<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06663

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMTANEMPLILDNAMDEAAMQVDLDDVDDLFGDGVPLALPPHPPSKRLLQRLDELRRSGCCQGVAWSKTGTIASIAQGGQSLELRYISADPKTAQWTLSDSTHFTPSTSFPGGPIVHLTWSPTNNSSELAVIDSVGRTSIFNFGTNLNRPVRVRGWDTDPVDDLHAVVGTYWLNLLPTHQSKVHPLYSPAVKVGDRYNYEPSFVPISGPFHPNPARSALITVTTRGLLKMFWYQANGKLEETKIDLESVTSADDLITHASICSDLKRVVLFVSLMTQSRQLRVVQVSILWDGTKSENQQANLPPTRPLKPVLVVKHLAVSTWLTGEHDSHLDAAMPKVSLIEFLPTSPNQATKKMASPVIIAVRSFVPTLSSPYNQEMHSSIDVWELQADSQQAVHPAFEKLGTRKSSVGQPPLDLMCLRKLDPIIVDKVVISITQVSFGKAICFTYSDGSVEYRDRFSLQPMYNEVNLDRITSLLEVGFTQEGEAGCLQSALSPTGLSFIQMNEAGKLSWHNLRYGQDVTVPLTGGQLSSVIAALTMVTAQSSFAHINIDDILAIARTFKEQPGFAAQWMTEMVKLLKIVVDYAEEVPHDHLFRNNQLQLLFSILNHIGWNGTSQTRDFRSKLSTVALNLRNIVILITIANNNTHSRQGPTPMDDPEVVSALAGCCKWSTDLLSWLCDSLFCLLDDTDFMGILQKSPPQFSELTAYLHKKNDVALHMIMCSSIRGLLNAVCRRINLLDNLSVLALKYYESRVGKDEPAATPGAPTGAKGGSYGSPLHLAYQRIQRHTSSAMIKISDFDALLTAFGTSIRAIYKVSVEQLNKQQQQNNGANGNNNKDDPGPRARAHCELALLLGGAPPPSFQQPLAKLFMQDLPKLRDQTDPANLFFADYSLLEIDDEDPRALERRRAQGVHVDMFKRIEIVKGESGGTDNNSKNGNDGAGGEGGQPTQWRMCVRCASVMEDFGLTHNRQNLAFVLSQQRNCSCGGRMVLLPLNDKGRGGQ
Length1000
PositionTail
OrganismMicrodochium bolleyi
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Xylariomycetidae> Xylariales> Microdochiaceae> Microdochium.
Aromaticity0.07
Grand average of hydropathy-0.216
Instability index41.37
Isoelectric point6.24
Molecular weight110173.26
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06663
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     203.26|      62|      92|      99|     165|       1
---------------------------------------------------------------------------
   99-  165 (102.19/94.74)	DSTHFTPSTSFPGGPIvHltwsPTNNSSELAVIDSVGRTSIFNFGTNLN.RPVRVRGWDTDPVDDL..HA
  194-  258 (101.06/76.68)	DRYNYEPSFVPISGPF.H....PNPARSALITVTTRGLLKMFWYQANGKlEETKIDLESVTSADDLitHA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     223.24|      55|     103|     791|     846|       3
---------------------------------------------------------------------------
  717-  757 (56.71/29.95)	MIMCSSIR..GL..LNAVCRRINLLDNLSVLAL.KYYESRVG......KDEP.........
  791-  845 (93.27/56.06)	MIKISDFD..AL..LTAFGTSIRAIYKVSVEQLNKQQQQNNGANGNNNKDDPG..PRARAH
  891-  951 (73.26/32.02)	LLEIDDEDprALerRRAQGVHVDMFKRIEIVKGESGGTDNNSKNGNDGAGGEGgqPTQWRM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.21|      41|     466|     487|     527|       7
---------------------------------------------------------------------------
  487-  527 (76.25/52.00)	CLQ..SALSPTGLSFIQMNEAGKLSWH.NLR.YGQDVTVPLT....GGQ
  952- 1000 (56.96/36.88)	CVRcaSVMEDFGLTHNRQNLAFVLSQQrNCScGGRMVLLPLNdkgrGGQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06663 with Med16 domain of Kingdom Fungi
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