<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06668

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMAASPFSLRPWPTGDKKPKNLGEFVARVNAEPGGFRSVTEDKLREDIRALEETDPASPSSDDENDDDEADETKDDDDNTKDAIAARDEFFRNCDHAHQSAMLALDAISLLLSKEMPVQAGTTLSSALRDAVGIGTLGASRLHDSNVTEARTKNDLAVATGWRVMGLNNMVDSVMAAAERLEKEMELEAKYWADVLAVSDSGWAVCSLPQDPHTLGVRFGFSEAAPEYRDQSLAPLRRQDDGTVRLETARVGRGSQRIRAMVERKGVVTAQSHIPMLTPDDAPLPDRVLEARNTAFSQELWYELNREARTLLSYGVQMTDSDVTYQAGPDTKIILTLHDLADDDKDEIPAGSSHEDRELADSITMVLHFLLSFAHRQNYRTRTQPTAASRSNQTTQPYALLRPLIARTRHISTCDGLARFLKGLVSVLRKAGVSTASYTMAAQPVAVQPHQEAQVRRSSKSEILATNLVHSMDLQAELVLTADSRLNIRGRTFMGPWIGQQLRVFLPPPPPPPPGTGDGGGANQAAAPTPGPLESSYPPSGEAYPDLPSLTTYIRNATLRALSHDLAATAAGALAAAGVADISRSEGFSGPVVTSDHGSREVQLTFAAAARDVNGDSSSTSKGSDGHLVLQCEGHWRSSSGTSSSTDTAAESGNGIVAGVKTQRWTWAAAASPPAGNVSTSTSGGDYDQKIKKEPQVNENETPDADDNLSVDKLEDVVIKILGGKL
Length725
PositionHead
OrganismMicrodochium bolleyi
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Xylariomycetidae> Xylariales> Microdochiaceae> Microdochium.
Aromaticity0.05
Grand average of hydropathy-0.455
Instability index40.09
Isoelectric point5.05
Molecular weight77920.63
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364140

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06668
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.30|      31|     163|     511|     541|       1
---------------------------------------------------------------------------
  511-  541 (59.75/29.82)	PPPG...TGDGGGA.NQAAAPTPGPLESSYPPSGE
  672-  706 (46.55/21.75)	PPAGnvsTSTSGGDyDQKIKKEPQVNENETPDADD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     235.34|      77|     268|     278|     358|       2
---------------------------------------------------------------------------
  278-  358 (120.47/86.77)	PDDAPLPDRVLEARNTAFSQELwyeLNREARTLLSYGV.QMTDSD......VTYQAGpDTKIILTLHDLADDDKDEIPAGSSHEDREL
  544-  627 (114.87/69.48)	PDLPSLTTYIRNATLRALSHDL...AATAAGALAAAGVaDISRSEgfsgpvVTSDHG.SREVQLTFAAAARDVNGDSSSTSKGSDGHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.69|      29|      38|     138|     166|       3
---------------------------------------------------------------------------
  138-  166 (51.71/31.75)	ASRLHDSNVTEARTKND.LAVA.TGWRVMGL
  177-  207 (43.98/26.01)	AERLEKEMELEAKYWADvLAVSdSGWAVCSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.36|      26|     226|     411|     441|       5
---------------------------------------------------------------------------
  411-  441 (40.29/36.48)	STCDGLARFLKGLVsvlrkAGVSTASYTMAA
  643-  668 (48.08/31.39)	SSTDTAAESGNGIV.....AGVKTQRWTWAA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06668 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LRVFLPPPPPPPPGTGDGGGANQAAAPTPGPLESSYPPSGE
2) MAASPFSLRPWPTGDKKPKNLGEFVARVNAEPGGFRSVTEDKLREDIRALEETDPASPSSDDENDDDEADETKDDDDNTKDAIAARDE
3) SEGFSGPVVTSDHGSREVQLTFAAAARDVNGDSSSTSKGSDGHLVLQCEGHWRSSSGTSSSTDTAAESGNGI
4) WAAAASPPAGNVSTSTSGGDYDQKIKKEPQVNENETPDADDNLSV
501
1
584
666
541
88
655
710










Molecular Recognition Features






MoRF SequenceStartStop




1) AASPFSLRPWPTGDKKPKNLGEFVARVN
2) GFRSVTEDKLREDIRALEE
3) YDQKIKK
2
34
686
29
52
692