<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06667

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMSTGRPPGGGSSAALAPAAPTTQQQRGSSSSTDHSQSLSQWKGFMSRCISSRLDPETFDSYAALLHSKHPLPTVAVADIVFRPHESNSESLDPRIPRYVQVLVQRGLVNTPSILQALWRYSSSQAFAQDQQQHDGRRPLIWRSSYAAEEVIFYRLTKAVGLGSGIKCAADAIQVCQVMARWMTLFTAASAAFAQQELMMGQVHTAAQSEMEAARAAFVMLLLSVCDNPAVLHALAQPYAKEVRKALSASLATFVPSILQTASQIAGRLEHFRTETLASFDPVEKDNTKDVVKSDMDELLDSTIGLESFVVPDLQITNSRAGLYVYLNAALVGRPLLDDHTFLSFLHNRYQGDIQATAIDLILASFDILANAVFRRESHKTGYLLRSYLINKVPLLLANLATSMFPPLTPQFCISEAMSQVDTNAFPSMSEMFDLSNDNRDSVTENVRADFCFACCLHGLIPEDSINSLIGDMHYQTLPAGGRYIKQTLVAECMADPERIMKLIGEMENYDGNVGAACRAVTEVIGRLCSEKETITLKNICAQLAKKPLSMDVMLLFDKPATFLHPLCELLDNWRYDEDQGEYQPVYEEFGSILLLVLAFAYRYNLTAVDIGIRSPQSFVANLLNKGQWSRGLDELSEQEKGHLGGWIQGLFDNEAGGLGDELMSSCPPQDFYLLVPTLFHNMVLAFSVGYLQEESLKTGMEYLVDTFLLPSLVMAINYMATQLWNDRKDERKAAIRILQLILLTKHGSNDAQAMLSAVLNVVAKPLENALRLYQRQDPQSQEVDPLLNAIKENIRLSRRTAGAGHNDMESWTSTSGGGLAAAVRHTIQGLVQWGMQPGLNVMPTNYTHRQMLAAARMLGARRLLGIILDEVKQHTESPASTSLSLRAALRAEAEDFKTTQKTDPLLADITVRLHRRVEAQLHGFDGLDGLGDGSGDLSGLGGLGGNGTGSDGGGGGMDLGGADDDIFSGLEGVGSSADLLQGWDGMDFS
Length989
PositionTail
OrganismMicrodochium bolleyi
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Xylariomycetidae> Xylariales> Microdochiaceae> Microdochium.
Aromaticity0.07
Grand average of hydropathy-0.102
Instability index48.32
Isoelectric point5.18
Molecular weight108150.75
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364142

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06667
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.28|      20|      26|     940|     959|       1
---------------------------------------------------------------------------
  921-  937 (27.01/13.64)	LHGFDGlDGLG.D..GSG...DL
  940-  959 (40.60/24.79)	LGGLGG.NGTGSD..GGGGGMDL
  967-  988 (33.67/19.10)	FSGLEG.VGSSADllQGWDGMDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.40|      18|      22|     490|     507|       2
---------------------------------------------------------------------------
  490-  507 (33.64/21.97)	AECMADPERIMKLIGEME
  515-  532 (31.76/20.36)	AACRAVTEVIGRLCSEKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.78|      20|      21|     396|     415|       3
---------------------------------------------------------------------------
  396-  415 (36.21/24.01)	LANLATSMFPPLTPQFCISE
  417-  436 (35.57/23.44)	MSQVDTNAFPSMSEMFDLSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.97|      24|      25|     231|     255|       4
---------------------------------------------------------------------------
  231-  255 (33.70/30.86)	LHALAQpYAKEVRKALSASLATFVP
  258-  281 (40.27/30.42)	LQTASQ.IAGRLEHFRTETLASFDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.60|      11|      21|     765|     775|       5
---------------------------------------------------------------------------
  765-  775 (21.05/13.75)	PLENA....LRLYQR
  785-  799 (14.55/ 7.13)	PLLNAikenIRLSRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.21|      22|      26|     631|     653|       8
---------------------------------------------------------------------------
  631-  653 (37.06/32.19)	GlDEL.SEQEKGHLGGWIQGLFDN
  659-  681 (38.15/27.57)	G.DELmSSCPPQDFYLLVPTLFHN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      28.48|      10|      21|     361|     372|      10
---------------------------------------------------------------------------
  361-  372 (11.47/11.30)	ILASFdiLANAV
  383-  392 (17.01/ 8.73)	LLRSY..LINKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.35|      37|     125|     703|     742|      13
---------------------------------------------------------------------------
  703-  742 (59.27/44.12)	LVDTFLLPSL.VMAINYMATQLWNDrkdERK.AAIRILQLIL
  830-  868 (60.09/36.91)	LVQWGMQPGLnVMPTNYTHRQMLAA...ARMlGARRLLGIIL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06667 with Med5 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSTGRPPGGGSSAALAPAAPTTQQQRGSSSSTDHSQ
1
36










Molecular Recognition Features






MoRF SequenceStartStop




1) AALAPAAPT
2) QGWDGMDF
13
981
21
988