<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06679

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMNNQHTSAWPLPPLYFEEYTDYHMDLIEKSLDSTSEDSSTLEVQHLLPPAYPLNNEFKLFGVERTLENTSISSLKTLSNQNFKEYQKKSKKLKKLNKSLILNYLSLIEILSVNPIQSESCRLEIKECLTNMLDLVNEFRPIQALEHFKVLLNNQLDQTENSINLIKEFESGFNNQINDLIASHTKEELSSEDETLSDEEVELESELEVDTLSEVTYSTKRSLMNTSSQVKLKKSSKIELEKLLNYKNNINTRHLLDNQFNLGVINKLNLI
Length270
PositionMiddle
OrganismConidiobolus coronatus (strain ATCC 28846 / CBS 209.66 / NRRL 28638) (Delacroixia coronata)
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Zoopagomycota> Entomophthoromycotina> Entomophthoromycetes> Entomophthorales> Ancylistaceae> Conidiobolus.
Aromaticity0.07
Grand average of hydropathy-0.553
Instability index39.23
Isoelectric point4.96
Molecular weight31232.90
Publications
PubMed=25977457

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06679
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.10|      33|      34|      11|      44|       1
---------------------------------------------------------------------------
   11-   44 (53.81/40.77)	LPPLYfEEYTDYHMDLIEKSLDSTSEDS.STLEVQ
   47-   80 (53.29/35.02)	LPPAY.PLNNEFKLFGVERTLENTSISSlKTLSNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.01|      17|      18|     141|     157|       2
---------------------------------------------------------------------------
  115-  134 (20.96/ 8.98)	IQSescrLE.IKECLTNMLDL
  141-  157 (29.52/14.92)	IQA....LEHFKVLLNNQLDQ
  162-  178 (25.52/12.14)	INL....IKEFESGFNNQIND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.37|      17|      28|     193|     211|       3
---------------------------------------------------------------------------
  193-  211 (21.51/18.40)	ETLSdeEVELE..SELEVDTL
  224-  242 (21.86/11.58)	NTSS..QVKLKksSKIELEKL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06679 with Med7 domain of Kingdom Fungi
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