<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06639

Description Transcription mediator subunit Med12
SequenceMGVQPRPPQQRTLSSSGLSVQRPTQQRTLSAQYLPQSPVRKDNLIDLTGDANDAAVAQNRYGTLPRRGGSRLKLELSNEAMLAQHAVSESPKTLTPSRLMPKNETSNLTDMSSPASAKGQPVDADNPPMPMPKRRPRFVVPPAVKDAPAPVIAIKKDGRPKPYHIETPSIAPRYAPFSKPRADAAPKPGFGGSSSGARDIPDMGHADFFPWNGNHPEDQYTESIIKNGYYDKQPQASVETQSAKAALFPALKHKSGLNLLSNIFIGVLNQRKLNGQISSPSTFKPPPRVTLTDTKREMWLRDLANPSISLRRLSRTIPHGIRGKVLLDHCLNKNVPTERAVWLVKCVGANEIRAFKRKGNGPGPFVLGGEAKWLRDWTVFVEQFVEGVSTAFGDNDWKAKVQYAIRLATHLYAEHLLDRDHYMDWLVSGLENSTQSKLPMWILTTQIYWKDLLRLRRYGRRLVNALLSHLNTIHNDPDRDILTQLSTRLTSLLTPLLSAYSDNFVSPATWFKHRDSLLASIPTENDFAQNAVKWINVRNEQLVASASNSQPANRQILVKHLDTSFMSLYSPDLAAQCWAVSEDKGMIVRTLLEWCTSPHRPGTAKVYITASLLRVWVAAGVDVTTAILEFLSASPPTDTRSKKVFHQLVSEIVRSGDFQLQGYIFWLIARGGLRQPADIEAEGSCATRLLVDLPLHALNSSAQATRASLLRRASYDVSDEAEDINTALKCIQHVMGLPLPPGDPMLQRKPVPVGKLCRLISNSNRALQTEVGARLLQIFTKEIIMTKNGPQISPAMFNFARAALEAASDYSVLVEIVKVVSRASNPEILASCADTFNVHLPIFAALGVAKELFDALMERLKAVSDEQGPAARPLLASLANLSTLIPGYTNTAVYLRQQLHQCDRNNPIDACSPVSDNMTAQLQDAEGELHEEIEKLLTSGTSIDRPTMDRLFQTVVGRLESCWLKSPDRQRAYSALLGRLRIFDAQHFDVRMTDWVHHISALKTRPGLENIYPLLISMGCLTLPIILTTTSVEAGRIAMNPSMPPNNTTTYMQEVLSLTTMPLPAKTALTPEETYRFYIQQRVAPRQNHKDMVYLVRNALVEFSRLQGVVEFSMLPLASPEIKDTALQLLKFLVLRDPPSVVQALGIKNPEPALTSLFAQITTKLLLPDAGDDSPLTFETVLELANEFTLPFCQLKLSVGLAADSTTSPGGGEQALTQFDMFSRAMDRAVSANNVMWTSMLPYLSEDITEHLKKQAHLRFLGLFPSKKNPPAADPLSQESTQLAGSLLSVVEAILRGRPPVRTSQLTSGMVEKLAELWELLATDDINKRDLRASILRYWLPALLRFITLHTTANEPVPAATQPQAANNMKPPANAAAFEIRARILIVLSGLTLELDNLAFQDAQNGRPLGQQVFDLALLLVDTLPDDIRLQCVRVLLTGGTMQNPASSDARLRYLFSHMPPPTEQFVLAHRQQSTTQPNGPQRIKMPISMQGTDKLTPFIYRKWEMLSEPTPNVGENDTALSLTLFEAIKIQ
Length1532
PositionKinase
OrganismColletotrichum salicis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum acutatum species complex.
Aromaticity0.07
Grand average of hydropathy-0.221
Instability index46.03
Isoelectric point8.97
Molecular weight169748.08
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06639
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     186.10|      82|     128|    1050|    1177|       1
---------------------------------------------------------------------------
 1050- 1112 (39.75/39.90)	...................................................................................TYMQEVLSL......TTMPLPAKTALTPEETYRFYIQQRVAPRQnhkdmvylvrnalvefsrlqgVVEF
 1113- 1238 (99.66/94.50)	SMLPLASPEI.....KDTAlqlLKFLVLRdpPSvvqalgIKNPePALTSLfAQITTKLllpdagddspltfetvlelaneftlPFCQLKLSVglaadsTTSPGGGEQALTQFDMFSRAMDRAVSANN.....................VMWT
 1239- 1283 (46.69/11.88)	SMLPYLSEDItehlkKQAH...LRFLGLF..PS......KKNP.PAADPL.SQESTQL..............................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.70|      25|      42|     802|     826|       2
---------------------------------------------------------------------------
  802-  826 (40.08/26.63)	AALEAASD.YSVLVEIVKVVSRASNP
  844-  869 (37.62/24.56)	AALGVAKElFDALMERLKAVSDEQGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.04|      17|      43|     118|     137|       3
---------------------------------------------------------------------------
  121-  137 (35.24/22.81)	PVDADNP...PMPMPKRRPR
  162-  181 (26.80/ 8.12)	PYHIETPsiaPRYAPFSKPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.44|      25|      43|     294|     327|       4
---------------------------------------------------------------------------
  304-  345 (18.25/32.28)	ANPsisLRRLSRTiPHGiRGKVLLdhclnknvpTEravWLVK
  349-  376 (42.18/20.80)	ANE...IRAFKRK.GNG.PGPFVL......ggeAK...WLRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.07|      17|      43|     678|     695|       5
---------------------------------------------------------------------------
  678-  695 (24.98/23.22)	DIEAEGSCATRLLvDLPL
  723-  739 (31.08/23.41)	DINTALKCIQHVM.GLPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     184.50|      48|     129|     490|     538|       6
---------------------------------------------------------------------------
  490-  538 (79.74/64.02)	TSLLTPLLSAYSDNfVSPAT...WFKHR...DSLLASIPTENDFA.QN.AV...KWINVR
  542-  589 (44.36/28.39)	.......LVASASN.SQPANrqiLVKHL...DTSFMSLYSPDLAA.QCwAVsedKGMIVR
  624-  670 (60.40/41.96)	TTAILEFLSA......SPPT...DTRSKkvfHQLVSEIVRSGDFQlQG.YI...FWLIAR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06639 with Med12 domain of Kingdom Fungi
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