<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06672

Description Mediator of RNA polymerase II transcription subunit 10
SequenceMAPAGRMGAADHDVIEQQLKETVQSLYQILVQVSAYDQHTSVSSGSNSTSAAPGAAANSTPTPTSQLSSSSSKPSAEVLAQELRTLSASLQAIHATASHPTPERSLPHIPPELVQYVENGRNPDIYTREFVEQVRRGNQLLRGKQVAFGRFRDILAGEMDSAMPELHDDVATVLEATGGRDRWKDTAPGGGGGAGASGANGTGAGASSSFGQGSSGNGGSAATPSGRALSGTPAP
Length235
PositionMiddle
OrganismMicrodochium bolleyi
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Xylariomycetidae> Xylariales> Microdochiaceae> Microdochium.
Aromaticity0.04
Grand average of hydropathy-0.446
Instability index44.48
Isoelectric point5.65
Molecular weight23991.95
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364146

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06672
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.62|      19|      24|     189|     207|       1
---------------------------------------------------------------------------
  189-  207 (35.24/12.92)	G.GGGGAGASGANGTGAGAS
  211-  230 (30.38/10.29)	GqGSSGNGGSAATPSGRALS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.02|      23|      23|      55|      77|       2
---------------------------------------------------------------------------
   43-   67 (34.16/16.36)	SSGSNSTSAapGA..AANSTPTPTSQL
   68-   90 (34.05/16.28)	SSSSSKPSA..EV..LAQELRTLSASL
   91-  106 (18.81/ 6.03)	QA...........ihATASHPTPERSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.94|      14|      26|     117|     130|       3
---------------------------------------------------------------------------
  117-  130 (26.61/21.12)	VENGRNPDIYTREF
  146-  159 (25.33/19.78)	VAFGRFRDILAGEM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06672 with Med10 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GEMDSAMPELHDDVATVLEATGGRDRWKDTAPGGGGGAGASGANGTGAGASSSFGQGSSGNGGSAATPSGRALSGTPAP
2) LQAIHATASHPTPERSLPHIPPELVQYVENGRN
3) QHTSVSSGSNSTSAAPGAAANSTPTPTSQLSSSSSKPSAEVLAQ
157
90
38
235
122
81










Molecular Recognition Features






MoRF SequenceStartStop




1) RDRWKDTA
2) SGANGTGAGASSSFGQGSSGNGGSAATPSGRALSGTPAP
180
197
187
235