Description | Mediator of RNA polymerase II transcription subunit 31 |
Sequence | MQSAEKSSENATLDQEELPSRFEVELEFVQALANIPYVTHLLTQHQLWQDPKFKEYLKYLEYWCESPYVQYIVYPNSLFVLKLLNGFLEKAETNEDGILEGAEELPKILQMHGGQLMNDMVERWKA |
Length | 126 |
Position | Middle |
Organism | Eremothecium sinecaudum |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Eremothecium. |
Aromaticity | 0.12 |
Grand average of hydropathy | -0.431 |
Instability index | 46.18 |
Isoelectric point | 4.59 |
Molecular weight | 14800.64 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364129 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription, DNA-templated GO:0006355 IEA:InterPro |
Binary Interactions |
Repeats | >MDP06597 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 88.76| 26| 28| 13| 40| 1 --------------------------------------------------------------------------- 13- 38 (43.77/33.09) LDQEEL..PSRFEVELEFVQALANIPYV 42- 69 (45.00/26.69) LTQHQLwqDPKFKEYLKYLEYWCESPYV --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) EELPSR 2) ILEGAEELPKIL 3) VERWKA | 16 98 121 | 21 109 126 |
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