<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06628

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMASQDASMEEILWRSPPHVQMMGGFLHSNNILFYFAESPFFDSTSNNASLAIQANYNDAFRHFVETREAFEARLKTMQGLEFIVSYDPLQAAAQTDNRFAHEPSNIWVIRKQNRRKRSGMDDEVTVISTYFIVGDCIYMAPSVAGVVGNRILSAVTSLTQLMKSAATLPTFTASHGHTYLPPGVRSKETAGTTSQASQSKEATPMPDVSFPTTESSQSAGKSSLGSSATGSSFQDTRSLAESFSLLTRYGDEFMDESPLVGEPGSFILSRTGGEATGTAAKAVPKIAATAAATGTPSALPVRASTPQVRVETPGKASDKSSSPPSSAGDKSKRKKSRIVS
Length340
PositionHead
OrganismPenicillium patulum (Penicillium griseofulvum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.08
Grand average of hydropathy-0.339
Instability index54.92
Isoelectric point7.84
Molecular weight36360.21
Publications
PubMed=26729047

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. 
ECO:0000256	PIRNR:PIRNR013286
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP06628
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     197.47|      66|     182|      33|     100|       1
---------------------------------------------------------------------------
   33-  100 (106.90/79.94)	FYFAESPFFDSTSNNASLAIQANYNDAfRHFVE.....TR..EAF..EARLKTMQGlEFIVSYDPLQA...AAQTDNRFA
  210-  287 (90.57/58.70)	FPTTESSQSAGKSSLGSSATGSSFQDT.RSLAEsfsllTRygDEFmdESPLVGEPG.SFILSRTGGEAtgtAAKAVPKIA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.19|      17|     122|     182|     199|       2
---------------------------------------------------------------------------
  182-  199 (26.21/20.93)	PGVRSkETAGTTSQASQS
  306-  322 (30.98/19.86)	PQVRV.ETPGKASDKSSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06628 with Med6 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DEFMDESPLVGEPGSFILSRTGGEATGTAAKAVPKIAATAAATGTPSALPVRASTPQVRVETPGKASDKSSSPPSSAGDKSKRKKSRIVS
2) HTYLPPGVRSKETAGTTSQASQSKEATPMPDVSFPTTESSQSAGKSSLGSSATGSSF
251
177
340
233










Molecular Recognition Features






MoRF SequenceStartStop




1) AKAVPKIAATAAATGTPSALPVRAST
2) FSLLTRYG
3) KSSSPPSSAGDKSKRKKSRIV
280
243
319
305
250
339