<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP06604

Description Uncharacterized protein
SequenceMIPHSSAGGQSWGHPLRTFNGGPGRVDNAQMLGQYDQPDRSASLPQPPIRQPVVVDLTAGGPESQDREPPPKRPRLDVPSASHTSDTGAPVGETRSTPGSAMSRPAVSWRGRPAWSFQAVVSEIPSNENRGDGVAGSKPPSPPPLPAQPWMNNFVAESEGSGVVKSRESSPVGAVQTTPYRIEIPSVAPVYKGQKPADFAPWTGNHPEDVLSEQTAKQGYYDRTQVSQNESNTARPALYAQLKNRTGLQMLSSVFAAALEKRQSHNTIHAPSTFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKILLDQCLGKWIPIARAVWLAKCVGANEIRAFKRKGTSGALAVGLEAKWVRDWTTNVQQFVEGVFAAPKSSDWKAKMTYAVGLTARLFSENLLDHDHFLEWFLSSFEAASIGTIPVWLLMLGVYWNSIMRYRRRGRRLAELLLQKVRQATEAKLTQLQPLIDRLSRFIKKLVLDHTSSMILPNSWETYQQQVSSALDLGNEAEKALFQSLAERNARVQRPRHSKQTTQRSPHQRIVRLLDSIRSAQDLSSIFGYLDAFDDKAVLVFKLLEWLSTPFRHGLCRVYIGVRLLRKWKLAGVDIDSHILAFLSRGQNNQKLNMDQIYHVVSELVRSQTFSVGRYLQWLMARGVTNVSSSDEERKVKDLPIDIGLIAQLPVARLPEHVGNLRSTLLTRAGLSTSEENASIDSVKEIISQRLPGIFGVHESASMALDSLPPDLPWAVKAEVGQWLRRAIAEHNRSAESTNRGAFPVGIASVVSALTPAEFYTVRDALESFGDISMLADVLKFASSCGDGTVLASVADTTNCHFDSLCVIGATTDLFRRLIDAYAGMKRFGMPSLDLIFSLIELGLRIPSDLNTVSILRQDLSRMENKAIMAASSPVSDHIPDGFGGVDPFFREKLDHLLQSGNVMDEPTLDAIFNTLIKHLESDDGHENLSANDTCRYLAQLRSFHPKHFDGILARWVCGHLRSPERTILLRILPPLIGVGCVTIRAFLALAKKLTLSKPATVPNAAQLPADLVQLLVSGGKDSKSFDLVSYRFQLAQQEFLNKNSEEALKIVCDAASSNAGSSSTGHTEMERSIVMLLRDLLVRHPECAAQNGMQKLMDQYPAALSIVQKALDLLLGIESRSDGSSVLSKVEKLACMTDDFSLPFCQLKLQVLFHADSGSEDRTNIVDAMFKTAVSDCRAHRLHWVDLVALMSPDAVRQIRERAEKEFFSIPLLEEPVGDIPDSPDKLGSLETAKMYLTIIEELASSIPDSGAPSVAPVLVEKMDSLLHKIITMHNSTLAKGVSNTDRSKLERALAFWFSALLRIIVLHRSAFSQPPPALKINPLHEQLRLLTSVFCIALSRLPGDILRLFPAADYFPHPTPAEGFRPCPGILLQTHALDVAASLIDIFPDEVRHQCARFLKEKCPSFVPFQNDSRFLYLLGPISDQYPANAHQASAPSPAASGSTPTPTPALFSITGSSTAQQSVTTAPGPSTAPPDSNSMANRLRLQHRGRVVGPYPVRPWELLEDAAPFLGVNDTAVNLGFFDARRVRA
Length1571
PositionKinase
OrganismPenicillium freii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.190
Instability index49.46
Isoelectric point8.69
Molecular weight173005.80
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP06604
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.68|      33|      35|    1283|    1316|       1
---------------------------------------------------------------------------
 1283- 1316 (49.95/35.00)	LASSIPDSGAPSVAPVLVEKMDSLLhKIITMHNS
 1318- 1350 (53.72/32.66)	LAKGVSNTDRSKLERALAFWFSALL.RIIVLHRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.92|      21|      35|     356|     376|       2
---------------------------------------------------------------------------
  356-  376 (38.13/24.94)	AVGLEAKWVRDWTTNVQQFVE
  394-  414 (35.79/22.95)	AVGLTARLFSENLLDHDHFLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     299.37|      99|     279|     822|     930|       3
---------------------------------------------------------------------------
  822-  930 (150.96/117.69)	SSCG....DGTVLASVADTTNCHFDslCvigATTDLFRRLIDAYAGMKRFGMPSLDLIFSlIEL...GLRIPSDLNTVSILRQDLS....RMENKAIMAASSPVSDHIpdgfGGVDPFFR
 1102- 1211 (148.41/90.14)	SSTGhtemERSIVMLLRDLLVRHPE..C...AAQNGMQKLMDQYPAALSIVQKALDLLLG.IESrsdGSSVLSKVEKLACMTDDFSlpfcQLKLQVLFHADSGSEDRT....NIVDAMFK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.75|      19|      38|    1389|    1409|       4
---------------------------------------------------------------------------
 1389- 1409 (35.87/22.18)	LFPaaDYFPHPTPAEGFRPCP
 1427- 1445 (33.88/15.61)	IFP..DEVRHQCARFLKEKCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.43|      13|      15|     309|     323|       6
---------------------------------------------------------------------------
  309-  323 (19.53/21.26)	PhgIRGKILLDQCLG
  327-  339 (24.90/17.01)	P..IARAVWLAKCVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.12|      20|      30|      15|      40|      10
---------------------------------------------------------------------------
   15-   40 (28.60/30.01)	PLRTfnggPGRVDnaQMLGQYDQPDR
   48-   67 (36.52/19.33)	PIRQ....PVVVD..LTAGGPESQDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.31|      37|     104|     656|     693|      11
---------------------------------------------------------------------------
  656-  693 (57.80/41.39)	QWLMaRGVTNVSSSDEERKVKDLPIDI.GLIAQLPVARL
  761-  798 (58.51/37.39)	QWLR.RAIAEHNRSAESTNRGAFPVGIaSVVSALTPAEF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.52|      14|    1211|     263|     277|      14
---------------------------------------------------------------------------
  263-  277 (24.53/20.94)	QSHNTIHAPSTfKPP
 1503- 1516 (27.98/17.76)	QSVTTAPGPST.APP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.75|      38|      80|      85|     134|      15
---------------------------------------------------------------------------
   85-  123 (67.64/72.98)	SDTGAPVGETRSTPGSaMSRPAVS..WRG.RPA....WS...FQAVVSE
  166-  213 (50.12/26.61)	SRESSPVGAVQTTPYR.IEIPSVApvYKGqKPAdfapWTgnhPEDVLSE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP06604 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FQAVVSEIPSNENRGDGVAGSKPPSPPPLPAQPWMNNFVAESEGSGVVKSRESSPVGAVQTTP
2) GQKPADFAPWTGNHPEDVLSEQTAKQGYYDRTQVSQNESNTARPALY
3) MIPHSSAGGQSWGHPLRTFNGGPGRVDNAQMLGQYDQPDRSASLPQPPIRQPVVVDLTAGGPESQDREPPPKRPRLDVPSASHTSDTGAPVGETRSTPGSAMSRPAVSW
4) NAHQASAPSPAASGSTPTPTPALFSITGSSTAQQSVTTAPGPSTAPPDSNSMANRLRL
117
193
1
1470
179
239
109
1527










Molecular Recognition Features






MoRF SequenceStartStop




NANANA