<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06618

Description "Mediator complex, subunit Med12"
SequenceMIPHSSAGGQPWGHPLRTFNGPGRVDNAQMGQYDNPDRPASLQPIRQPVVVDLTAESHDREPPPKRPRLDVPSGSNTDTGAAVGETRSTPGSAISRPAVSWRGRPVWSFQAVVSELPSNENRGDGAAGSKPPSPPPLPAQPWKNNFVAEPEGSGVVKSRESSPVGAVQTTPYRIEIPSVAPLYKGQKPADFAPWTGNHQEDVLSEQTAKQGYYDRTQVSQNESNTARPALYAQLKNRTGLQMLSSVFAAALEKRQTQNTIHAPSTFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKILLDQCLGKWIPVARAVWLAKCVGANEIRAFKRKGTSGALAVGLEAKWVRDWTTNVQQFVEGVFAAPKSSDWKAKMTYAVGLTARLFSENLLDHDHFLEWFLSSFEAASIGTIPIWILMLGIYWNSIMRYRRRGRRLAELLLQKVRQATEAKLTQLQPLIDRLSRFIKKLVLDHTSSMILPNSWEMYKHQVSSALDLGNEAEKALFQSLAERNARVQRPKHSKQTTHRSPHQGIVRLLDSIRSSQDLSSIFGYLDAFDDKAILVFKLLEWLSTPFRHGLCRVYIGVRLLRKWKLAGVDIDSHILAFLSRGQNNQKLNMDQIYHVVSELVRSQTFSVGRYLQWLMARGVTNGSSSAEGGKMKDLPIDIGLIAQLPVARLPEHVGNLRSTLLARTGLSASEENAAIDSVKDVISQRLPGIFGVNESASMALDSLPSNLPWAVKAEVGQWLRRAIAEHNRSAESTNRAALPVGIASVVSALTPAEFYIVRDALESFGDISMLADVLKFASTCGDSTVLASVADTTNCHFDSLCVIGATTDLFRRLIDAYAGIKRLGMPNLDLIFSLIELGLRIPSELNTVSILRQDLSRMENKSIVAASSPVSDHIPEGFGGVDPFFREKLDQLLQSGNVMDEPTLDAVFNTLIKHLESDNGHANLSANDTCRYLAQLRSFHPKHFDGILARWVCSHLRSPERTILLRILPPLIGVGCVTIRAFLALAKRLTISTPATVPNAAQLPADLVQLLVSGDEDSKSFDLVSYRFQLAQQEFLNKNSEEALKIVCDAASSKTDDSSIGHSKLEHSIVMLLRDLLVRHPECAAQNGIQKLIDQYPASLSIVQKALDLLLGVESQYNGHSVLSKVEKLACMTDDFSLPFCQLKLQVLFHADSGSEDRTNIVDAMFKTAVSDCRAHRLHWVELVALMSPDAVRQIRERAEKEFFSIPLLEEPIGEIPGSPDKLGSLETAKMYLTIIEELASSIPDSGAPSVAPVLVEKMDSLLHKIITMHSSAPAKGMTNTSRANFERALAFWFSALLRMIVLHRSAFAQPPAALKTNPLHEQLRLLTSIFCIALSRLPGDVLRLFPAADYFPHPAPAEGFRPCPGILLQTHALDVAASLIDVFPEEVRQQCARFLKEKCPSFVPFMNDSRFLYLLGPMIDQYSANAQQVSAPSPAASGSTPTQSPALFSIVGSSTAQQSVPAASGLSTGLPDSNCMANRLRLQHRGRVVGPYPVRPWELLEDAAPFLGVNDTAVNLGFFDARRVRA
Length1563
PositionKinase
OrganismPenicillium patulum (Penicillium griseofulvum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.153
Instability index47.18
Isoelectric point8.77
Molecular weight172069.04
Publications
PubMed=26729047

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP06618
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.87|      16|      36|    1297|    1312|       1
---------------------------------------------------------------------------
 1297- 1312 (28.43/20.58)	SLLHKIITMHSSAPAK
 1331- 1346 (27.44/19.57)	SALLRMIVLHRSAFAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.92|      21|      37|     348|     368|       2
---------------------------------------------------------------------------
  348-  368 (38.13/29.69)	AVGLEAKWVRDWTTNVQQFVE
  386-  406 (35.79/27.32)	AVGLTARLFSENLLDHDHFLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.19|      25|      37|    1125|    1151|       3
---------------------------------------------------------------------------
 1125- 1151 (35.25/24.30)	IQKL...IDQYpaSLSIVQKALDLLLGVES
 1162- 1189 (38.94/20.61)	VEKLacmTDDF..SLPFCQLKLQVLFHADS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.19|      19|      36|     684|     718|       4
---------------------------------------------------------------------------
  684-  702 (32.54/39.78)	RLPEHVGNLRSTLLARTGL
  721-  739 (32.65/10.07)	RLPGIFGVNESASMALDSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     127.80|      36|      38|      84|     120|       5
---------------------------------------------------------------------------
   70-  106 (38.74/18.36)	.......D...VPSGSntdtgaavGETRSTPGSAISRPAVS..WRG.RPV
  108-  144 (49.34/28.77)	SFQAVVSE...LPSNE....nrgdGAAGSKPPSPPPLPAQP..WKN....
  145-  189 (39.73/16.29)	NFVAEPEGsgvVKSRE....sspvGAVQTTP.YRIEIPSVAplYKGqKPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.30|      42|     279|     293|     342|       6
---------------------------------------------------------------------------
  293-  342 (65.90/58.49)	LRRLSRTIPHGIrGKILLD.QCLGKWipvaravWLAKCVGANEIRAFKRKG
  575-  617 (72.40/44.89)	LEWLSTPFRHGL.CRVYIGvRLLRKW.......KLAGVDIDSHILAFLSRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.92|      24|     279|     212|     237|       7
---------------------------------------------------------------------------
  212-  237 (37.50/31.19)	YydRTQVSQ..NESNTARPALYAQLKNR
  494-  519 (36.42/22.54)	Y..KHQVSSalDLGNEAEKALFQSLAER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     213.70|      58|     204|     777|     834|      11
---------------------------------------------------------------------------
  777-  834 (98.77/72.67)	GIASVVSALTPAEF.........YIVRDALESFGDISMLADVLKFASTCGDSTVLASVADTTNCHFD
 1009- 1058 (77.56/55.18)	GVGCV....TIRAF.........L....ALAKRLTISTPATVPNAAQLPADLVQLLVSGDEDSKSFD
 1061- 1105 (37.37/22.04)	...SYRFQLAQQEFlnknseealKIVCDAASSKTD..........DSSIGHSKLEHSI.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.94|      22|      29|    1231|    1256|      12
---------------------------------------------------------------------------
 1224- 1254 (21.41/32.07)	SPdavrqIrERAeKEFFSIplLEEPIGEIP..G
 1255- 1283 (28.53/18.47)	SPdklgsL.ETA.KMYLTI..IEELASSIPdsG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.69|      27|      38|    1400|    1426|      14
---------------------------------------------------------------------------
 1400- 1426 (45.25/26.14)	CPG...ILLQTHALDVAASLIDVFPEEVRQ
 1436- 1465 (43.44/24.80)	CPSfvpFMNDSRFLYLLGPMIDQYSANAQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.93|      27|     103|     633|     663|      17
---------------------------------------------------------------------------
  633-  663 (38.47/33.06)	SELVRSQTFSVGrylQWLMaRGVTNGSSSAE
  741-  767 (49.46/28.65)	SNLPWAVKAEVG...QWLR.RAIAEHNRSAE
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06618 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GQKPADFAPWTGNHQEDVLSEQTAKQGYYDRTQVSQNESNTARPALY
2) MIPHSSAGGQPWGHPLRTFNGPGRVDNAQMGQYDNPDRPASLQPIRQPVVVDLTAESHDREPPPKRPRLDVPSGSNTDTGAAVGETRSTPGSAISRPAVS
3) QAVVSELPSNENRGDGAAGSKPPSPPPLPAQPWKNNFVAEPEGSGVVKSRESSPVGAVQTTP
185
1
110
231
100
171










Molecular Recognition Features






MoRF SequenceStartStop




NANANA