<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06630

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSVSEQSHAANFISSHTSPNQATVQPPNISSPPSSAPMSTQVSQQPTMSTTNSFPTPASSVSGHPTNATSEDADQGRKSFNTGIQDSAENSGASPTQQPTQHKPTGHDRQTLQTDGTNDFATGQGQYSTEPDAMDIDTQPTSRADTLSLSLDSLQKELTSAFHLCKSSPIVTGPDPSVDLVSLYGLGPIAHSVARMDPVTGEKINRLRKSYEGKLKGLGLAGRNKPLKQEIGAPGSLRYMTLWPEEEWQNQKVHGKAIKVSDMDSALHNLQSRAMQMEPGPIPNNDFWEDILGHEKPVKNPAAGETGKKATPGLAARPSTQSYAASPRSQEAERPRPSRGRKRHYDDNSFAGYGEGFVDDDDDPGFYSNGEGTGKKKRKKDHVAKVSTPMSERSTSYGVGMFGIGAR
Length407
PositionHead
OrganismPenicillium patulum (Penicillium griseofulvum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.05
Grand average of hydropathy-0.883
Instability index46.60
Isoelectric point6.47
Molecular weight43719.57
Publications
PubMed=26729047

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06630
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     158.83|      48|      92|     187|     236|       1
---------------------------------------------------------------------------
  187-  236 (79.78/49.02)	GPIAHSVARMDPVTGEK.INRLRKSYEGKLKGLGLAGRnkPLKQEIGA.PGS
  280-  329 (79.05/43.34)	GPIPNNDFWEDILGHEKpVKNPAAGETGKKATPGLAAR..PSTQSYAAsPRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     142.60|      35|      40|      55|      89|       2
---------------------------------------------------------------------------
   10-   45 (38.59/14.63)	.....AN.FISSHtsPNQATVQPPNisSPPSSAPMST.QVSQQ
   55-   89 (61.25/26.97)	PT..PAS.SVSGH..PTNATSEDAD..QGRKSFNTGI.QDSAE
   95-  130 (42.76/16.90)	PTqqPTQhKPTGH..DRQTLQTD.....GTNDFATGQgQYSTE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.83|      11|      14|     346|     356|       3
---------------------------------------------------------------------------
  346-  356 (22.39/14.50)	DDNSFAGYGEG
  362-  372 (23.44/15.55)	DDPGFYSNGEG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06630 with Med19 domain of Kingdom Fungi
Unable to open file!