<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06677

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMVKNLMIKTEEGGEGDNLNPSNLQSSSQLLSKSNLNDPESEKEEGESLNTNDTKISAKSSIEKLLPNLDLIKKPVNTSFPWVHYGNGLFEDDLSLQVFIDQIIFIPNYTKSSAISTEVMGQDNYSKILGFAKVLRKVCNSIELEAKSEETGNNNEGEVKEEDKKLLISSFLPLKQYTNLKEKSYKEDNPILILYKEPNLRLGYKSNWIGVKPSSIQFWDRLDLVPMNNSKQIQYCCLIPQNRDLLLECNNFFNNLKYNFHKEVLDGYLQISRPIAGNGMSQGYNQGGQAQPGGQGQAADMTGGRVNQHQEGITTPQTPGLNQSTTPTQSSQPFDKISKEAILDTYFRHASMLSDELFALNQRDPNQLQQQTPQTIIIFYITYQIPLTYQMLFELSSTLTKSIFKKNNSEANNFKIQLVPLPLEFLLSFRNLEESGKILLNFSLNLYNQVYNLSRGEDDQILKSFQPSYSLVPNLPKKIKFGPDTGEEEFREDKFYCHLSYSLGPNYEYVMVHWSDNVGVNRDFSVIPLPVFNPNKPIPYPLYLHHIWNATQAFVQRSCPWNPDSTNIVYFITKLGKLYKLELEAWRLFWDSTNSLICLFSLLGESQFNCFPNLKDFDHLSVGGIKMSKSGKSMSGSGLNANSNTSNPNIDDFGGEMEEEFGFTGNRNRHLILLPASRYPISPDVIPLLMGVILDLPVVPIGQNQRVRLNTNLTQNFTSPNYCAISDTHLPNSISNQQKTIQLALIYHTKSELQTHEIFKTFLKQTSDLSYLNLDYYLQDPNFQVSKELLKFGEQSNRLGVILDLVGFGCCKLPYNWYLMVKTTIALIEGGVAMGDRYLN
Length839
PositionKinase
OrganismConidiobolus coronatus (strain ATCC 28846 / CBS 209.66 / NRRL 28638) (Delacroixia coronata)
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Zoopagomycota> Entomophthoromycotina> Entomophthoromycetes> Entomophthorales> Ancylistaceae> Conidiobolus.
Aromaticity0.10
Grand average of hydropathy-0.412
Instability index37.08
Isoelectric point5.63
Molecular weight95268.95
Publications
PubMed=25977457

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP06677
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.78|      27|      29|     442|     470|       1
---------------------------------------------------------------------------
  444-  470 (48.09/33.80)	NLYNQV.YNLSRGEDDQILKSF..QPSYSL
  473-  502 (39.69/20.47)	NLPKKIkFGPDTGEEEFREDKFycHLSYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     480.39|     194|     365|     218|     441|       2
---------------------------------------------------------------------------
  218-  291 (68.25/38.46)	....................................................................................................................................................................................................................................................................................................................WDRLDLVPMNNSKQIQY.CCLIPQNRdLLLECN.NFFNNLKyNF.HKEVldGYLQISRPIA....GNGMS.QGYN.QGGQAQP
  292-  441 (144.13/126.98)	GGQGQAA.DMTGGRvNQHQegITTPQT..PgLNQSTTPTQSSQPFD....KI..SKEAILDTYFRHaSMLSDELFALNQRD.PNQL..QQQtpqtiiifyiTYQIPLTYQMLFELSstlTKSIFK...KNNSEANNfkiqlvpLPLEFLLSFRNLEESgKILLNF..................................................................................................................................................................................................................................
  585-  647 (37.84/ 8.45)	.....................................................................................................................................................................slnlynqvynlsrgeddqilksfqpsyslvpnlpkkikfgpdtgeeefredkfychlsyslgpnyeyvmvhwsdnvgvnrdfsviplpvfnpnkpipyplylhhiwnatqafvqrscpwnpdstnivyfitklgklykleleaW.RL.FWDSTNS....L.ICLFS....LLGESQfNCFPNLK.DFdHLSV..GGIKMSK..S....GKSMSgSGLNaNSNTSNP
  653-  837 (230.17/125.09)	GGEMEEEfGFTGNR.NRHL..ILLPASryP.ISPDVIPLLMGVILDlpvvPIgqNQRVRLNTNLTQ.NFTSPNYCAISDTHlPNSIsnQQK..........TIQLALIYHTKSELQ...THEIFKtflKQTSDLSY.......LNLDYYLQDPNFQVS.KELLKF............................................................................................................................................geqSNRLGVI....LDLVGFgCCKLPYNW..........................YLMVKTTIAliegGVAMG.DRY.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.85|      25|      29|       4|      28|       3
---------------------------------------------------------------------------
    4-   28 (42.70/29.86)	NLMIKTEEGGEGDNLNPSNLQSSSQ
   34-   58 (41.16/28.47)	NLNDPESEKEEGESLNTNDTKISAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.28|      28|      29|     140|     167|       4
---------------------------------------------------------------------------
  113-  144 (33.19/18.16)	AISTEvMGQDNYSKILGFAKvlrKVCNSIELE
  145-  172 (45.98/27.95)	AKSEE.TGNNNEGEVKEEDK...KLLISSFLP
  173-  192 (24.11/11.21)	LK..Q.YTNLKEKSYKE.DN...PILI.....
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06677 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KNLMIKTEEGGEGDNLNPSNLQSSSQLLSKSNLNDPESEKEEGESLNTNDT
2) MSQGYNQGGQAQPGGQGQAADMTGGRVNQHQEGITTPQTPGLNQSTTPTQSSQPF
3
279
53
333










Molecular Recognition Features






MoRF SequenceStartStop




NANANA