<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06629

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMFVRSPVKENELLDLLLEARASSSVTWDPLLPLYVDGLCKVGRVKSSSALASLLKHSSVLDAPGSGEGDVEAQGSPSKAKKQKPSTLMTDIKVIQDVMVFISTGSIPKTVVEAADIYSATVDWIMAVVAWHNHSLDVSQQTGGLMGSPDAVSLFESLGILLAALSGTSKGLEVLSSDYNQASVNEIPIELKTKLGQALSSYLPLCIDVSLPLRHRLEELQKVFNLYPGQSSKALDGPAIDGVNVNALQFESSVMDGPVVNTRAGLYVYINSMVVGRPLVDDTILINYLTNRYQGHNDVLIEEIITAAFDVLSNGVYRNESNRTMLLFRSFLVNKLPAFFAAISAASMVPISMEMCISHALSRLDPNAFPSFSQMFSMQGSSVLSDARQEFLFACASHKLIRESSIEQLLGENPMQTLPGGGPYVKDDLVSQINNNHERAEQLIGEIESMEGNAGAIVGAVVDVMHNLCHQKETMTLKNICNSLSRRPQTLDVMLLFRTTKQVLQPLCAVLDSWKWDEDQGENQPVYDEFGSILLLVLAFKYRYDLSPSDMGISNNDSFLLKLLDRGACSQKLTDLSEKQNKDLSAWIGALFIAEGISEETMSSCSPHEFYMLVTTLFDQSLGACESGKLDFDTLKGGFEYLLEPFLLPSLVVALTWLGNHIWESENDPTIPIKTLHSLVKPSSISGEAQAIHQTVLNITGCPLEEQLKNVRTRNQSRTDIKPILDALEPYLSFRRVGSCHRSELDTWTSHSAGGLIASIRTTIQALVLWSASPGISMAPHAYTHRQVLAGIRILGATRVLGAIIDEVRQQTEAGSGHIALDIATTMVCAPMTESFAVDQNNYHPVDTSKEALPRCTILTLRDALSLQHENVPKIFESDPLRAEVVVRLARRVNMLMAPPSQVSNIDVSNIIQNMHLGVEGQEDRMDLEPSAPDVSRNTANEDDPDNINQMLDKAAADAAAGMDGGIGVGQDMGLDSGAGMDAIDDVLNAADMAVGNPEFLDLDMEGMF
Length1008
PositionTail
OrganismPenicillium patulum (Penicillium griseofulvum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.06
Grand average of hydropathy-0.025
Instability index45.19
Isoelectric point4.78
Molecular weight109815.90
Publications
PubMed=26729047

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06629
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     375.75|     126|     615|      28|     174|       2
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   28-  174 (189.90/179.65)	DP.LLPLYVDGLCKVG.RVKSSS........ALASLLKHSS...........VLDAPGSgegDVEAQGSPSKAKKQKPSTLMTDIKVIQDVMVFISTGSIPKTVVEAadiysatvdwimavvaWHNHSldVSQQTGGLMGSPDAVSLF.ESLGILLAALSGTSK....GLEVL
  643-  794 (185.85/131.50)	EPfLLPSLVVALTWLGnHIWESEndptipikTLHSLVKPSSisgeaqaihqtVLNITGC...PLEEQLKNVRTRNQSRTDIKPILDALEPYLSFRRVGSCHRSELDT................WTSHS..AGGLIASIRTTIQALVLWsASPGISMAPHAYTHRqvlaGIRIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.03|      27|      31|     406|     436|       3
---------------------------------------------------------------------------
  406-  434 (42.70/38.11)	EQLLGEnpMQTLPGGGPYVKDDLVSQINN
  440-  466 (45.33/25.13)	EQLIGE..IESMEGNAGAIVGAVVDVMHN
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.17|      33|     614|     226|     259|       6
---------------------------------------------------------------------------
  226-  259 (54.57/43.76)	YPGQSSK.AL.........DGPAIDGVNVNALqFESSVMDGPVV
  843-  885 (45.60/30.80)	HPVDTSKeALprctiltlrDALSLQHENVPKI.FESDPLRAEVV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06629 with Med5 domain of Kingdom Fungi
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