYPYRPS......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1409- 1446 (27.22/ 6.85)	.........................................................................................llgspttelkafrtltlsksknirtvaaqvssyvdhvakdrerererlkrereggtahspsllarttpstssnpqnaapppplavhtptptttaamptqnfypsppqadttavpipgntspvlpvapqppvtqtpapsttqvqappltasssssydpfgylgmnmvdmdmdfgmdmgmnfgmgmgmnlggnsgttsagpanrstysdgasremglggssgmdfedftdddfnffdqpsthapappppppppqhqpttsgisaipnslqvtspplfgdvhlsgpgpphptphsqptpashggpwssnfpegftprsvehmdsvippelataspsatplinnnnvdgacpltpnvhldphphslqpppditvlddsrkifnfdpipfskyhrvcdgkyapagkfglpivnynkkpaenttgttswkprydaitdprvgvmrkligvkrkltvqggrtgkdvrtspwtteheewkvhrsagdpkdidsepsedemsqsedgvseeeetpatsrpstpppsylplgptlihtqfhhtyllplskplrppgssisgpgahgglavtpmpianvptpvspaaglgltaekwralevvinvlakeavenvvwrdtwttsnafglsnkalvtegkklteiwvsdikfvervfgnlegvqtgltvndvfgldspaipstrsqalqvltspkvsvgkgeaivtvlppalrfweklglgpkngekdgtvyvlfaddgeqrraaevanwltgvctvyetkhlgklspgtstycvkdglvplrfdlsfrklfatfatglstvstpivlflvvpitfmslsssvfrqilstmqkalktlpenrvivqlipehtinhiesdpastnqlesfcinlynrilvpvaqplarifspdntpipvksylqkpiftlarpiynkvtytrsvhasldvldrytllhvgyrvsscgkwvmaacvdqrgeawdqavwlvktdqqdsdgeasaggsheesfaakkvwefvtgfakradvewrivisklgimdeaeltawttflstviptsgpgsvhvslicadpdsswlftklspdlphhqpgtntskspppkhsifsdassmtyalfPTTVLPIATPPTQSDL....GLIPHPVGLVPrstT..CLVRVPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.04|      22|     547|     920|     943|       3
---------------------------------------------------------------------------
  920-  943 (34.28/31.17)	LAKE..AVE.NVVWRDtwTTSNAFGLS
 1470- 1494 (28.76/17.35)	LAKKtsAVElKTIHAD..VTKNFYELS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      61.45|      12|     261|     507|     518|       4
---------------------------------------------------------------------------
  493-  502 (15.53/ 7.90)	..MDMDFGMDMG
  507-  518 (24.45/17.53)	MGMGMNLGGNSG
  534-  545 (21.47/14.31)	ASREMGLGGSSG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06696 with Med13 domain of Kingdom Fungi
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