<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06624

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGANTNIHLIDGFSNIYWRIYTEEAGIANNPQEGPANGYTILKHLSRLKDLEARLRLLNCLASCPRRLGLWVFSPTPEFESLQPLYVRGSDAESNKILVGTTTLKVSALGSVSSVDLVKGLSSDNQSQHSTQPAGQPRSNQSQPSSRRQDGYSSSAAIYASFISAVTGSIGLQLIRRHAALPLGSRTLFTAVEKSGYDSPHIDNDSVLSSSCLTTLNIQLTMSGTITVSTQTISQTGITRLCSPHENISEIIDVRPGIDLWLCPNGTIARLVTANIDSPTVPPLGYPTSSNLSAKRIQWKLDVVQWLRNFGMHVGAIDEEPWVEVEVWEPFFARLAGEAWRQSDDSQSALPLKCMLWPARFCFKRASSSNFSSGAQGSLLDEPLDFAEQWSSMTSSLKLDHISNTAQNTPITQDPRPKDQEMSSPPKVETLESIESLSRIAQYPDLQSMNLVYPTPPDGAAAVGLNNPNPSDPFAEDSDFGQPHTIQRSSRRNAPGSDISPVQNTGLGVGTGRYDASDEEDLFGEMNERDFGSKGITDADFSFFDDPDFDGMDGDSRVEDADGTLGASHPRSESEAEAMVDEEPSPNQPREVPTHVETHEVQASPIHHEAPHLSEGPMAPEEQTHTPIDRAGQTISPPLSPVEVKKILFPGPDGEEHQQSTDNRGQGHYHPVAFKKKLSDWDQKYGATGKFWFSGGGSLDTLDQTSAIPIIGIPHRDRSSANAPGSSKERNRASLSLIQSENGLRSASVSSDSSDDSIEIMSEHVPTPAAIPLMPSLKRKRAPSESDIVSVASQEKSVVGTEASSAYAAENSTFLGNFLANFSDWTLTGYFSAFPPQQLPVLPRREGQLEIAQLLVDQITQSSLKHPLDGQIGLFDLESQSLPLQILDETNLLGETSKLDFKRYTSLQDEFVANQTQQQPSQHPPPPKDTPRSFISKLSAPHVRVRRGKEYLEALPPAISFWETFGLEPAHGPKNISAYCIHPQAASEAADVFLRRFGLLYQSCNFGTHTRGEDSVAFEDGLKPWRSETSSYESMMQVLKRTCEQLGSELSQSPATADNHVVYIINPFTHAAALADICSAFWHLFQQLIAGSERRQTRNATELVLQIIPLEFIMSSETMVIPFQADYLNLALEVYSRCRPNDGNRSPLLCAPPMLLADALPRAISFRLAPERSSPLQDGRSLHIAYSKSLDQRWISVAWTDLPGSIQRTMSYCLRYRHSGGSRPISEVRNEIWATTKHIMEKFQARWKVHLATTEPMETDEIEAWASLADHHNKSKPGSLELTILAVNTVPDLILEPPVPPISMAMLNILSSSTPVSTPNPSASVASPEQSGNAATPTSAGPVAYSAPTPTDTSLETDSEAILTDICDDSWLAILSHRLNSSPHLTEFRPALSSGYLLRRKGATDGDGVFSISVNLIYSPRPPASHDIVLKDTLSMYRDIGCLARAKGICSVQNNTLPWHVATALRAQELLSYVF
Length1479
PositionKinase
OrganismPenicillium patulum (Penicillium griseofulvum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.389
Instability index59.78
Isoelectric point5.19
Molecular weight161911.10
Publications
PubMed=26729047

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06624
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.05|      48|      82|     967|    1015|       1
---------------------------------------------------------------------------
  967- 1015 (84.29/68.34)	ETFGLEPAHGP...KNISAYCIHP.QAASEAADVfLRRFGLLYQSCNFGTHTR
 1048- 1099 (76.76/56.17)	EQLGSELSQSPataDNHVVYIINPfTHAAALADI.CSAFWHLFQQLIAGSERR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.64|      45|      81|     469|     515|       2
---------------------------------------------------------------------------
  469-  515 (80.79/40.28)	LNNPN....PSDPFAEDSD..FGQPHtiQRSSRRNAPGSDISPVQNTGLGVGT
  548-  598 (68.86/29.80)	FDDPDfdgmDGDSRVEDADgtLGASH..PRSESEAEAMVDEEPSPNQPREVPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     532.88|     135|     314|     325|     467|       5
---------------------------------------------------------------------------
  325-  460 (233.14/115.55)	PWVEVEVWEPFFARLAGEAWRQSDDSQS.......ALPLKCML.....WPARFCFKRASSSNFS..SGAQGSLLDEPLDFAEQWSSMTSSLK..LD.........................................HISNTAQNTPITQDPRPKDQEMS.....SPPKVETLESiESLSRIAQYPDLQSMNLVYPTP
  642-  772 (194.19/91.73)	PLSPVEVKKILFPGPDGEEHQQSTDNRGqghyhpvAFKKKLSD.....WDQKY...GATGKFWF..SGG.GSL..DTLD...Q.TSAIPIIG..IP.........................................HRDRSSANAPGSSKERNR.ASLS.....LIQSENGLRS.ASVSSDSSDDSIEIMSEHVPTP
  791-  947 (105.54/42.54)	DIVSVASQE...KSVVGTEASSAYAAEN.......STFLGNFLanfsdWTLTGYFSAFPPQQLPvlPRREGQLEIAQL.LVDQITQ..SSLKhpLDgqiglfdlesqslplqildetnllgetskldfkrytslqdeFVANQTQQQPSQHPPPPKDTPRSfisklSAPHV............................
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06624 with Med13 domain of Kingdom Fungi
Unable to open file!