<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06678

Description Mediator of RNA polymerase II transcription subunit 8
SequenceMDENRLENKLNVQELQSTKLKIAQIRDSLSEFYNMINFNDQQMANWTDVFTKYNILVAKYLNLTDELTNFNYKKLFLHPDQALSEDLQIRAVGTLLRTKQIPQVEDLQMKNIQSCLSQYKELDDSKLPDNDTRVLGDVLARWQQRIKRLNARVEKVLAIFEEARETSQYKRRPEKRPLPSKDSDTSAPTTPTNVEENKDAEQQPPPVKKPNIAVSAPKTLDQMMRWLSQGVKE
Length233
PositionHead
OrganismConidiobolus coronatus (strain ATCC 28846 / CBS 209.66 / NRRL 28638) (Delacroixia coronata)
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Zoopagomycota> Entomophthoromycotina> Entomophthoromycetes> Entomophthorales> Ancylistaceae> Conidiobolus.
Aromaticity0.06
Grand average of hydropathy-0.830
Instability index58.92
Isoelectric point7.72
Molecular weight27137.53
Publications
PubMed=25977457

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364144
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP06678
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.36|      15|      48|     117|     131|       1
---------------------------------------------------------------------------
  117-  131 (27.62/17.22)	SQYKELDDSK.LPDND
  167-  182 (23.74/13.89)	SQYKRRPEKRpLPSKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      64.15|      15|      18|      42|      56|       2
---------------------------------------------------------------------------
   21-   36 (19.60/11.27)	KIAQIRDSLSEfYNMI
   42-   56 (27.44/18.15)	QMANWTDVFTK.YNIL
   59-   71 (17.11/ 9.08)	KYLNLTDELTN.FN..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.76|      12|      18|      85|      96|       3
---------------------------------------------------------------------------
   85-   96 (19.66/11.67)	EDLQIRAVGTLL
  105-  116 (22.09/13.80)	EDLQMKNIQSCL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06678 with Med8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) TSQYKRRPEKRPLPSKDSDTSAPTTPTNVEENKDAEQQPPPVKKPNIAVSAPKTLDQMMRWLSQGVK
166
232










Molecular Recognition Features






MoRF SequenceStartStop




1) KKPNIAVSAPKTLDQMMRWLSQGV
208
231