<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06623
Description |
Mediator of RNA polymerase II transcription subunit 20 |
Sequence | MPITGVYFIPSNPNAATALQLVTERLRAAFPNEELTPIGRWGLEQKLLRDTPGLLPSSNSNKKPPNPRYMQFLSLTHYPTHGFIYTSEPEKPVPAPNQTQNQNAAGTPGPVNAIAPDHSPSPPMVMTTVPPSSYGTLFQHFTYACQPFWAHRLTLAVPNGIVYEVGDFRVRLGDVRQTFPTARMRGTVIEIEWRGPSVVETIPVDREDGSFGAGVGGDADVEAAGIDFASSAIEESDIDAEYAATASLIREFWGRLGVEAREAILIPNVGMEVKERLRRWKKAGSGVDARADTSVDGAGSMVSERTEEDPDPWSGADVARQFMEVLRFNR |
Length | 330 |
Position | Head |
Organism | Penicillium patulum (Penicillium griseofulvum) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.366 |
Instability index | 43.11 |
Isoelectric point | 5.12 |
Molecular weight | 36122.16 |
Publications | PubMed=26729047
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364152
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP06623
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 80.03| 24| 28| 253| 276| 1
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253- 276 (42.68/24.25) WGRL..GVEAREAILIPNVGMEVKER
280- 305 (37.34/20.50) WKKAgsGVDARADTSVDGAGSMVSER
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 71.68| 19| 28| 53| 79| 2
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53- 71 (36.02/32.59) GLLPSSNSNKKPPNPRYMQ
82- 100 (35.66/14.54) GFIYTSEPEKPVPAPNQTQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 51.11| 15| 28| 146| 165| 3
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146- 165 (23.80/24.25) QPFWAHRLtlavpNGIVYEV
177- 191 (27.32/15.30) QTFPTARM.....RGTVIEI
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