<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06652

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMASGGSMPFSSLHPVPTGDRKPKSLGEFIARVQAERGFRNVTEESLKEEVENKKNDVGEVKEEDTVMADGEDESEEPLDAGAARMEVLRNIDTAQNAALMTLDFISLLLSKESPAQAGVTLSQQLRDWTGIGTLGIAKREDNEEQKQRDAEKAKDNRDVSLGWALLDIEKTKESADKAATHLSKEVEREAKYWGEVLSVHQAGWSMCRLPAERHTLGVRFGFSEGRNSSLAPLRRGDDGSALLQHGRVGSGCQRLAITVSRSGEASGRLAVGTSVPDSALLPDRVLEARNTIFAQELWHELHREAHSLASYGVRADNNSINFHPSSGPSLTLELETLEDSAATVGASPDNVLAEATHLGLHILLSHAHRLNELQRLRPTPPHQRRNQTQNQYHLLRPIIAKILYDRSIEQVTSFAGDLTRVLRQGGVHAAAFTLNTPPFPTAELKNTSGGASNRPNASQALTNMLTSSADFQIELTLTPTSRLQIRGRTFLNPLTTTQFQLQLLPNAAAAVSGSEPSNGEQPPAPPPNTLQSSYPPSRDPYPDINSVQLYITNAAAHALTDYAMSLIPPPQQPSNPSTPPAEPAPAEWVKSVRGTAIRDIDTETREIRFDILNSGPENRLTLQIGAAWRVGDKSRLMRWSWAADGDSSSSSTQPPVNDIVAAVVQSRDV
Length669
PositionHead
OrganismColletotrichum salicis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum acutatum species complex.
Aromaticity0.05
Grand average of hydropathy-0.513
Instability index48.03
Isoelectric point5.61
Molecular weight72829.33
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06652
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     409.63|      98|     134|     437|     539|       1
---------------------------------------------------------------------------
  328-  397 (99.10/55.13)	...PslTLELETLEDSAAT.VGASP..DNVLAEATHLGLHILLSHAHRLN...............ELQRL..........RPT....PPHQRRNQTQNQYHLLRP
  437-  539 (157.46/104.77)	PPFP..TAELKNTSGGASNRPNASQALTNMLTSSADFQIELTLTPTSRLQIRgrtfLNPLTTTQFQLQLLPNAAAAvSGSEPSNGEQPPAPPPNTLQSSYPPSRD
  576-  668 (153.07/89.47)	PSTP..PAEPAPAEWVKSVRGTAIRDI.DTETREIRFDI.LNSGPENRLTLQ....IGAAWRVGDKSRLMRWSWAA.DGDSSSSSTQPPV...NDIVAAVVQSRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.35|      16|      35|      75|      90|       2
---------------------------------------------------------------------------
   75-   90 (27.27/15.26)	EEPLDAGAARMEVLRN
  112-  127 (27.07/15.09)	ESPAQAGVTLSQQLRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.03|      42|     133|      19|      60|       3
---------------------------------------------------------------------------
   19-   60 (67.66/42.28)	DRKPKSLGEFIARVQAERGFRNVTEESLKEEVENKKNDVGEV
  155-  196 (69.36/43.51)	DNRDVSLGWALLDIEKTKESADKAATHLSKEVEREAKYWGEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.35|      33|     119|     280|     321|       5
---------------------------------------------------------------------------
  281-  321 (44.38/50.90)	LPDRVLEaRNTIFAQELWHELhREAhslasyGVRADNNSIN
  403-  435 (56.97/32.87)	LYDRSIE.QVTSFAGDLTRVL.RQG......GVHAAAFTLN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06652 with Med17 domain of Kingdom Fungi
Unable to open file!