<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06634
Description |
Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MENSRACRIDRITHSALLCLWLPIANLLTIQGLPWPMNRELQACTIFHILGVKARHSDSPAMNQASQTWPTPKHRTDTTHKEQSSRKGTKAPLGGALGPGVGVEWTGVPGKGCWEPIIPFPFTPGPILPLRGPGLGAPPGADMINAYDDNFETAQIAMKDGNRTELLQRVESPVVGLVNMGENVPPQELPTFTSADRIRQLNDMDKDVTKLLHSAGLAIQALTNAKPDSSSVAPDGSLDSHKTRFKEASAKYFALLSSADVNLRRQIYSLEESSLVGPEKGPRAGDTKTGARAEGVVGAKSRVPNSLDISRLNTRKDTVGKDKEAELWAAARKFVEQTQKPSEASKDSRPSNEPEGMQMD |
Length | 360 |
Position | Head |
Organism | Penicillium patulum (Penicillium griseofulvum) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.526 |
Instability index | 43.27 |
Isoelectric point | 8.27 |
Molecular weight | 39024.78 |
Publications | PubMed=26729047
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147
|
GO - Cellular Component | integral component of membrane GO:0016021 IEA:UniProtKB-KW
mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP06634
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 58.50| 16| 33| 89| 110| 1
---------------------------------------------------------------------------
89- 104 (27.86/ 9.06) TKAPLGGALGPGVGVE
123- 138 (30.64/ 8.54) TPGPILPLRGPGLGAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 81.62| 25| 42| 211| 235| 3
---------------------------------------------------------------------------
211- 235 (41.04/25.60) LLHSAGLAIQALTNAKPDSSSVAPD
255- 279 (40.58/25.24) LLSSADVNLRRQIYSLEESSLVGPE
---------------------------------------------------------------------------
|