<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06648

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMENGGLNGTHPNHDRNLKVNGANGRTMEGQPNKGKAPADTPGTGNTANGLSWGNVQNDSQGKQQSQMSTGLTLQQKPRMNDLPEEIVHITQGYIPLSTIVARLAQHTHEELQKTVIEMGSIKWAPPAVNGNTPHGSDAPDDMSEGNKRKKMLMIKFAQDAHSKWVKALVITDWSKNAEAVSKLIDIKAHIDSKRMLYDFSQDLLIGLKRSLDNARLPNPDLKTALQVLTTGEASWIPEPGYIPPPPLTAEEQLKWIDDLNTMLSLRLNLEDYDKIPHQFKNYSIQSGRVTFVVKGEFEVDLTIADEDFTKQFWFIDFRFAFSPSSSKLSDALVSFLEGHVNEILGKEGLEGCYRFLHEFVLTHKISELRRQAMELSRSTWTGTLMVEPLNRALALQYWNNRYGANGPKSWVMIAVNSAKKTNGQTDSKHSSRLVARWYRDNKEVKDVFLPFDVDNLCAEDLLKTAVARHVEHILSSIHTKLLSYPRFVNRESSMTLTISRTEPMESSLSMQLGSRDNVTLIIQPITGLAAIKPHAKYTLQGENRLNYGGKDPAEDGVTCLENIRWGYFIEECSRRGRSVGWKTCKSPLGGEDIKQIIRTREAFQTIFLQRQSLDQSWFVMVSLSLSGDEWWLLDIDRNTPARPIKFHTKMTLTRGQPDLDDAFWSHLTLFVTGIIQQATDLEHLHRNKIQYLTKESTNYALPQQVRLPSLVIKLSQILGSSETGAQDGSKDVSRQSGKQDSSWAQDQVEVKFKGLQTRPAAAQSQDGNGPSAVEILENAELNTVVDAIVRVKDKGKFSLLRGRIDRNVSFSPKKGEFVFRIRHLVGQPILETLTTHVKSIDRLVGFLEAMSKARGSVKCERVSLQQVIFTYSDITMPGESDQTQKPKRWRVSLDLAKSQIRMSLEKGNPHARVLDLLTSLVNTQDGLRVLIFYMPVLLPVLRTLESIESKWEPLETTNQGRVEIFTRSIDWIALRYTLPSPTGEPRILVLEVRSRMRRNEMWWDFTRATQGPVAPDEEFNKILKGIWESHGDGWRGLRTSAASRPGPSTMELLTKLDDLVRAYAATGDVGNAPSTEGQPTQTSQTISTNQSFGTQPTSVSQGSNRTSGGSKQAPLVLD
Length1118
PositionTail
OrganismColletotrichum salicis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum acutatum species complex.
Aromaticity0.07
Grand average of hydropathy-0.477
Instability index43.38
Isoelectric point8.69
Molecular weight125471.96
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06648
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     602.75|     151|     151|     604|     754|       1
---------------------------------------------------------------------------
  427-  584 (163.48/118.73)	SKHSSRLVARWYRDNKEVK.....................dVFLPFDVDNLCAEDLLKTAVARHVEhilssIHTKllsyprfvnressMTLTisRTEP.MESSLSMQLGSrdNVTLI...IQPITGLAAI..KPHAKYTLQG..ENrLNYGgkDPAEDGVTCLeNIRWGYfIEECSRRGRSVGWKTC
  585-  732 (237.07/176.29)	KSPLGGEDIK....QIIRTREAfQTIFLQRQSLDQSWFVM.VSLSLSGDEWWLLDIDRNTPARPIK.....FHTK.............MTLT..RGQPDLDDAFWSHLTL..FVTGI...IQQATDLEHL..HRNKIQYLTK..ES.TNYA..LPQQVRLPSL.VIKLSQ.ILGSSETGAQDGSKDV
  733-  882 (202.20/149.01)	SRQSGKQDSSWAQDQVEVKFKGlQTRPAAAQSQDGNGPSA.VEI.LENAE...LNTVVDAIVR.VK.....DKGK.............FSLL..RGRIDRNVSFSPKKGE..FVFRIrhlVGQPI.LETLttHVKSIDRLVGflEA.MSKA...RGSVKCER...VSLQQ.VIFTYSDITMPGESDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.76|      25|      31|     922|     946|       5
---------------------------------------------------------------------------
  922-  946 (43.92/36.47)	NTQDGLRVLIFYMPVLLPVLR.TLES
  955-  980 (39.84/32.24)	ETTNQGRVEIFTRSIDWIALRyTLPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.21|      44|    1046|      23|      67|       6
---------------------------------------------------------------------------
   23-   67 (75.98/47.51)	NGRTMEGQPNKGKAPADTPGT.GNTANGLSWGNvQNDSQGKQQSQM
 1071- 1115 (71.22/40.33)	NAPSTEGQPTQTSQTISTNQSfGTQPTSVSQGS.NRTSGGSKQAPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06648 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AATGDVGNAPSTEGQPTQTSQTISTNQSFGTQPTSVSQGSNRTSGGSKQAPLVLD
2) MENGGLNGTHPNHDRNLKVNGANGRTMEGQPNKGKAPADTPGTGNTANGLSWGNVQNDSQGKQQSQMSTGLTLQQKPRMNDLPEEIV
1064
1
1118
87










Molecular Recognition Features






MoRF SequenceStartStop




NANANA