Description | Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MSNLTQEQIKVLEQSRQRLVQLTRSLGSLIASLNQSDPLPPWTSLQSQASIISNNLISVSDQLSDQRDLLSNLVAYPGPEYPGRTQANTLEQLLRTKLDPRVEDWVARGRAAGTEPSNFSDDAHKPLSEAQLAELWEWAPLEANQEARRRNWGGNYTLEEREAGIENVVTGLRRKLEDDESEEESEEEGDGDEMDVVGVARKPGAAELEFKIAPHHTHPVQPFVPLDLILRHMTTGRMP |
Length | 239 |
Position | Head |
Organism | Penicillium patulum (Penicillium griseofulvum) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.692 |
Instability index | 54.67 |
Isoelectric point | 4.74 |
Molecular weight | 26791.43 |
Publications | PubMed=26729047 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP06632 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 48.85| 15| 15| 146| 160| 1 --------------------------------------------------------------------------- 146- 160 (28.40/16.02) EARRRN..WGGNYTLEE 162- 178 (20.46/ 9.93) EAGIENvvTGLRRKLED --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 34.63| 12| 15| 45| 57| 2 --------------------------------------------------------------------------- 45- 57 (14.95/18.44) LQSQASIISnNLI 63- 74 (19.68/16.44) LSDQRDLLS.NLV --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ELEFKIA 2) LDLILRHMTTGRM | 207 226 | 213 238 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab