<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06621

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMEDGINVDDLFGEPNSLELGLPAASPIKGLAQCLDEMRLLGCCQKIAWSRMGCIASISPDGLRVIVRHLQCRPSDGKWILGEESPLAPVLEAHNGNQLAHLSWNETGSELAVVDCSGRISIYSISIALNSITGLRQASFDSGDDGNQVVGMMWLNSQRYVHAFHQAAKVNGRWAYSPFRRRPVGPFHPANKGALICVTRAGQIKLIYQNPDSKWAELPAELKNTGYSDRLLTHASMSATQAGILLATFDACQKMCIYRVQICWNPPQWEPTQGKQPGQYPIPSFRFIHCKVDMPSNILNVNPGPDHSDQSMPFLNSVYSLTRLEIMPGQFDSPAGSTGNPWILGVLSKPLHAIHDYPDQQGPPSVIVRWHMQSTPQALHPKFDEVASKTSNVQAKGRMELRRLDDVYSDKYIVSIDLVEHGTVLAVSHDDSSITCYDTRTMTVLNGLDDSTTVTCLAQAGFHYPLETSGLHIAFSPNACVAVTLDSDGHMQLRLMEHSFGSAEGIYDENNFSAAIAALTLAFSRGCGVDFNSDDILMVALAQLSPEAQITFIGEVYRALPINCNFTAEQDKLMSHPYIPRCLSLQAGLGFKGRLKRRNLSSAVPWATIQLRHASVLFAYFFQYNKGGQTESHDPDVLRMVLGNAKWTLDFSHFLLNEIFDMADEFEDVFNDPEAFTQKLKNSSSLPLLILLSSMSRAFLRFICRGLRGVHAGFATANPASLLGDSRIYYTEICQTLESSPVRIDVYEKFLAGVDSAVKHAYQGAGFGDAEKPGPEKELLVNARIPPVLTTAVATLLRQTVPALKSEINRMGIYLGDYSWLGFANDRRTALYRKQREVDILKKCPLRPPLPLGNDGRMAPLKKRRCARCCEVSGDTNLPRSLLSFKMIAKLGLLRSCVCGGMWVLETDNGDLGVRSVSANGNGNRVSQA
Length928
PositionTail
OrganismPenicillium patulum (Penicillium griseofulvum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.08
Grand average of hydropathy-0.153
Instability index41.76
Isoelectric point6.68
Molecular weight102260.77
Publications
PubMed=26729047

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06621
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.66|      19|      27|     298|     323|       1
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  298-  319 (31.87/27.96)	LnvnPGP.DHSDQSM..PFLNSVYS
  326-  347 (27.79/ 8.66)	M...PGQfDSPAGSTgnPWILGVLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     263.02|      78|     472|      46|     138|       2
---------------------------------------------------------------------------
   49-  129 (131.73/89.88)	SRMGCIASISPDGLRVIVR....HLQCRPSDGKWilgEESPLAPVLEAHNGNQLAH..LSWNETGSELAVVDCSGRISIYSISIALN
  181-  264 (131.29/62.80)	RPVGPFHPANKGALICVTRagqiKLIYQNPDSKW...AELPAELKNTGYSDRLLTHasMSATQAGILLATFDACQKMCIYRVQICWN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.19|      12|      27|     695|     706|       3
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  695-  706 (22.44/11.89)	SRAFLRFICRGL
  725-  736 (22.75/12.13)	SRIYYTEICQTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.56|      16|      45|     470|     487|       5
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  470-  487 (20.83/18.27)	LHIAFSpNACvAVTLDSD
  518-  533 (30.73/16.06)	LTLAFS.RGC.GVDFNSD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.09|      14|      18|     422|     435|       6
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  422-  435 (24.99/15.98)	TVLAVSHDDSSITC
  442-  455 (25.10/16.08)	TVLNGLDDSTTVTC
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.98|      36|      39|     605|     643|      10
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  605-  643 (56.11/43.71)	WaTIQLRHasVLFAYFFQYNKGGQTESHDPDVLRMVLGN
  646-  681 (63.87/39.30)	W.TLDFSH..FLLNEIFDMADEFEDVFNDPEAFTQKLKN
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06621 with Med16 domain of Kingdom Fungi
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