<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06626

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMTDSFTLPLRPILEQRDCPDTLPVEIAQINNQWGSFREVNEDVLRNKIAEEQDKDGLDEVDESDQDTTDLDSTERLEQLYKRRAEITQFAMQAHMETMFALDFVSLLLSKQAPRQAETSMSAFLKQVAPLGSLNAEVVNPPPKPESTSKDISTVSRGWRIQNFNAAANKLLQAASRLETEVASETRYWNEVLAVKDKGWKISRLPRERQALGVQYGFLEATPVFRDRGLASLRRAEDGALLLDEGLVPSKARYVRVRVIQDGRLSGSSKPTRSAFDGDGTIEDRILQARDTVYEDELFHELVREARAIASFGVTTRQNLIQIPASDNLEILLDLVDTDENALQPQQDISQQGSCLAEGLAHTIRILLAYAHRQNLRRRTLLPLPLTPKTRSIPEHQLIRPALAYIKHMSDVRWLQSLLNDLFGVLQSANLNPPAYTAKIFSTGRLTSPAPTVETIVGQFLTPLLSTFNGKILTPRGSFSISIHTNLSSPPFGTIFDVSFNMPKYPDLGSPGKLSHREEVEAAITHLLLLDVVFTISSKNGSPKSESDKDQAKCTWEAIYPQHGELLLSPSKSEKRKKMKIDLSRQVLSLEIYTVRCIDGTGRGKCEHPSYHSAPRTWKSSPIAGLPNQPSLMDFVSTVVSHA
Length642
PositionHead
OrganismPenicillium patulum (Penicillium griseofulvum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.06
Grand average of hydropathy-0.380
Instability index48.25
Isoelectric point6.17
Molecular weight71697.52
Publications
PubMed=26729047

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06626
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.35|      30|     110|     417|     484|       1
---------------------------------------------------------------------------
  108-  140 (40.61/ 8.34)	LSKQAPrQAETSMSAFLKQVapLGSLNAEVVNP
  445-  474 (51.75/15.95)	LTSPAP.TVETIVGQFLTPL..LSTFNGKILTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.40|      19|      34|     363|     381|       2
---------------------------------------------------------------------------
  363-  381 (33.19/19.31)	IRILLAY.AHRQNLRR.RTLL
  398-  418 (27.21/14.71)	IRPALAYiKHMSDVRWlQSLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.63|      21|      27|     195|     217|       4
---------------------------------------------------------------------------
  195-  217 (32.89/26.88)	KDKGwkISRLPR.ERQALGVQYGF
  225-  246 (30.73/17.23)	RDRG..LASLRRaEDGALLLDEGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.24|      16|      19|      25|      41|       9
---------------------------------------------------------------------------
   25-   41 (22.35/18.08)	EIAQINNQwGSFREVNE
   47-   62 (25.89/14.42)	KIAEEQDK.DGLDEVDE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06626 with Med17 domain of Kingdom Fungi
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