<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06651

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMFVLITGQSRLQSLTTFAQNNISTIVYRVYEPSPEQASSFPSVAADAETELRGLGHIVYYDANRRVLWYFHIPGKDAEPGDDTQSVLDSSVSVAGATLLMVDEGSFEPISLFKGRAQGQQASNTPTSSSSSNSALDLSLRNPQMGNSGPPSSSDPDSKALSAGALDSKGAGSVPIKEAYEQFITAVLSTTSASFCNRVAAIPLNHRTVLIPSKVTRDGQTERAQDTEAAVVGTFRIYLTTTGALVMSLCLSCCEGLLSVNEPSSPSQLALGSQILAAPFGVLANYQGFVGGGLSYPELALGQTPDAQLWRNADARSSQWRETCIKILQSRGLSPTLLQSCPWIALQMLRRKPGESKTEGKMTPLPSAMATVSWPAVLCFRKKSVMLARSNGLGDSVLLAQDETSDFLNEARTWFQLGVDRDEKVTRRKKEREAAASKEASAAAPAHQPNGHSPLGLRRASNAAAAGAMYPTPPDGVQNPLGITPSMDGTTSSPGAPGIPMAVVDVDTTMTDATAHDATTMHGTLHHDSYGDGWHSNEHANEHTNEHSNENGKSRADSFTGGDNEDNLFGDMGPDMFGDTDITDADFNFFDEEGDDLDLSGLPDLSMPDGPSMPAVLPVSMPEPAKLMMPPVEDTKPEPSPPVFTKPELKHARSTLMDEGKQRSNTDRAGGIKRESSPFDPDIVYKRVRASLADIRSVPSATPARKGSIFDSVDFDPVLPLVNKKYEQGGRFDCKPTLQGLPQETNNQSLHQGPPTTDYLRRHGKGRKPLKQPEHTNALIRTITGNLENSSLIASPGKGDDLASDADDISLVSDQDDSSTSEDEPTSPFKSSIRRLNLDDDVVSHVTSLRDIESVEDSDPTLALDLPKLAKAEASEMLITRYFEDAESLPIHLSLPDEDTITIAQIVTEQAVTGNLRIRDAHANTLHTAIIPETRRQLSSLGRTALQALREVIPICLGEFNTCNFKGVVEIPDVPLLGPPNRFHPRPVNPRDNNAEPPKPNNLFQIPAPHMELRRAEARLSVLPASVQFWESLGLGPAQGTKDVNVVCVFPHWDGMSDVAAAFLDRMRNVYELLKLGSFERLATSSKVTDGLLPYEVDKIATSPGTVSPHIVAGLGDRMEALNQGLISANASEKNYVIYFVYPPDHPGSIVEACTAFQQLFEMHKRTLTDRRQTPVNELVLQLVPLDFLTSSTGIVEPTPSDAIKLAIETYDRCTLFGGPMPSPAIMLEQSLPRGIDFKLSNPSSSSLMHENTCIHIAYAQSIDERWITAAWTDNRGCQQMTASYNLGRKGKALSTSLNDVCHEIWETTHDLISKWKVHWRVIISKCGFMDAQEIGFWQGLAQTESVATVSLTLISVDTNPSMQLVPPAIKVPATTSSAFYTTPVSTPQASIVSPEQSGTPVTPMRENTTSAATPGGTPGDGNADPAEGDAILLDVTDQTWGAVLAHRLSNSSSLGELNPALISGYLVKRGGTKLEDPPVVLEVNIVHADNNPRMYEPLMREMLTYFRGLGTLARARGIVDRGTDIRPWHIAAAEKGVRALYLLM
Length1544
PositionKinase
OrganismColletotrichum salicis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum acutatum species complex.
Aromaticity0.06
Grand average of hydropathy-0.330
Instability index45.88
Isoelectric point5.13
Molecular weight167061.94
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06651
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.80|      15|      34|     635|     652|       1
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  635-  652 (20.96/18.57)	KPEPSPpvFtKPEL..KHAR
  672-  688 (23.84/ 9.80)	KRESSP..F.DPDIvyKRVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     271.31|      84|     845|     488|     631|       2
---------------------------------------------------------------------------
  519-  610 (136.53/142.91)	TMHGtLHHDSYGDGWHSNEHANEHTNEHSN........ENGKSRADSFTGGDNEDNLFGDMGPdmfGDTDITDADFNFFDEEGDDLDLSglPDlsMPDGP
  736-  827 (134.78/51.82)	TLQG.LPQETNNQSLHQGPPTTDYLRRHGKgrkplkqpEHTNALIRTITGNLENSSLIASPGK...GDDLASDADDISLVSDQDDSSTS..ED..EPTSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     185.42|      60|     845|     141|     409|       3
---------------------------------------------------------------------------
   64-  129 (86.69/67.19)	RRVLwyfhIPGKDAEPGdDTQSVLDSSVSVAGA.TLLMVDEGSFePISLFKGRAQGQQASNTPTSSS
  206-  266 (98.73/267.08)	RTVL....IPSKVTRDG.QTERAQDTEAAVVGTfRIYLTTTGAL.VMSLCLSCCEGLLSVNEPSSPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.68|      13|     845|     141|     156|       4
---------------------------------------------------------------------------
  141-  156 (22.70/18.12)	NPQMGNSGPPSssdPD
  988- 1000 (26.98/13.09)	NPRDNNAEPPK...PN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     288.15|     113|     497|     856|     979|       5
---------------------------------------------------------------------------
  861-  898 (15.87/11.96)	.....................................................................................LALDL......PKLAKAEASEMLitRYFEDAESLPIHLSLPDED
  899-  979 (104.20/66.92)	TITIAQIVTEQAVTGNLRIRDAHANTLH.TAIIPETRRQlsSLGrtALQALREVIPICLGEFNTCNFKG.VVEIPDVPLLGPP..............................................
 1400- 1522 (168.08/99.15)	PVTPMRENTTSAATPGGTPGDGNADPAEgDAILLDVTDQ..TWG..AVLAHRLSNSSSLGELNPALISGyLVKRGGTKLEDPPvvLEVNIvhadnnPRMYEPLMREML..TYFRGLGTLARARGIVDRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.42|      39|     555|     448|     488|      11
---------------------------------------------------------------------------
  448-  488 (68.92/37.59)	PNGHspLGLRRA....SNAAAAGAMYPT....PPDGVQ..NPLGITPSMDG
 1006- 1054 (60.50/27.61)	PAPH..MELRRAearlSVLPASVQFWESlglgPAQGTKdvNVVCVFPHWDG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06651 with Med13 domain of Kingdom Fungi
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